Article
Nutrition & Dietetics
Carles Lerin, Maria Carmen Collado, Elvira Isganaitis, Erland Arning, Brandi Wasek, Ellen W. Demerath, David A. Fields, Teodoro Bottiglieri
Summary: The concentration of S-adenosylmethionine (SAM) is higher in breast milk compared to other biofluids and is absent in infant milk formulas. This may suggest a strong demand for this metabolic nutrient during infant early growth.
Article
Cardiac & Cardiovascular Systems
Sophia D. Amenyah, Mary Ward, Amy McMahon, Jennifer Deane, Helene McNulty, Catherine Hughes, J. J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh, Diane J. Lees-Murdock
Summary: This study found that individuals with the MTHFR 677TT v CC genotype had higher DNA methylation levels at NOS3. In TT individuals who received riboflavin supplementation, DNA methylation levels increased at IGF2 and decreased at ACE. Specific CpG sites were found to be hypomethylated in GNA12 and hypermethylated in AGTR1.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Surgery
Mikyung Kim, Yunmee Rho, Rhoeun Park, Jeeyoun Jung, Geum-Sook Hwang, Youn Kyoung Seo, Ji Hae Seo, Yoonseok Heo, Tae Kyung Ha, Eunyoung Ha
Summary: The study shows that duodenal-jejunal bypass (DJB) surgery can reduce hepatic steatosis and improve insulin sensitivity by altering 1-carbon metabolism flux, thereby preventing diet-induced fatty liver disease. This improvement may involve decreasing the SAM-to-S-adenosylhomocysteine ratio and regulating the expression of SAM metabolizing enzymes.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Review
Plant Sciences
Mutsumi Watanabe, Yukako Chiba, Masami Yokota Hirai
Summary: The review discusses the metabolism and regulatory functions of key metabolites in the plant metabolic network related to sulfur-containing amino acids and compares them with microbial and animal metabolism, highlighting specific differences in plant metabolism.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Oncology
Michael J. Koenig, Bernice A. Agana, Jacob M. Kaufman, Michael F. Sharpnack, Walter Z. Wang, Christoph Weigel, Fabio C. P. Navarro, Joseph M. Amann, Nicole Cacciato, Rajeswara Rao Arasada, Mark B. Gerstein, Vicki H. Wysocki, Christopher Oakes, David P. Carbone
Summary: The study discovered a novel association between LKB1 loss and widespread DNA demethylation in lung adenocarcinoma, leading to global hypomethylation with implications for epigenetic therapy and immunotherapy in these cancers.
Article
Food Science & Technology
Xinhui Zhang, Jing Xu, Mingzhu Wang, Chengyan Gan, Yuan Ren, Xueqing Zhao, Zhaohe Yuan
Summary: Riboflavin treatment delays senescence and decay of strawberries by maintaining energy level and regulating metabolic pathways.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aida Corrillero Bravo, Maria Nieves Ligero Aguilera, Nahuel R. Marziali, Lennart Moritz, Victoria Wingert, Katharina Klotz, Anke Schumann, Sarah C. Gruenert, Ute Spiekerkoetter, Urs Berger, Ann-Kathrin Lederer, Roman Huber, Luciana Hannibal
Summary: S-adenosylmethionine (SAM) is essential for methyl transfer reactions. SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases. Measurement of SAM and SAH in plasma is valuable for diagnosing inborn errors of metabolism and assessing methyl group homeostasis.
Article
Nutrition & Dietetics
Shuying Li, Xiubiao Tian, Yiyun Wang, Xumei Zhang, Liwen Zhang, Chen Li, Jing Li, Chunhua Wang, Huihuan Liu, Juan Liu, Hongjuan Liu, Xueli Yang, Weiqin Li, Junhong Leng, Xilin Yang, Naijun Tang, Qiang Zhang
Summary: This study found that higher folate concentrations were associated with increased risk of GDM, while higher B-12 concentrations were associated with reduced risk. Pregnancies with the MTHFR rs1801131 TT genotype were more susceptible to OCM nutrient-related GDM.
Article
Biochemistry & Molecular Biology
Arturo Reyes Palomares, Maximiliano Ruiz-Galdon, Kui Liu, Armando Reyes-Engel, Kenny A. Rodriguez-Wallberg
Summary: This study evaluated the impact of gene variants related to folate metabolism on the success of IVF treatment in women receiving donated oocytes, finding that these variants did not have a direct impact on pregnancy conception after IVF, but could influence pregnancy loss events or pregnancy maintenance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yue-tao Chen, Ke-xin Yang, Zhen-yuan Dai, Huan Yi, Xuan-xian Peng, Hui Li, Zhuang-gui Chen
Summary: The study found that the central carbon metabolism is repressed in SCF-resistant Pseudomonas aeruginosa, along with a decrease in related riboflavin metabolism and other metabolic pathways such as fatty acid biosynthesis and glutamate metabolism. The reduced riboflavin metabolism is linked to ROS generation, contributing to SCF resistance, but increasing ROS levels can restore SCF sensitivity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Wenrui Wang, Huimin Zhao, Nanhai Yu, Fan Chen, Min Dong
Summary: In this study, a stable fluoro decarboxyl SAM (F-dcSAM) analogue was designed and synthesized for enzymatic fluoromethylation. The results showed that F-dcSAM is a universal abiological cofactor of methyltransferases, which can improve the metabolic stability and biological activity of compounds and facilitate the preparation of fluoro analogues of drug molecules.
Article
Plant Sciences
Yu Li, Wangdan Xiong, Feng He, Tianxiong Qi, Zhen Sun, Yuchen Liu, Shiqie Bai, Honglun Wang, Zhenying Wu, Chunxiang Fu
Summary: The down-regulation of PvSAMS in switchgrass can reduce the contents of SAM, G-lignins, and S-lignins, leading to the accumulation of methionine and glucoside derivatives of caffeoyl alcohol, and resulting in brownish stems. Transcriptomic analysis shows that most sulfur deficiency-responsive genes are differentially expressed in the transgenic switchgrass, leading to an increase in total sulfur content.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Nutrition & Dietetics
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Summary: The study suggests a protective effect of riboflavin intake against gastric cancer, especially in females and individuals with MTRR (rs1532268) genetic variants. Low riboflavin intake in T+ carriers may significantly increase the risk of gastric cancer.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Ahlam Abuawad, Anne K. Bozack, Roheeni Saxena, Mary Gamble
Summary: The one-carbon metabolism-related micronutrients play a critical role in arsenic methylation, toxicity, and associated health outcomes. Folate has been shown to impact arsenic methylation, but the effects of other micronutrients are less studied and require further research.
Article
Nutrition & Dietetics
Gemma Rodriguez-Carnero, Paula M. Lorenzo, Ana Canton-Blanco, Leire Mendizabal, Maddi Arregi, Mirella Zulueta, Laureano Simon, Manuel Macia-Cortinas, Felipe F. Casanueva, Ana B. Crujeiras
Summary: This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes in a group of pregnant women in Spain and found that these polymorphisms were associated with maternal and neonatal outcomes.
Article
Nutrition & Dietetics
Oonagh C. Lyons, Maeve A. Kerr, Helene McNulty, Fiona Ward, Janette Walton, M. Barbara E. Livingstone, Breige A. McNulty, Laura Kehoe, Pamela A. Byrne, Ita Saul, Mary A. T. Flynn
Summary: This study establishes a protocol for addressing nutrient shortfalls among 1- to 5-y-old children by analyzing dietary patterns. The majority of children in this age group do not meet the recommended intake for important nutrients such as vitamin D, vitamin E, DHA+EPA, and fiber. The intake of free sugars also exceeds the recommended limits. Only the milk-feeding scenario of human milk + cow milk can address the DHA+EPA deficiency in 1-3-year-olds. Iron and vitamin E deficiencies are most prevalent in children below the 25th growth percentile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Charles E. Seaks, Erica M. Weekman, Tiffany L. Sudduth, Kevin Xie, Brandi Wasek, David W. Fardo, Lance A. Johnson, Teodoro Bottiglieri, Donna M. Wilcock
Summary: Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia. The Apolipoprotein E (ApoE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease and is also a risk factor for VCID. Mice with the ApoE ε4 allele show significant resistance to hyperhomocysteinemia (HHcy) induction, with differences in homocysteine metabolism and methylation cycle compared to mice with the ε3 allele. There are also significant differences in inflammatory profiles between ε3 and ε4 mice, as well as reduced expression of the serine protease inhibitor Serpina3n in ε4 HHcy mice. Lastly, there is evidence of pervasive sex differences in response to HHcy induction within both genotypes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Nutrition & Dietetics
Karel Kalecky, Paula Ashcraft, Teodoro Bottiglieri
Summary: This study explores the alterations in one-carbon metabolism in Alzheimer's disease (AD) and Parkinson's disease (PD), and finds a potential link between levodopa-carbidopa therapy and dementia in PD patients, as well as the correlation between betaine and cognitive score in PD patients.
Article
Medicine, General & Internal
Thaddaeus May, Bethany de la Haye, Gabrielle Nord, Kevin Klatt, Kevin Stephenson, Sara Adams, Lucy Bollinger, Neil Hanchard, Erland Arning, Teodoro Bottiglieri, Kenneth Maleta, Mark Manary, Farook Jahoor
Summary: The study found distinct differences between kwashiorkor and marasmic-kwashiorkor due to dysfunction in one-carbon metabolism. Observations suggest that methionine deficiency may drive this dysfunction, leading to the pathogenesis of the syndrome. The results indicate that further investigation into fortifying diets with methionine and nutrients supporting efficient methionine use could be crucial for preventing this syndrome.
Article
Nutrition & Dietetics
Guy-Marino Hinnouho, Daniela Hampel, Setareh Shahab-Ferdows, Maxwell A. Barffour, Liadhan McAnena, Charles D. Arnold, K. Ryan Wessells, Sengchanh Kounnavong, Lindsay H. Allen, Helene McNulty, Sonja Y. Hess
Summary: The study found that daily use of a multiple micronutrient powder (MNP) for 9 months only affected the folate status of young Laotian children, with no improvement in thiamine, riboflavin, or B-12 status.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Neurosciences
Karel Kalecky, Dwight C. German, Albert A. Montillo, Teodoro Bottiglieri
Summary: In this study, metabolic changes in Alzheimer's disease (AD) were investigated in plasma and frontal brain cortex tissue samples, revealing disturbances in multiple pathways including microbiome-related metabolites, methylhistidine metabolism, polyamines, and lipids. Elevated triglycerides were observed in plasma of AD patients, while altered amino acid metabolism was found in the cortex. Plasma metabolites showed potential as biomarkers for predicting AD, with specific accuracy for females. Targeting multiple metabolic areas, including microbiome composition and hormonal balance, may offer new intervention strategies for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Oonagh C. Lyons, Mary A. T. Flynn, Clare A. Corish, Eileen R. Gibney, Maeve A. Kerr, Malachi J. McKenna, Helene McNulty, Emeir M. McSorley, Anne P. Nugent, Claire O'Brien, Mary Ward, Katherine M. Younger, Ita Saul
Summary: Ensuring the nutritional well-being of older adults is critically important, and specific dietary guidelines are needed for elderly individuals living independently. In Ireland, a large percentage of older adults are overweight or obese, highlighting the importance of addressing these issues. Updating nutrient intake goals and considering specific nutritional concerns of aging, such as muscle preservation, weight management, fortified foods, and vitamin D supplementation, are crucial in developing appropriate dietary guidelines for this population.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2022)
Article
Oncology
Miroslava Ondicova, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty, Colum P. Walsh
Summary: This study reveals clear alterations in DNA methylation at specific neurodevelopmental genes in children born to mothers who were supplemented with folic acid during pregnancy. These changes play an important role in transcriptional regulation and provide supporting evidence for continued folic acid supplementation throughout later gestation.
CLINICAL EPIGENETICS
(2022)
Article
Geriatrics & Gerontology
Adam H. Dyer, Eamon Laird, Leane Hoey, Catherine F. Hughes, Helene McNulty, Mary Ward, J. J. Strain, Maurice O'Kane, Fergal Tracey, Anne M. Molloy, Conal Cunningham, Donal J. Sexton, Kevin McCarroll
Summary: This study found that reduced kidney function in older adults is associated with poorer cognitive performance, especially in domain-specific areas. The strongest associations were observed in individuals with eGFR <45 ml/min/1.73 m(2) and those aged 60-70.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Martina Rooney, Catherine F. Hughes, J. J. Strain, Michelle Clements, Helene McNulty, Mary Ward
Summary: This study provides the first evidence that brachial and central blood pressure are significantly higher in adults with the variant MTHFR 677TT genotype, and this phenomenon is more pronounced in women.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Joshua Poole, Paniz Jasbi, Agnes S. Pascual, Sean North, Neha Kwatra, Volkmar Weissig, Haiwei Gu, Teodoro Bottiglieri, Nafisa M. Jadavji
Summary: Vitamin B12 deficiency is common in the elderly and has been associated with worse stroke outcomes. This study investigated the impact of vitamin B12 deficiency on stroke outcomes and mechanisms using aged female mice. The results showed that vitamin B12 deficiency impaired motor function after stroke, possibly through increased apoptosis and changes in mitochondrial metabolism in brain tissue.
Article
Endocrinology & Metabolism
Michelle Clements, Maria Heffernan, Mary Ward, Leane Hoey, Leanne C. Doherty, Roberta Hack Mendes, Michelle M. Clarke, Catherine F. Hughes, Ingrid Love, Shauna Murphy, Eilish McDermott, Jennifer Grehan, Adrian McCann, Liadhan B. McAnena, J. J. Strain, Lorraine Brennan, Helene McNulty
Summary: This study investigates the effect of low-dose B-vitamins on bone mineral density in adults aged >= 50 years. The results show that the intervention had no overall effect on BMD, but improving B-vitamin status appears to have specific benefits for bone health in adults with lower B12 status.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Nutrition & Dietetics
Ali Niklewicz, A. David Smith, Alison Smith, Andre Holzer, Andrew Klein, Andrew McCaddon, Anne M. Molloy, Bruce H. R. Wolffenbuttel, Ebba Nexo, Helene McNulty, Helga Refsum, Jean-Louis Gueant, Marie-Joe Dib, Mary Ward, Michelle Murphy, Ralph Green, Kourosh R. Ahmadi, Luciana Hannibal, Martin J. Warren, P. Julian Owen
Summary: Vitamin B-12 deficiency is common among vegetarians and vegans, especially pregnant women or women of child-bearing age. It is associated with increased risk of neuro, vascular, immune, and inflammatory disorders. However, the current recommended nutrient intake for vitamin B-12 does not adequately consider the needs of individuals choosing a plant-based diet.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Carles Lerin, Maria Carmen Collado, Elvira Isganaitis, Erland Arning, Brandi Wasek, Ellen W. Demerath, David A. Fields, Teodoro Bottiglieri
Summary: The concentration of S-adenosylmethionine (SAM) is higher in breast milk compared to other biofluids and is absent in infant milk formulas. This may suggest a strong demand for this metabolic nutrient during infant early growth.
Article
Neurosciences
Karel Kalecky, Teodoro Bottiglieri
Summary: We conducted metabolomic analysis in human brain cortex and putamen to identify metabolic changes associated with Parkinson's disease and PD-related cognitive decline. The study included 101 subjects and revealed changes in neurotransmitters, bile acids, homocysteine metabolism, and other pathways. Levodopa-related homocysteine accumulation in the cortex appears to be the main factor contributing to dementia in PD, which can potentially be improved through dietary supplementation. Further investigation is needed to understand the underlying mechanisms.
NPJ PARKINSONS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.