Journal
BIOORGANIC CHEMISTRY
Volume 101, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103950
Keywords
Mangrove-derived; Endophytic fungus; Cladosporium cladosporioides; Sulfur substitution; Biogenetic pathway; Antimicrobial activities
Funding
- National Natural Science Foundation of China [81673351, 31600267]
- Natural Science Foundation of Shandong Province [ZR2016BQ17]
- Taishan Scholar project from Shandong province
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A simple but previously undescribed macrolide with unprecedented bicyclo 5/9 ring system, namely, clado-cladosin A (1), along with two new sulfur-containing macrolides, namely, thiocladospolides F and G (2 and 3), were characterized from the mangrove-derived endophytic fungus Cladosporium cladosporioides MA-299. The structures of these compounds were established on the basis of spectroscopic interpretation, and the absolute configurations of compounds 1-3 were determined by X-ray crystallographic analysis, Mosher's method, and by a biogenetic point of view. The possible biogenetic pathway for compounds 1-3 as well as their congeners thiocladospolides A-D and pandangolide 3 was proposed, providing a role in distinguishing the position of sulfur substitution in thiomacrolides. Compounds 1-3 were evaluated for antimicrobial activities against human-, aquatic-, and plant-pathogenic microbes.
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