Article
Biochemistry & Molecular Biology
Jon Ashley, Anna-Lisa Schaap-Johansen, Mohsen Mohammadniaei, Maryam Naseri, Paolo Marcatili, Marta Prado, Yi Sun
Summary: The TdT enzyme plays a crucial role in V(D)J recombination in lymphocytes, allowing for diverse expression of immunoglobulins and T-cell receptors. A new screening method was demonstrated using TdT to form vsDNA libraries for binding to protein targets, offering the possibility of rational aptamer design and controlled reaction conditions for improved screening outcomes. This approach allows for screening based on both size and sequence in a single round, reducing PCR bias and resulting in high affinity and selective aptamers.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Applied
Yangyang Zhou, Huiyuan Wang, Zhihui Zhao, Donglei Luan, Xiaojun Bian, Keqiang Lai, Juan Yan
Summary: We developed a colloidal SERS method using petal-like plasmonic nanoparticle (PLNP) clusters for the detection of enrofloxacin (EnFX). PLNPs were synthesized using single-stranded DNA composed of homo-cytosine deoxynucleotides (hC) catalyzed by terminal deoxynucleotidyl transferase. SERS hot spots were created by agglomeration of PLNPs using potassium iodide solution, allowing attachment of EnFX molecules to the negatively charged PLNPs surface via electrostatic interactions. This method enabled direct in situ detection of antibiotic residues with a limit of detection (LOD) of 1.15 µg/kg for EnFX. The spiked recoveries of the SERS method ranged from approximately 92.7% to 107.2% with RSDs ranging from 1.05% to 7.8%, indicating its applicability for actual sample detection. This colloidal SERS measurement platform shows great promise in various applications, especially for real-time and on-site food safety screening due to its rapidness, simplicity, and sensitivity.
Article
Biophysics
Lei Huang, Shulin Tian, Wenhao Zhao, Ke Liu, Xing Ma, Jinhong Guo
Summary: The lateral flow assay (LFA) is a widely used paper-based on-site biosensor for detecting target analytes in minutes. Aptamers, as biorecognition molecules, are being explored as an alternative to antibodies in LFAs, offering advantages over traditional methods. Different formats of aptamer-based LFAs can achieve on-site detection of target analytes efficiently.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Peng Yi, Dan Luo, Zhong Gao, Qinhua Chen, Yajuan Zhou
Summary: A fluorescence aptasensor based on the combination of magnetic nanoparticles (MNPs), terminal deoxynucleotidyl transferase (TdT), and CRISPR/Cas12a was developed for the determination of nasopharyngeal carcinoma (NPC)-derived exosomes. The MNPs eliminated background interference, TdT provided signal amplification, and CRISPR/Cas12a triggered the cleavage of bi-labeled DNA reporter. The aptasensor exhibited excellent sensitivity and specificity for NPC-derived exosome determination.
Article
Chemistry, Analytical
Yuwei Wang, Linbin Li, Zihe Dong, Yan Yu, Aie Zhou, Xiaofen Zhao, Juan Zhang
Summary: A novel electrochemical biosensor was developed for ultrasensitive detection of HCV core antigen (HCVcAg) using terminal deoxynucleotidyl transferase (TdT) amplification and DNA nanowires (DNW). The biosensor achieved a wide linear range for HCVcAg detection from 0.1 to 312.5 pg/mL with a low limit of detection of 32 fg/mL, demonstrating good practicality for use in clinics.
Article
Environmental Sciences
Liuyin Hu, Jiahua Cui, Yalin Wang, Jinping Jia
Summary: A novel synergistic signal-amplifying electrochemical biosensor was developed for the sensitive and rapid quantification of Bisphenol A (BPA). The biosensor utilized a recognition probe (RP) constructed by BPA aptamer modified gold nanoparticles-loaded magnetic reduced graphene oxide (Aptamer-MrGO@AuNPs), and a signal probe (SP) constructed by BPA aptamer-complementary single-stranded DNA (ssDNA) functionalized methylene blue (MB)-loaded gold nanoparticle (ssDNA-AuNP@MBs). The biosensor achieved a low detection limit of 0.141 pg/mL and successfully detected BPA in real environmental water samples.
Article
Chemistry, Multidisciplinary
Xiaoliang Zhang, Le Wang, Xiaochun Li, Xiujun Li
Summary: A colorimetric aptasensing method using gold nanoparticle (AuNP) aggregation was developed for quantitative detection of sulfadimethoxine (SDM) with a smartphone. The R, G, and B values of smartphone images were analyzed for quantitative analysis of SDM. This method provides a simple, fast, and easy to read approach for on-site quantitative biochemical and cellular analysis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Spectroscopy
Zhimei Li, Ting Pi, Kefang Yang, Ziyi Xia, Yuchuan Feng, Xiangjuan Zheng, Ruihong Deng, Baozhu Chi
Summary: A label-free fluorescence probe based on poly-thymine copper nanoclusters engineered by terminal deoxynucleotidyl transferase is proposed for methyltransferase activity assay. This economical method demonstrates specificity and high efficiency for screening DNA methylation inhibitors, showing great potential for future drug development and clinical cancer diagnosis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Yue Sun, Liu Zang, Jianzhong Lu
Summary: In this study, a sensitive method was developed to simultaneously detect multiple DNA glycosylases. The method is based on the target-initiated removal of damaged base and terminal deoxynucleotidyl transferase (TdT)-assisted labeling and signal amplification. The method has the advantages of high sensitivity, specificity, and multiplex and can be used for DNA glycosylase-related biomedical research.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xinmei Song, Yujie Liu, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: Using a new phosphorothioate-modified DNA hairpin probe, we developed a label-free and highly sensitive electrochemical sensor for detecting abnormal myeloperoxidase (MPO) expression associated with inflammation and neurodegenerative diseases. This sensor combines DNAzyme-assisted cleavage recycling with DNA polymerization reaction to monitor MPO. It exhibits a linear range of 0.1-100 ng mL-1 and achieves a low detection limit of 0.046 ng mL-1 for MPO. The sensor is also highly selective against interferents and capable of detecting MPO in diluted human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Pharmacology & Pharmacy
Weicong Ye, Longjie Li, Zishan Feng, Bocheng Tu, Zhe Hu, Xianjin Xiao, Tongbo Wu
Summary: A highly sensitive and selective method based on TdT and Endo IV was developed to quantify ALP activity. This method can detect the presence of ALP by detecting the elongation of a poly A tail, and has potential applications.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Fisheries
Jiaxin Liu, Xinyue Zhang, Jiaying Zheng, Yepin Yu, Xiaohong Huang, Jingguang Wei, Omar Mukama, Shaowen Wang, Qiwei Qin
Summary: Iridoviruses are known to cause serious diseases in fish species worldwide. Singapore grouper iridovirus (SGIV) has caused significant economic losses in grouper aquaculture without effective therapies. A novel LFB combined with DNA aptamers has been developed for rapid and sensitive detection of SGIV infection, showing high specificity and sensitivity in vitro and in vivo.
Article
Electrochemistry
Qi Wang, Tingting Hao, Kaiyue Hu, Lingxia Qin, Xinxin Ren, Zhiyong Guo, Sui Wang, Yufang Hu
Summary: A novel circuit system with autonomous compensation solution ohmic drop is developed to improve the signal generation of traditional electrochemical biosensors. It is successfully applied for the analysis of terminal deoxynucleotide transferase (TdT) and its small molecule inhibitors, as well as mimicking TdT-related signal communication in various logic gates.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Xiaoyun Lu, Jinlong Li, Congyu Li, Qianqian Lou, Kai Peng, Bijun Cai, Ying Liu, Yonghong Yao, Lina Lu, Zhenyang Tian, Hongwu Ma, Wen Wang, Jian Cheng, Xiaoxian Guo, Huifeng Jiang, Yanhe Ma
Summary: By combining evolutionary analysis, mutagenesis scanning, and rational design, we have engineered ZaTdT, an enzyme that shows greatly improved catalytic activity for 3'-ONH2-modified nucleotides, enabling highly efficient enzymatic DNA synthesis.
Review
Biochemistry & Molecular Biology
Jon Ashley, Indiia G. Potts, Femi J. Olorunniji
Summary: The use of polymerase enzymes in biotechnology has provided unprecedented control over DNA manipulation, with terminal deoxynucleotidyl transferase (TdT) being one of the most intriguing enzymes. TdT is capable of template independent stepwise addition of nucleotides onto an oligonucleotide chain. This review comprehensively discusses the unique properties and applications of TdT as a biotechnology tool, and explores its increasing role in various fields.
Article
Biophysics
Fulin Zhu, Xiaojun Bian, Hongcai Zhang, Yanli Wen, Qian Chen, Yongliang Yan, Liang Li, Gang Liu, Juan Yan
Summary: This study investigates the self-assembling of tetrahedral framework nucleic acids in microfluidic devices, creating a three-dimensional reaction space at nanoscale and improving reaction kinetics during molecular recognition. The novel FNA-engineered microfluidic interface enables a one-stop assay of E. coli O157:H7 with high bacterial detection efficiency, selectivity, and precision. The application of the FNA interface shows promising potential for developing microfluidic biosensors for other pathogenic microorganisms or circulating tumor cells by changing the aptamers.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Na An, Kai Li, Yukun Zhang, Tingting Wen, Weixiao Liu, Gang Liu, Liang Li, Wujun Jin
Summary: Researchers have developed a multiplexed, regenerable, and real-time SPR biosensor for detecting GMOs, which has good specificity and sensitivity. The biosensor has a detection limit of 0.1 nM and can be stably regenerated over 100 times with good reproducibility.
Article
Chemistry, Applied
Tingting Zhao, Qian Chen, Yanli Wen, Xiaojun Bian, Qing Tao, Gang Liu, Juan Yan
Summary: We developed a rapid and sensitive colorimetric biosensor based on competitive recognition and signal amplification strategy, which can achieve high selective detection of kanamycin through competitive recognition with kanamycin and signal amplification.
Article
Biophysics
Qian Chen, Run Tian, Gang Liu, Yanli Wen, Xiaojun Bian, Donglei Luan, Huiyuan Wang, Keqiang Lai, Juan Yan
Summary: In this study, a simple, highly sensitive and specific SERS aptasensor was developed for the quantification of kanamycin. The sensor utilized DNA hydrogel network to fish plasmonic core-shell nanoparticles, and integrated competitive binding mode of aptamer, ligation-rolling circle amplification (L-RCA), and gap-containing Au@Au nanoparticles (GCNPs). The novel SERS aptasensor achieved ultrasensitive quantification of kanamycin down to 2.3 fM, with excellent selectivity and precision even for real food samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Green & Sustainable Science & Technology
Qinqin Xue, Ruiyan Guo, Yanli Wen, Lele Wang, Xianguo Cheng, Gang Liu, Qingyu Wu
Summary: This study developed a fluorescence-based Pb2+ biosensor by fusing DNAzymes with tetrahedral DNA nanostructures. The biosensor showed great sensitivity and selectivity in detecting Pb2+ in plant extracts, and has the potential for identifying and tracking polluted regions and facilitating cleaner crop production.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Plant Sciences
Hui Feng, Cong Lin, Wei Liu, Liang Xiao, Xuhong Zhao, Lifang Kang, Xia Liu, Tao Sang, Zili Yi, Juan Yan, Hongmei Huang
Summary: Research has shown that interspecific hybrids of Miscanthus have better adaptability in marginal lands than their parents. The F1 population, a hybrid of Miscanthus sacchariflorus and Miscanthus lutarioriparius, inherited stress response pathways from the female parent, which may explain its higher adaptability and biomass yield compared to the male parent.
Article
Chemistry, Analytical
Yu Zheng, Lele Wang, Li Xu, Yan Li, Xue Yang, Zhenzhou Yang, Lanying Li, Min Ding, Shuzhen Ren, Feiyan Gong, Jinxue Chang, Chengming Cao, Yanli Wen, Liang Li, Gang Liu
Summary: RNA interference (RNAi) technology has great potential in agriculture. Researchers have developed a novel RNA electrochemical biosensor for analyzing RNA molecules in GM maize samples. The biosensor shows high sensitivity and specificity, providing a reliable measurement method for RNAi safety and quality assessment.
Article
Chemistry, Analytical
Liu Ting, Lin Xiao-Hui, Chen Qian, Bian Xiao-Jun, Yan Juan
Summary: In this study, a surface bacterial imprinting film-based impedance sensor was developed for the rapid and sensitive detection of Salmonella Paratyphi B. The sensor showed good analysis performance with fast recognition, wide linear range, and low detection limit. Compared with existing bacterial biosensors, this impedance sensor had advantages of high preparation efficiency, low cost, and environmental friendliness, indicating potential applications in foodborne pathogenic bacteria detection.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhang Qian-Wen, Chen Qian, Bian Xiao-Jun, Yan Juan
Summary: Aptasensor based on aldehyde magnetic beads, enzyme digestion and signal amplification technique was developed for colorimetric detection of S. typhimurium. The sensor showed good response performance, low detection limit and high recovery rate, indicating potential application prospects.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiawei Qi, Pinhua Rao, Lele Wang, Li Xu, Yanli Wen, Wen Liang, Zhenzhou Yang, Xue Yang, Changfeng Zhu, Gang Liu
Summary: Pattern recognition, also known as array sensing, is a recognition strategy based on high-throughput analysis data. In this study, a sensor array was constructed using FAM-labeled DNA probes and 2D nanosheet materials to identify bacterial pathogens and proteins. By utilizing an ordered and extendable DNA library with specific sequences, competitive interactions between DNA and nanosheets were manipulated for precise target recognition. This work provides a valuable and straightforward approach to enhance pattern recognition capabilities.
Article
Chemistry, Analytical
Tao Qing, Chen Qian, Bian Xiao-Jun, Liu Gang, Yan Juan
Summary: Utilizing rolling circle amplification technique, long single-stranded DNA containing multiple copy units was used as scaffold strand to form DNA origami belts with short staple strands. The study revealed that DNA belts exhibited poor resistance to acid and alkali environments, with the best stability in neutral pH and susceptibility to extreme pH conditions.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Li Xu, Jiawei Qi, Yanli Wen, Wen Liang, Lele Wang, Zhenzhou Yang, Xue Yang, Yu Qi, Manlei Duan, Keke Zhao, Jie Gu, Yiji Shen, Pinhua Rao, Min Ding, Shuzhen Ren, Liang Li, Gang Liu
Summary: An electrochemical biosensor for transgene-derived long RNA was developed using a poly-adenine DNA capture probe, with enhanced stability and optimized surface density for hybridization. Multiple reporter probe system and RT-RPA technology improved sensitivity and selectivity for RNAi GMO samples, showing great potential in detection and analysis of functional RNA molecules.
Article
Chemistry, Analytical
Tong Zhang, Qing Tao, Xiao-Jun Bian, Qian Chen, Juan Yan
Summary: The study developed an aptasensor for visualized and rapid detection of E. coli O157:H7, based on aldehyde magnetic beads, rolling circle amplification (RCA) and DNA hydrogel. The sensor showed high specificity and sensitivity, with a detection limit of 4x10(3) CFU/mL and the detection could be completed within 30 minutes. The aptasensor has potential in applications of food safety detection due to its efficient amplification and visualized readout.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Fu-Lin Zhu, Xiao-Jun Bian, Run Tian, Liang Li, Juan Yan, Gang Liu
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)