Article
Fisheries
Min Li, Yidi Kong, Xueqin Wu, Zhuang Yin, Xiaotian Niu, Guiqin Wang
Summary: The study found that dietary alpha-lipoic acid can effectively reduce lead accumulation in Channa argus, reverse Pb-induced alterations in biochemical and immunity parameters, inhibit Pb-induced reduction in antioxidant enzyme activities, and relieve Pb-induced inflammatory response and oxidative stress by regulating NF-kappa B and Nrf2 signaling pathways.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: Alpha-lipoic acid exhibits protective effects against chronic ammonia stress in crucian carp by alleviating oxidative stress and endoplasmic reticulum stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: This study investigated the protective effects of alpha-lipoic acid against chronic ammonia stress in crucian carp. The results showed that alpha-lipoic acid effectively induced humoral immunity, alleviated oxidative stress and endoplasmic reticulum stress, and ultimately reduced liver injury caused by ammonia poisoning.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Ceylanli, Ahmet Ozer Sehirli, Sevgi Gencosman, Kerem Terali, Huseyin Sah, Nurhayat Gulmez, Serkan Sayiner
Summary: This study found that ALA has potential protective benefits against 5-FU-induced gastrointestinal mucositis. ALA can reduce inflammation and oxidative stress caused by mucositis, promote tissue repair, and have significant implications for cancer patients, especially those receiving 5-FU therapy.
Article
Immunology
Yuchao Wang, Yue Zheng, Bingcai Qi, Yanwu Liu, Xuan Cheng, Jianyu Feng, Wenqing Gao, Tong Li
Summary: ALA alleviates MI by inhibiting inflammation, oxidation, apoptosis, and autophagy through the HMGB1/NF-κB pathway, and induces M2b polarization, potentially serving as a potential strategy for MI treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Xiaogang Luo, Dongli Xie, Tong Wu, Wei Xu, Qingyang Meng, Kangli Cao, Jianchen Hu
Summary: Extensive exposure to nanomaterials can cause oxidative stress and inflammation, increasing the risk of adverse health outcomes. Alpha-lipoic acid (ALA) has shown antioxidant and anti-inflammatory activities, suggesting its potential effectiveness in preventing nanomaterial-induced toxicity. A meta-analysis of multiple studies found that ALA supplementation significantly affected oxidative stress, inflammation, apoptosis, DNA damage, and organ damage caused by nanomaterials. In vitro studies also demonstrated that ALA intervention increased cell viability, decreased ROS levels, inhibited cell apoptosis, and chelated metal ions. These findings suggest that ALA supplementation may be a potential strategy for preventing nanomaterial-induced toxicity.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Mateusz Maciejczyk, Ewa Zebrowska, Milosz Nesterowicz, Elzbieta Supruniuk, Barbara Choromanska, Adrian Chabowski, Malgorzata Zendzian-Piotrowska, Anna Zalewska
Summary: The study found that alpha-lipoic acid (ALA) can improve metabolic status in insulin-resistant rats and has positive effects on oxidative balance, sphingolipid metabolism, neuroinflammation, apoptosis, and beta-amyloid accumulation in the hypothalamus and cerebral cortex.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Roshan Lal, Ravinder Naik Dharavath, Kanwaljit Chopra
Summary: This study aimed to investigate the potential neuroprotective and memory-improving effects of alpha-lipoic acid (ALA) against doxorubicin (DOX)-induced cognitive impairment. The results showed that ALA treatment significantly protected against DOX-induced memory impairment and alleviated DOX-induced oxidative and inflammatory damage through upregulation of the NRF-2/HO-1 signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Peng Jiang, Zongzhen Zhai, Linxian Zhao, Kai Zhang, Liwei Duan
Summary: This research found that α-lipoic acid (LA) has a protective effect against ulcerative colitis (UC) by alleviating UC symptoms and reducing the production of pro-inflammatory cytokines. LA treatment can also inhibit intestinal cell apoptosis and oxidative stress. In addition, it regulates the Keap1-Nrf2 signaling pathway and inhibits ferroptosis. LA can attenuate endoplasmic reticulum stress and apoptosis in erastin-induced ferroptosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Cell Biology
Mianqun Zhang, Lei Sun, Zihao Zhang, Luyan Shentu, Yiwen Zhang, Ziyi Li, Yongteng Zhang, Yunhai Zhang
Summary: Arsenite exposure can negatively impact the quality of oocytes, but supplementation of alpha-lipoic acid (ALA) can restore their competency and fertilization capacity. ALA improves the maturation of oocytes, enhances sperm binding ability, reduces oxidative stress, and prevents DNA damage and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Food Science & Technology
Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
Summary: The study demonstrated that alpha-lipoic acid supplementation significantly reduced Malondialdehyde (MDA) levels, but had no significant effect on other antioxidant enzymes and oxidative stress parameters. Overall, it suggested that alpha-lipoic acid supplementation might improve lipid peroxidation, and recommended a daily intake of less than 800 mg for controlling lipid peroxidation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Jae Sang Han, Ye Lin Kim, Hyo Jeong Yu, Jung Mee Park, Yeonji Kim, So Young Park, Shi Nae Park
Summary: The study confirmed the safety and efficacy of α-lipoic acid (ALA) therapy for noise-induced hearing loss, especially through intratympanic administration (IT-ALA), which showed better recovery than intraperitoneal injection (IP-ALA) and intratympanic dexamethasone (IT-DEX) in terms of organ of Corti morphology and hearing levels.
Article
Biochemistry & Molecular Biology
Beata Skibska, Anna Goraca, Agnieszka Skibska, Andrzej Stanczak
Summary: This study evaluated the effects of alpha-lipoic acid (alpha-LA) on oxidative stress parameters and inflammation in the ventricles and atria of the heart in rats. The results suggest that alpha-LA administration can effectively prevent inflammation and oxidative stress in the ventricles and atria of the heart.
Review
Biochemistry & Molecular Biology
Luc Rochette, Steliana Ghibu
Summary: COVID-19, first reported in Wuhan, China in December 2019, has become a global pandemic. Cardiovascular complications have emerged as a major threat in addition to respiratory issues, especially for patients with existing cardiovascular conditions. The mechanisms behind the severe impact of SARS-CoV-2 infection on these patients remain partially understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Max Denisson Mauricio Viana, Pedro Santana Sales Lauria, Alyne Almeida de Lima, Luiza Carolina Franca Opretzka, Henrique Rodrigues Marcelino, Cristiane Flora Villarreal
Summary: Neuropathic pain is a common and debilitating form of chronic pain, with limited effectiveness of current treatments, making the exploration of ALA as a therapeutic agent for managing NP promising. Further research is needed to explore its analgesic mechanisms and clinical applications.