Journal
BIOMATERIALS
Volume 245, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119976
Keywords
Photothermal therapy; Low temperature; Polydopamine coating; Gene silencing; RNase resistance; siRNA delivery
Funding
- National Key Research and Development Program of China [2018YFC1106100, 2018YFC1106102]
- National Natural Science Foundation of China [21661162001, 21673139, 51690151, 51473093, 81822024]
- Special Program for Collaborative Innovation in Shanghai University of Medicine AMP
- Health Sciences [SPCI-17-15-001]
Ask authors/readers for more resources
Photothermal therapy (PTT) normally requires to maintain the temperature of tumor lesions above 50 degrees C, which potentially induces local inflammation and tumor metastasis. To avoid these side effects, it is vital to achieve effective antitumor efficacy at relatively low temperature (42-45 degrees C) during the PTT treatment. Herein, we design a polydopamine (PDA)-coated nucleic acid nanogel as a therapeutic complex for siRNA-mediated low-temperature PTT. First, siRNAs that target the heat-shock-protein 70 (Hsp70) serve as crosslinkers to guide the DNA-grafted polycaprolactone (DNA-g-PCL) assemble into nanosized hydrogel particles through nucleic acid hybridization. Thereafter, the obtained siRNA-embedded nanogels are further coated with a thin layer of polydopamine, which not only protects the nanogels against enzymatic degradation but also endows the nanogels with excellent photothermal conversion capacity under near infrared (NIR) light irradiation. After surface PEGylation, this triple shield siRNA delivery complex shows the capability of effective ablating the tumor under relatively mild condition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available