Preclinical contraceptive development for men and women

Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods

(2019) Jill E. Long et al.   CLINICAL CHEMISTRY

Unpackaging the genetics of mammalian fertility: strategies to identify the “reproductive genome”†

(2018) John C Schimenti et al.   BIOLOGY OF REPRODUCTION

Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

(2018) Damir Bojadzic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Genome-wide association study identifiesERBB4on 2q34 as a novel locus associated with sperm motility in Japanese men

(2018) Youichi Sato et al.   JOURNAL OF MEDICAL GENETICS

Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception

(2018) Shameem Sultana Syeda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological modulation of the CO 2 /HCO 3 − /pH-, calcium-, and ATP-sensing soluble adenylyl cyclase

(2018) Shakarr V. Wiggins et al.   PHARMACOLOGY & THERAPEUTICS

A Quantitative Disintegration Method for Polymeric Films

(2018) Sheila Grab et al.   Journal of Pharmaceutical Innovation

An overview of properties of Amphora (Acidform) contraceptive vaginal gel

(2018) Anita L. Nelson   Expert Opinion On Drug Safety

Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases

(2018) Sharanya Sarkar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting

(2018) Sarder Arifuzzaman et al.   PHARMACOLOGICAL RESEARCH

An intravaginal ring for real-time evaluation of adherence to therapy

(2017) John A. Moss et al.   PLoS One

Pipeline for contraceptive development

(2016) Diana L. Blithe   FERTILITY AND STERILITY

Sequence variation atKLKandWFDCclusters and its association to semen hyperviscosity and other male infertility phenotypes

(2016) Patrícia Isabel Marques et al.   HUMAN REPRODUCTION

Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs

(2016) Cassilda Cunha-Reis et al.   JOURNAL OF CONTROLLED RELEASE

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

(2016) Lavoisier Ramos-Espiritu et al.   Nature Chemical Biology

ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception

(2016) Matteo A. Avella et al.   Science Translational Medicine

Phosphodiesterase 3 (PDE3) inhibition with cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta)

(2015) Carol B. Hanna et al.   CONTRACEPTION

A Temperature-Monitoring Vaginal Ring for Measuring Adherence

(2015) Peter Boyd et al.   PLoS One

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

(2014) Susanne M. Saalau-Bethell et al.   ChemMedChem

Formulation and Characterization of Polymeric Films Containing Combinations of Antiretrovirals (ARVs) for HIV Prevention

(2014) Ayman Akil et al.   PHARMACEUTICAL RESEARCH

Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

(2013) John A. Moss et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vaginal Films for Drug Delivery

(2013) Rita M. Machado et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Current status of contraceptive vaginal rings

(2012) Vivian Brache et al.   CONTRACEPTION

Contraception by induction of luteinized unruptured follicles with short-acting low molecular weight FSH receptor agonists in female animal models

(2011) R van de Lagemaat et al.   REPRODUCTION

The search for SNPs, CNVs, and epigenetic variants associated with the complex disease of male infertility

(2011) Douglas T. Carrell et al.   Systems Biology in Reproductive Medicine

WEE2 Is an Oocyte-Specific Meiosis Inhibitor in Rhesus Macaque Monkeys1

(2010) Carol B. Hanna et al.   BIOLOGY OF REPRODUCTION

Contraceptive vaginal rings: a review

(2010) Vivian Brache et al.   CONTRACEPTION

Na,K-ATPase  4 isoform is essential for sperm fertility

(2010) T. Jimenez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility

(2009) Nashmil Emami et al.   BIOLOGICAL CHEMISTRY

Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice1

(2009) Polina V. Danshina et al.   BIOLOGY OF REPRODUCTION

Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: initial trials

(2009) Jeffrey T. Jensen et al.   CONTRACEPTION

Genome-Wide Study of Single-Nucleotide Polymorphisms Associated With Azoospermia and Severe Oligozoospermia

(2009) K. I. Aston et al.   JOURNAL OF ANDROLOGY

Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility1

(2008) Fanny Odet et al.   BIOLOGY OF REPRODUCTION

Seminal hyperviscosity is associated with poor outcome of in vitro fertilization and embryo transfer: a prospective study

(2008) Navid Esfandiari et al.   FERTILITY AND STERILITY

Determinants of the Rate and Extent of Spermatogenic Suppression during Hormonal Male Contraception: An Integrated Analysis

(2008) Peter Y. Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells

(2008) D. S. Johnston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA