Article
Chemistry, Multidisciplinary
Thomashire A. George, Max M. Chen, Andreas Czosseck, Hsiang-Pei Chen, Hsu-Shan Huang, David J. Lundy
Summary: Triple negative breast cancer (TNBC) is a highly aggressive subtype that is challenging to treat, with small molecule-based chemotherapy being the preferred course of treatment. However, these drugs have high toxicity and tumors may develop resistance.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Applied
Milad Jafarpour, Milad Fathi, Nafiseh Soltanizadeh
Summary: Encapsulated PCM has been developed for thermal buffering in food packaging. The encapsulated PEG exhibited decreased crystallization temperature and melting enthalpy. The encapsulation process improved the thermal stability of PCM. Encapsulated PCM was effective in controlling temperature fluctuation and preserving the quality of perishable food.
FOOD HYDROCOLLOIDS
(2023)
Article
Biophysics
Jana Szabova, Ondrej Misik, Martina Havlikova, Frantisek Lizal, Filip Mravec
Summary: This study investigated the effects of cholesterol, phosphatidic acid, and polyethylene glycol on the stability and properties of liposomes. Results showed that cholesterol increased membrane fluidity for liposome stabilization, while higher amounts of PEG were needed for successful steric stabilization. The nebulization process slightly influenced immobilized water and the rigidity of the inner part of the membrane for the two lowest concentrations of PEG.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Teresa De Toni, Aaron A. Stock, Floriane Devaux, Grisell C. Gonzalez, Kailyn Nunez, Jessica C. Rubanich, Susan A. Safley, Collin J. Weber, Noel M. Ziebarth, Peter Buchwald, Alice A. Tomei
Summary: Pancreatic islet transplantation improves metabolic control and prevents complications in patients with brittle type 1 diabetes (T1D). Islet encapsulation can eliminate the need for immunosuppression. This study analyzed two microencapsulation platforms and found that capsule size and permselective materials affect insulin secretion. Anti-inflammatory modulation may be beneficial for small conformal capsules.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Tiantian Xu, Jingwen Zhang, Risheng Jin, Rong Cheng, Xiaonan Wang, Chuanxun Yuan, Changsheng Gan
Summary: The study found that co-encapsulated liposomes have higher antioxidant activity and bioavailability compared to single loaded liposomes, especially in potential applications in functional foods.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Pharmacology & Pharmacy
Yu Sakurai, Miho Suzuoki, Masaki Gomi, Hiroki Tanaka, Hidetaka Akita
Summary: The study found that phosphatidylserine (PS)-containing anionic liposomes were more easily taken up by macrophages and more selectively accumulated in sentinel lymph nodes. Through Design-of-Experiment, a new lipid composition was identified to enhance the selectivity of liposome accumulation in sentinel lymph nodes. The optimized PS-containing particles showed more selectivity in accumulating in SLN lymph nodes compared to existing imaging agents.
Article
Chemistry, Multidisciplinary
Lok Hin Law, Jianpan Huang, Peng Xiao, Yang Liu, Zilin Chen, Joseph H. C. Lai, Xiongqi Han, Gerald W. Y. Cheng, Kai-Hei Tse, Kannie W. Y. Chan
Summary: Image guided nose-to-brain drug delivery is a non-invasive method to monitor drug delivery to the brain. This study investigated the imaging of liposome-based drug delivery to the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). Liposomes loaded with a computed tomography (CT) contrast agent were administered intranasally and specific CEST contrasts were observed in the olfactory bulb and frontal lobe.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ahlem Meziadi, Navid Zuberi, Hendrick W. de Haan, Marc A. Gauthier
Summary: This study reveals that the inefficiency of bioconjugation reactions, such as protein PEGylation, is caused by the excluded volume effect (EVE) between methoxy poly(ethylene glycol) (mPEG) and proteins. The researchers found that this EVE leads to the self-assembly of proteins and reactive mPEG into separate protein-rich and mPEG-rich domains. By adding unreactive low-molecular weight mPEG as a co-solvent, the association between the larger protein and reactive mPEG can be promoted, resulting in improved reaction efficiency.
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Medicine, Research & Experimental
Tien-Ching Chang, Bing-Mae Chen, Jer-Yuan Wu, Tian-Lu Cheng, Steve Roffler
Summary: Antibodies that bind polyethylene glycol (PEG) can accelerate the clearance of pegylated medicines, with higher affinity antibodies leading to greater clearance and reduced drug efficacy. The molar ratio of high affinity anti-PEG antibodies to PEG-EPO correlates with accelerated blood clearance in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Hoon Hyun, Min Ho Park, Gayoung Jo, Bo Young Lee, Jae Won Choi, Heung Jae Chun, Hyeon Soo Kim, Dae Hyeok Yang
Summary: The study developed a novel drug carrier for breast cancer therapy, with MGC/CDPF-ic-PTX showing promising anti-cancer effects, enhanced cellular uptake, sustained release, and potential therapeutic efficacy against breast cancer.
Article
Multidisciplinary Sciences
Chintan Savla, Andre F. Palmer
Summary: This study investigates the long-term storage stability of extracellular mega-hemoglobin from the annelid Lumbricus terrestris and proposes a reliable freeze-drying strategy for re-solubilization. The findings suggest that lyophilization and storage in specific conditions can significantly enhance storage lifetime of hemoglobin-based oxygen carriers.
Article
Agricultural Engineering
Hatice Cagla Pan, Suleyman Polat
Summary: This study encapsulated limonene using liposome and cyclodextrin inclusion methods to produce active hutbak papers. The physical properties of the papers were analyzed and the antifungal activity of the papers was measured. The results showed that the production methods had an impact on the properties of the papers. The analysis of limonene content and antifungal activity showed some samples had active properties.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Food Science & Technology
Wahyudiono, Jiayang He, Xin Hu, Siti Machmudah, Keiji Yasuda, Seiichi Takami, Hideki Kanda, Motonobu Goto
Summary: Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2)-ultrasound environment system. The operating conditions influenced the size of liposome products and the encapsulation efficiency of curcumin. This innovative method does not require organic solvents and is practical for generating liposomes.
Article
Chemistry, Multidisciplinary
Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Summary: Protein therapeutics, especially those with PEG decoration, face challenges of short half-life and immunogenicity. The authors developed a poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) conjugate to improve the stability and immunogenicity of PEGylated proteins. The uricase-POEGMA conjugate demonstrated enhanced pharmacokinetics and reduced immunogenicity compared to traditional PEGylated proteins.
