Article
Biochemistry & Molecular Biology
Yi Cai, Melissa Johnson, A. Sigen, Qian Xu, Hongyun Tai, Wenxin Wang
Summary: A study reports an injectable and self-healable hydrogel formed by a combination of hyperbranched PEG-based material and aldehyde-functionalized hyaluronic acid, with gelatin added to enhance cell activity, exhibiting characteristics such as rapid gel-sol transition, shear-thinning, and self-healing properties.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Reihaneh Haghniaz, Hossein Montazerian, Atiya Rabbani, Avijit Baidya, Brent Usui, Yangzhi Zhu, Maryam Tavafoghi, Fazli Wahid, Han-Jun Kim, Amir Sheikhi, Ali Khademhosseini
Summary: In this study, an injectable, photocrosslinkable, and stretchable hydrogel sealant based on GelMA supplemented with antibacterial ZF nanoparticles and hemostatic SNs was developed. The hydrogel reduced the in vitro viability of Staphylococcus aureus by over 90% and improved the burst pressure of perforated ex vivo porcine lungs by more than 40%. It also reduced bleeding by over 50% in rat bleeding models. This nanoengineered hydrogel has great potential for effectively sealing complex wounds that require mechanical flexibility, infection management, and hemostasis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Wan-Chun Chang, Au-Zou Tai, Nian-Yun Tsai, Yi-Chen Ethan Li
Summary: The study synthesized an injectable and photo-crosslinkable bioadhesive made of gelatin methacryloyl and phenyl isothiocyanate-modified gelatin, offering good hemostatic properties and adjustable mechanical properties.
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: A bioactive hydrogel is developed for efficient and safe bacteria-infected diabetic wound healing by targeting inflammation and infection. The hydrogel can capture danger molecules and deliver antibiotics, resulting in improved wound closure rate and anti-inflammatory and antibacterial effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: This study introduces a bioactive hydrogel, named OCMC-Tob/PEI hydrogel, for the treatment of infected wounds in patients with chronic diabetes. The hydrogel achieves dual effects of anti-inflammation and anti-infection by scavenging danger molecules and releasing antibiotics.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Yao Chen, Yu Xiang, Tonghe Zhu, Sihao Chen, Juan Du, Jiajia Luo, Xiaoyu Yan
Summary: A photocrosslinked physicochemical double-network hydrogel with excellent mechanical properties, antibacterial activity, and injectable properties was prepared, which showed promising potential in the treatment of chronic wounds and accelerating wound healing.
Article
Biochemistry & Molecular Biology
Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Razvan Ghiarasim, Alexandru Rotaru
Summary: A facile method for preparing beta-cyclodextrin-functionalized hydrogels based on guanosine quartet assembly was discussed. The ratio of beta-cyclodextrin and guanosine components significantly influenced the internal structuration and mechanical properties of the hydrogels. The hydrogels showed potential for specific applications in biomedical and pharmaceutical fields, with self-healing and thixotropic properties and selective antimicrobial activity against S. aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Yuting Cao, Yan Zhou, Jinbin Pan, Xinyu Zhong, Jianmin Ding, Xiang Jing, Shao-Kai Sun
Summary: A general strategy for designing an injectable microwave-sensitive immune hydrogel was proposed for the first time, with characteristics including easy synthesis process, high microwave-sensitivity, good encapsulation efficiency, biocompatibility, syringeability, and large-scale production capability.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Zheng Zou, Zhen Zhang, Hui Ren, Xueliang Cheng, Xuesi Chen, Chaoliang He
Summary: An antibacterial tissue-adhesive hydrogel was developed by mixing OPA-terminated four-arm poly(ethylene glycol) and e-poly-L-lysine solutions. The hydrogel showed tunable gelation time, storage moduli, and degradation rate. It exhibited excellent antibacterial activity, good biocompatibility, and strong tissue adhesion, making it a promising wound dressing for infection prevention and wound healing promotion.
Article
Pharmacology & Pharmacy
Marzieh Mohammadi, Malihe Karimi, Bizhan Malaekeh-Nikouei, Mohammad Torkashvand, Mona Alibolandi
Summary: Injectable in situ forming hydrogels are efficient local drug delivery systems for cancer therapy. They can provide sustained release of chemotherapeutics and potentially prevent post-surgical cancer recurrence. Various materials and crosslinking chemistry can be used to fabricate hybrid hydrogels with different characteristics, such as stimuli-sensitive platforms or multifunctional systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Junqing Zhang, Shuang Zhao, Shen Zhang, Hao Zhu, Yaoxin Zhang, Linpei Li, Chaoqun Liu, Jiahua Shi
Summary: In this study, a nanozyme-reinforced injectable hydrogel was prepared for oxygen self-sufficient photodynamic therapy (PDT) to eradicate biofilm infection. The hybrid hydrogel exhibited high-performance bactericidal activity against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, and showed great efficacy in eliminating biofilm infection. The hydrogel has good syringeability and high efficiency in promoting wound healing in a biofilm-infected mice model.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Multidisciplinary
Zeynep Cimen, Sena Babadag, Sedat Odabas, Sevde Altuntas, Gokhan Demirel, Gokcen Birlik Demirel
Summary: Injectable, self-healable, and pH-responsive hybrid hydrogels offer a promising potential for controlled and long-term drug release in cancer treatment. The gelation time is short, with excellent injectability and self-healing capability, alongside outstanding gelation stability. The hybrid hydrogels also exhibit efficient pH-dependent drug release and excellent biocompatibility with support for cell proliferation.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Applied
Yang Yang, Yuting Zhou, Yuanli Li, Liangyu Guo, Juan Zhou, Jinghua Chen
Summary: A new injectable self-healing hydrogel has been developed with antibacterial and wound healing properties, showing quick and efficient antibacterial potency as well as excellent biocompatibility in vitro. The hydrogels also demonstrated the ability to promote cell migration and wound healing potential in scratch-wound assays.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Immunology
James B. Brock, Peyton Herrington, Melissa Hickman, Aubri Hickman
Summary: This study reports the successful viral suppression in 12 patients with persistent viremia who were unable to maintain suppression on oral antiretroviral therapy, through the use of injectable cabotegravir/rilpivirine (iCAB/RPV). No virologic rebound was observed in any of the patients. iCAB/RPV can be considered as an alternative option for patients unable to maintain suppression on oral antiretroviral therapy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Review
Engineering, Biomedical
Arwa Daghrery, Isaac J. de Souza Araujo, Miguel Castilho, Jos Malda, Marco C. Bottino
Summary: For almost three decades, tissue engineering strategies have been used to create effective therapies for dental, oral, and craniofacial regenerative medicine by treating permanent deformities caused by debilitating health conditions. Additive manufacturing techniques, such as melt electrowriting (MEW), enable the creation of personalized scaffolds that can replicate native tissue characteristics using 3D printing technology. Recent advancements have shown that combining MEW with other biofabrication techniques can overcome some limitations and offer promising opportunities for tissue regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Isaac J. de Souza Araujo, Tamannaben Patel, Amal Bukhari, Carolina K. Sanz, J. Christopher Fenno, Juliana S. Ribeiro, Marco C. Bottino
Summary: This investigation synthesized poly(d,l-lactide) (PLA)-based fibrous scaffolds containing natural essential oils and evaluated their antimicrobial properties and cytocompatibility for regenerative endodontics. The results showed that the incorporation of natural monoterpenes did not affect the scaffold's fibrous morphology and demonstrated significant antimicrobial activity against endodontic pathogens, while maintaining cell viability.
Article
Engineering, Biomedical
Arwa Daghrery, Jessica A. Ferreira, Jinping Xu, Nasim Golafshan, Darnell Kaigler, Sarit B. Bhaduri, Jos Malda, Miguel Castilho, Marco C. Bottino
Summary: This study engineered scaffolds with specific fiber morphology and structures to guide the differentiation of periodontal ligament stem cells and mediate macrophage polarization. The results showed that aligned fiber scaffolds can promote the formation of periodontal ligament, while fluorinated calcium phosphate-coated fibers with specific strand spacings can enhance bone tissue regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Minzhi Yu, Wenmin Yuan, Ziyun Xia, Yayuan Liu, Yan Wang, Xiaoming Xu, Jiwen Zheng, Anna Schwendeman
Summary: In this study, a panel of analytical methods was developed to characterize Exparel in terms of particle size, drug and lipid content, residual solvents, and pH. An accelerated in vitro drug release assay was also developed. The batch-to-batch variability of Exparel was examined, showing good consistency in drug content, particle size, pH, and in vitro drug release kinetics, with slight variation in lipid content.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Joana Rita Oliveira Faria Marques, Patricia Gonzalez-Alva, Ruby Yu-Tong Lin, Beatriz Ferreira Fernandes, Akhilanand Chaurasia, Nileshkumar Dubey
Summary: Cancer treatment development is complex due to tumor heterogeneity and inter-patient variations. Traditional 2D cell culture is insufficient to mimic tumor-specific architecture, while 3D culture techniques and bioprinting have shown promise in bridging the gap.
Article
Medicine, Research & Experimental
Minzhi Yu, Kristen Hong Dorsey, Troy Halseth, Anna Schwendeman
Summary: Phosphatidylserine (PS) is an anionic phospholipid component in high-density lipoprotein (HDL) with intrinsic anti-inflammatory effects. Incorporating PS in synthetic HDLs (sHDLs) improve particle stability and enhance anti-inflammatory effects on macrophages and endothelial cells. PS has no negative impact on cholesterol efflux capacity and pharmacokinetic profiles of sHDLs. PS-containing sHDLs show therapeutic potential for inflammation resolution in atherosclerosis and other inflammatory diseases.
MOLECULAR PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Priscila T. A. Toledo, Caroline Anselmi, Renan Dal-Fabbro, Abdel H. Mahmoud, Alexandra K. Abel, Matthew L. Becker, Alberto C. B. Delbem, Marco C. Bottino
Summary: The aim of this study was to create and evaluate biodegradable polymer-based nanofibers incorporating different concentrations of calcium trimetaphosphate (Ca-TMP) for periodontal tissue engineering. The fibers were fabricated using electrospinning technique and characterized using various techniques. The addition of Ca-TMP improved the degradation stability and dimensional stability of the fibers without compromising their mechanical properties. Although Ca-TMP extracts enhanced cell viability and alkaline phosphatase activity, there was no significant difference between the scaffold groups in terms of cell function.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Arwa Daghrery
Summary: This in vitro study evaluated the effects of artificial aging on the color, gloss, and surface roughness of 3D-printed veneers. The results showed that artificial aging led to increased color changes, surface roughness, and reduced gloss in all materials. Moreover, the 3D-printed veneers exhibited higher color changes and surface roughness compared to the prefabricated resin composite veneer systems.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Biomaterials
Nileshkumar Dubey, Juliana S. Ribeiro, Zhaocheng Zhang, Jinping Xu, Jessica A. Ferreira, Liu Qu, Ling Mei, J. Christopher Fenno, Anna Schwendeman, Steven P. Schwendeman, Jacques E. Nor, Marco C. Bottino
Summary: Regenerative endodontics is a paradigm shift in treating necrotic young permanent teeth. This study developed a hydrogel system that combines antimicrobial and angiogenic properties while minimizing cell toxicity. The engineered hydrogels demonstrated antibiotic-dependent inhibition of bacterial growth and enhanced angiogenesis in vitro and in vivo. This research highlights the clinical potential of antibiotic-eluting gelatin methacryloyl hydrogel for regenerative endodontics.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biotechnology & Applied Microbiology
Lara Rodrigues Schneider, Andressa da Silva Barboza, Juliana Silva Ribeiro de Andrade, Daniela Coelho dos Santos, Carlos Enrique Cuevas-Suarez, Evandro Piva, Angela Diniz Campos, Rafael Guerra Lund
Summary: This study evaluated the antimicrobial activity and physicochemical properties of a new dual-cure endodontic sealer containing copaiba oil. Copaiba oil was characterized by gas chromatography and its minimum inhibitory concentration was determined. The antimicrobial activity of the sealers was evaluated by direct contact test, while the physicochemical properties were assessed through various tests. The sealers containing copaiba oil showed antimicrobial activity without compromising their physicochemical properties.
Article
Materials Science, Multidisciplinary
Erfan Rezvani Ghomi, Rajamani Lakshminarayanan, Vijila Chellappan, Navin Kumar Verma, Amutha Chinnappan, Rasoul Esmaeely Neisiany, Kottaiswamy Amuthavalli, Zhi Sheng Poh, Brandon Han Siang Wong, Nileshkumar Dubey, Roger Narayan, Seeram Ramakrishna
Summary: This study demonstrates that aligned PCL/gelatin mats containing epsilon-PL have broad antimicrobial activity and excellent biocompatibility, making them promising for potential use in wound dressings.
ADVANCED FIBER MATERIALS
(2023)
