Article
Plant Sciences
Jie Shi, Qiang Wu, Jiliang Deng, Kelly Balfour, Zhuo Chen, Yonghua Liu, Sunjeet Kumar, Yanli Chen, Zhixin Zhu, Guopeng Zhu
Summary: JRF leaves of sweetpotato are promising healthy leafy vegetables, and their antioxidant capacity is attributed to the combined action of anthocyanins and other colorless compounds.
Article
Biochemistry & Molecular Biology
B. S. Manoj, Moni Gupta, M. Iqbal Jeelani, Sachin Gupta
Summary: Climate change has caused long-term changes in temperature and weather patterns, leading to unprecedented drought conditions. This study found that by imposing drought stress and applying chitosan treatment, the antioxidant content of red kidney bean seeds can be improved.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Chang Ha Park, Ye Eun Park, Hyeon Ji Yeo, Jeong Su Yoon, Soo-Yun Park, Jae Kwang Kim, Sang Un Park
Summary: The metabolome analysis revealed that the tetraploid mulberry cultivar 'Cheongil' exhibited higher accumulation patterns of both primary and secondary metabolites in their edible parts compared to the diploid cultivar. The results of principal component analyses also showed a clear separation between the diploid and tetraploid groups based on the accumulation of amino acids, carbohydrates, carotenoids, and anthocyanins. This study provides insights into the correlation between primary and secondary metabolites in diploid and tetraploid mulberry cultivars, which can be useful for plant breeding strategies to enhance metabolite biosynthesis through polyploidy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemical Research Methods
Paniz Jasbi, Xiaojian Shi, Ping Chu, Natalie Elliott, Haley Hudson, Douglas Jones, Geidy Serrano, Brandon Chow, Thomas G. Beach, Li Liu, Garilyn Jentarra, Haiwei Gu
Summary: This study conducted metabolomics analysis on brain tissues of dementia patients, identifying metabolite markers that can distinguish different cases, providing important clues for understanding disease mechanisms and identifying therapeutic targets, laying the foundation for future research on the diagnosis and treatment of Alzheimer's disease.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Applied
Elvira Manjon, Siyu Li, Montserrat Duenas, Ignacio Garcia-Estevez, Maria Teresa Escribano-Bailon
Summary: This study evaluated soluble polysaccharides obtained from white and red grape skins as potential modulators of the astringency of red wine. The results showed that polysaccharides from red grape skins significantly decreased astringency and had a greater impact on flavan-3-ols compared to polysaccharides from white grape skins.
Article
Clinical Neurology
Yumi Watanabe, Kensaku Kasuga, Takayoshi Tokutake, Kaori Kitamura, Takeshi Ikeuchi, Kazutoshi Nakamura
Summary: This study utilized mass spectrometry to analyze urine from AD patients and control groups, identifying 26 molecules with significantly different concentrations between the two groups. The orthogonal partial least-squares discriminant analysis showed significant discrimination between AD patients and controls. Pathway analysis revealed alterations in molecules related to glycerolipid and glycerophospholipid metabolism, thermogenesis, and caffeine metabolism in AD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Zhangshun Zhu, Xinmei Zeng, Xiaoqing Shi, Jiao Ma, Xiaoli Liu, Qiang Li
Summary: In this study, we used combined transcriptomics and metabolomics to analyze the genetic and physiological mechanisms of short-term flower color transition in H. mutabilis. We found that specific genes were upregulated or downregulated as the flower color deepened, and identified metabolites associated with flower color change. Our findings suggest that metabolic pathways related to anthocyanin biosynthesis, cysteine and methionine metabolism, and sulfur metabolism are closely related to H. mutabilis flower color transition. This study provides valuable insights for molecular breeding of ornamental cultivars of H. mutabilis.
Article
Horticulture
Chang Ha Park, Wooyeal Ki, Nam Su Kim, Soo-Yun Park, Jae Kwang Kim, Sang Un Park
Summary: This study comprehensively analyzed primary and secondary metabolites in the roots of white and green radishes. The levels of amino acids and phenolic acids were higher in green radishes, while slightly higher levels of glucosinolates were observed in white radishes. Glutamic acid was positively correlated with other amino acids and chlorophylls, while phenylalanine was positively correlated with phenolic compounds. Strong positive correlations were also observed between carbohydrates and phenolics.
Article
Plant Sciences
Yang Ni, Haimei Chen, Di Liu, Lihui Zeng, Pinghua Chen, Chang Liu
Summary: This study identified candidate genes involved in anthocyanin biosynthesis in sugarcane rind through transcriptomic and metabolomic analyses, proposing a pathway for anthocyanin biosynthesis. The results lay the foundation for breeding purple pith sugarcane varieties with high anthocyanin contents.
Article
Food Science & Technology
Silvia Yuste, Iziar A. Ludwig, Maria-Paz Romero, Carme Pinol-Felis, Ursula Catalan, Anna Pedret, Rosa M. Valls, Sara Fernandez-Castillejo, Maria-Jose Motilva, Alba Macia, Laura Rubio
Summary: The study found that supplementation of red-fleshed apple and aronia infusion can have a protective effect on the heart, improve kidney function, and decrease insulin levels. Phenolic compounds composed of anthocyanins, flavan-3-ols, and dihydrochalcones in red- and white-fleshed apples can act synergistically in attenuating cardiovascular outcomes in hypercholesterolemic rats.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Applied
Evangelos Karagiannis, Eirini Sarrou, Michail Michailidis, Georgia Tanou, Ioannis Ganopoulos, Christos Bazakos, Konstantinos Kazantzis, Stefan Martens, Aliki Xanthopoulou, Athanassios Molassiotis
Summary: This study characterized the physicochemical, sensory, and bioactive compound traits of twenty-two sweet cherry accessions in Greece, revealing significant differences in color, taste, and polyphenol content among the evaluated accessions. Certain cultivars showed higher consumer acceptance and polyphenol levels, providing valuable resources for future breeding efforts to improve the nutritional quality traits of sweet cherry cultivars.
Article
Pharmacology & Pharmacy
Mohamed A. Salem, Shahira M. Ezzat, Kawkab A. Ahmed, Saleh Alseekh, Alisdair R. Fernie, Reham M. Essam
Summary: This study aims to determine the best water extraction method for the antihypertensive metabolites of H. sabdariffa and confirm their in vivo antihypertensive capabilities. The results show that both hot and cold water extracts can reduce levels of angiotensin II, ACE, and aldosterone in the plasma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ran Xiao, Rui Liang, Yun-hui Cai, Jie Dong, Lin Zhang
Summary: This study developed an intelligent screening method based on cheminformatics to discover new ingredients for Alzheimer's disease. The research successfully identified a promising compound that showed protective effects on neuronal cells against A beta/Cu2+/AA-induced damage through multiple mechanisms.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Montse Guardiola, Gerard Muntane, Iris Martinez, Lourdes Martorell, Josefa Girona, Daiana Ibarretxe, Nuria Plana, Maria J. Bullido, Elisabet Vilella, Josep Ribalta
Summary: This study identified three variants in PVRL2 that predispose individuals to Alzheimer's disease (AD) while also influencing the lipid profile, increasing cardiovascular risk in patients with type 2 diabetes mellitus (T2DM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Jialong Chen, Heng Ye, Jie Wang, Lu Zhang
Summary: This study classified eight cultivars of H. syriacus into five color lines and two groups based on their flower colors and analyzed the relationship between flower color and anthocyanin components. The results showed that changing the content of specific anthocyanin components may alter the flower color. This research provides scientific guidance and a foundation for molecular breeding of H. syriacus cultivars with new floral colors.
Article
Pharmacology & Pharmacy
Mohamed U. Nooman, Amr S. Al-kashef, Mona M. Rashad, Abd El-Nasser A. Khattab, Kawkab A. Ahmed, Samah S. Abbas
Summary: This study demonstrated that the SLs produced by microbial conversion of Moringa oleifera oil cake significantly reduced oxidative stress, inflammation, and apoptotic markers in rats with AA-induced UC, similar to the reference sulfasalazine.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Mai A. Abd-Elmawla, Eman Abdelalim, Kawkab A. Ahmed, Sherine M. Rizk
Summary: In this study, it was found that pterostilbene and celecoxib combination could effectively alleviate oxaliplatin-induced peripheral neuropathy (OIPN) by interrupting the vicious cycle of inflammation, oxidation, and apoptosis. The combination treatment showed improved behavioral and motor impairments, as well as significant reduction in inflammatory cytokines, oxidative markers, and apoptotic markers.
Article
Medicine, Research & Experimental
Abdallah M. Gendy, Hagar M. El-Sadek, Mohamed M. Amin, Kawkab A. Ahmed, Mohamed Kotb El-Sayed, Alaadin E. El -Haddad, Ayman Soubh
Summary: The study reveals the neuroprotective effect of Glycyrrhizin (Glyc) against experimentally induced Huntington's disease (HD), which is achieved through diverse mechanisms including improvement of neurobehavioral deficits, attenuation of oxidative stress, and reduction of inflammation. The findings provide valuable insights into the potential mechanism of action of Glyc against HD.
Article
Biochemistry & Molecular Biology
Nermeen B. B. Ali, Riham A. A. El-Shiekh, Rehab M. M. Ashour, Sabah H. H. El-Gayed, Essam Abdel-Sattar, Mariam Hassan
Summary: Red onion wastes (ROW) contain bioactive metabolites with potent antimicrobial effects, which were tested against MRSA bacteria in this study. The acidified ethanolic extract of red onion scales (RO-T), as well as its anthocyanin-rich fraction (RO-P) and flavonoid-rich fraction (RO-S), showed promising antibacterial activity. RO-S had the highest activity against MRSA and could eradicate biofilm formation. In vivo assessment using a rat model confirmed the significant reduction of MRSA bacterial load by the RO-T extract and vancomycin.
Article
Immunology
Dalia E. Ali, Marwa M. Abd el-Aziz, Sherihan Salaheldin Abdelhamid Ibrahim, Eman Sheta, Essam Abdel-Sattar
Summary: The study investigated the essential oils (EOs) from the oleoresins of two Araucaria species and found their gastroprotective, anti-inflammatory, antioxidant, and anti-Helicobacter pylori activities. The EOs showed promising effects in protecting against gastric ulcers and reducing inflammation and oxidative stress. These findings are important for preventing the recurrence of peptic ulcers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Sherouk Hussein Sweilam, Fatma Abdel M. Bar, Ahmed I. Foudah, Mohammed H. Alqarni, Omayma D. El-Gindi, Moshera M. El-Sherei, Essam Abdel-Sattar
Summary: This study explored the anti-ulcer and anti-inflammatory effects of E. erinaceus Kit Tan. The extracts and fractions showed significant protection against gastric ulcers and reduced levels of TNF-alpha and IL-6. Two new compounds, erinaceolic acid (E3) and speranskoside (E7), showed strong inhibition against COX-2 and 15-LOX enzymes.
Article
Immunology
Eman M. Elbaz, Reham M. Essam, Kawkab A. Ahmed, Maheera H. Safwat
Summary: This study aimed to investigate the impact of Donepezil on acetic acid-induced ulcerative colitis (UC) in rats. The results showed that Donepezil significantly improved behavioral abnormalities and attenuated inflammation, oxidative stress, and apoptosis in the colitis group. It also inhibited pro-inflammatory cytokines and restored antioxidants levels, demonstrating its potential therapeutic effects on UC and associated neurological disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ghadha Ibrahim Fouad, Kawkab A. Ahmed
Summary: Multiple sclerosis (MS) is a complex neurodegenerative disease with unknown cause, characterized by demyelinated lesions in the brain. Carvedilol and alpha lipoic acid (ALA) showed potential in promoting remyelination and reducing oxidative stress in a CPZ-induced demyelination model. Carvedilol demonstrated pro-remyelinating activity and ALA showed greater neuroprotective potential.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dalia E. Ali, Samar M. Bassam, Soha Elatrebi, Esraa S. Habiba, Eman A. Allam, Eman M. Omar, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Essam Abdel-Sattar
Summary: The study investigated the protective effect of Yucca fruit extract on Parkinson's disease (PD) and found that it has a possible neuroprotective effect. The anti-inflammatory activity of Yucca fruit extracts was explored and the most effective extract was chosen. In vivo investigation on rats confirmed the effectiveness of the extract in improving neurobehavioral and locomotor activities, as well as renal and liver functions. The study suggests Yucca fruit as a promising therapeutic target for PD.
Article
Veterinary Sciences
Mona N. N. Wafy, Elham A. A. Hassan, Kawkab A. A. Ahmed, Amal M. M. Aboelmaaty, Ashraf M. M. Abu-Seida
Summary: The study aimed to describe the ultrasonographic and histopathologic features of ocular diseases in donkeys. A total of 45 donkeys (64 eyes) with ocular diseases were included in the study. Common ocular diseases diagnosed included anterior uveitis, cataract, retinal detachment, and lens and phthisis bulbi. Ultrasonography provided detailed insight into the intraocular structures of the eye, especially in cases with opacification of the dioptric structures.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Sherien M. M. Bakry, Asmaa F. Aboul Naser, Sabri I. El Negoumy, Mona E. S. Kassem, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: Bioactivity-guided fractionation of F. drupacea Thunb. extract revealed that the water fraction (FDWF) increased gastric pH and showed protective effects against ethanol-induced gastric ulcers in rats through antioxidant and anti-inflammatory mechanisms.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mai Hussin Radi, Riham A. A. El-Shiekh, Ali M. M. El-Halawany, Ahmed M. M. Al-Abd, Essam Abdel-Sattar
Summary: This study evaluated the antiproliferative activity of E. grantii aerial parts, and found that the dichloromethane fraction showed promising cytotoxic activity against breast cancer cell lines. Eight compounds were isolated from the active fraction, and euphylbenzoate exhibited the best anticancer activity. These results demonstrate that E. grantii aerial parts contain active compounds with significant antiproliferative potential.
Article
Agriculture, Dairy & Animal Science
Doaa H. H. Assar, Amany E. E. Ragab, Essam Abdelsatar, Abdallah S. S. Salah, Shimaa M. R. Salem, Basma M. M. Hendam, Soad Al Jaouni, Rasha A. A. Al Wakeel, Marwa F. F. AbdEl-Kader, Zizy I. I. Elbialy
Summary: This study investigated the effects of dietary incorporation of olive leaf extract (OLE) on the growth performance, immune response, and antioxidant capacity of common carp (Cyprinus carpio). The results showed that the OLE at a dose of 0.1% improved the growth performance, immune response, and antioxidant capacity of the fish. However, higher doses of OLE should be avoided to prevent oxidative stress.
Article
Chemistry, Multidisciplinary
Ola E. Abdel-Sattar, Rasha M. Allam, Ahmed M. Al-Abd, Ali M. El-Halawany, Ahmed M. EL-Desoky, Shanaz O. Mohamed, Sherouk Hussein Sweilam, Mohammad Khalid, Essam Abdel-Sattar, Meselhy R. Meselhy
Summary: This study aimed to investigate the cytotoxicity and chemomodulatory effects of PN4 and PN5 isolated from Phyllanthus niruri on adriamycin multidrug-resistant breast cancer cells (MCF-7(ADR)) and elucidate their mechanism of action. The results showed that both compounds exhibited moderate potency against MCF-7 and MCF-7(ADR), and significantly synergized the anticancer properties of DOX. The chemomodulatory effect of both compounds was achieved through promoting DOX-induced cell cycle interference and apoptosis induction.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)