Moving from the bench towards a large scale, industrial platform process for adeno‐associated viral vector purification

Viral contamination in biologic manufacture and implications for emerging therapies

(2020) Paul W. Barone et al.   NATURE BIOTECHNOLOGY

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Scalable method utilizing low pH for DNA removal in the harvest of recombinant adeno-associated virus vectors

(2019) Caryn L. Heldt   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Production of adeno-associated virus vectors for in vitro and in vivo applications

(2019) Toyokazu Kimura et al.   Scientific Reports

Contributions of depth filter components to protein adsorption in bioprocessing

(2018) Ohnmar Khanal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process

(2018) Hoang C. Nguyen et al.   Biotechnology Journal

Exploring a New Enzymatic Tool for AAV Production

(2018) Andrew Ward   Genetic Engineering & Biotechnology News

Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process

(2018) Hoang C. Nguyen et al.   Biotechnology Journal

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

(2018) Shelley A. Nass et al.   Molecular Therapy-Methods & Clinical Development

Helper-free Production of Laboratory Grade AAV and Purification by Iodixanol Density Gradient Centrifugation

(2018) Sean M. Crosson et al.   Molecular Therapy-Methods & Clinical Development

Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9

(2018) Taro Tomono et al.   Molecular Therapy-Methods & Clinical Development

Application of quality by design in the current drug development

(2017) Lan Zhang et al.   Asian Journal of Pharmaceutical Sciences

Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry

(2016) Elizabeth E. Pierson et al.   ANALYTICAL CHEMISTRY

The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry

(2016) Glen R. Bolton et al.   BIOTECHNOLOGY PROGRESS

Advance chromatin extraction improves capture performance of protein A affinity chromatography

(2016) Rui Nian et al.   JOURNAL OF CHROMATOGRAPHY A

Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector

(2016) Bryan A Piras et al.   Molecular Therapy-Methods & Clinical Development

Manufacturing of recombinant adeno-associated viral vectors for clinical trials

(2016) Nathalie Clément et al.   Molecular Therapy-Methods & Clinical Development

A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform

(2016) Laura Adamson-Small et al.   Molecular Therapy-Methods & Clinical Development

Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties

(2015) Weihong Qu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

(2015) Brenda Burnham et al.   Human Gene Therapy Methods

Stability and Compatibility of Recombinant Adeno-Associated Virus Under Conditions Commonly Encountered in Human Gene Therapy Trials

(2015) Alisha M. Gruntman et al.   Human Gene Therapy Methods

Simple downstream process based on detergent treatment improves yield and in vivo transduction efficacy of adeno-associated virus vectors

(2015) Gabriella Dias Florencio et al.   Molecular Therapy-Methods & Clinical Development

Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin

(2015) Qiang Wang et al.   Molecular Therapy-Methods & Clinical Development

Biosafety of Recombinant Adeno-associated Virus Vectors

(2014) David Dismuke et al.   CURRENT GENE THERAPY

Herpes Simplex Virus Clearance During Purification of a Recombinant Adeno-Associated Virus Serotype 1 Vector

(2014) Guo-jie Ye et al.   Human Gene Therapy Clinical Development

A simplified purification protocol for recombinant adeno-associated virus vectors

(2014) Mark Potter et al.   Molecular Therapy-Methods & Clinical Development

Viral clearance by flow-through mode ion exchange columns and membrane adsorbers

(2013) G. R. Miesegaes et al.   BIOTECHNOLOGY PROGRESS

Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics

(2013) V. Rayaprolu et al.   JOURNAL OF VIROLOGY

Matching cellular dimensions with molecular sizes

(2013) Michael Reth   NATURE IMMUNOLOGY

Rapid and simplified purification of recombinant adeno-associated virus

(2012) Ping Guo et al.   JOURNAL OF VIROLOGICAL METHODS

Analysis of Particle Content of Recombinant Adeno-Associated Virus Serotype 8 Vectors by Ion-Exchange Chromatography

(2012) Martin Lock et al.   Human Gene Therapy Methods

Identification of the heparin binding site on adeno-associated virus serotype 3B (AAV-3B)

(2011) Thomas F. Lerch et al.   VIROLOGY

Efficient Serotype-Dependent Release of Functional Vector into the Culture Medium During Adeno-Associated Virus Manufacturing

(2010) Luk H. Vandenberghe et al.   HUMAN GENE THERAPY

Scalable Purification of Adeno-associated Virus Serotype 1 (AAV1) and AAV8 Vectors, Using Dual Ion-Exchange Adsorptive Membranes

(2009) Takashi Okada et al.   HUMAN GENE THERAPY

A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

(2009) Richard H Smith et al.   MOLECULAR THERAPY

Roadmap for implementation of quality by design (QbD) for biotechnology products

(2009) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY

Manufacturing and characterizing AAV-based vectors for use in clinical studies

(2008) J F Wright   GENE THERAPY

Characterizing clearance of helper adenovirus by a clinical rAAV1 manufacturing process

(2007) Barbara A. Thorne et al.   BIOLOGICALS