Journal
BEHAVIORAL AND BRAIN FUNCTIONS
Volume 16, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12993-020-00168-4
Keywords
Drug dependence; Withdrawal; Homeostatic plasticity; Synaptic scaling; Dopamine
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Funding
- Kungl Vetenskapssamh Scholarship (Royal Society of Arts and Scientists) by Uppsala University, Sweden
- Swedish Research Council
- Swedish Brain Research Foundation
- European Union [857394]
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Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine first exposure and posterior craving maintenance. However, the exact rules that coordinate the synaptic dynamics of these receptors in dopaminergic VTA neurons and behavioral outcomes are poorly understood. Additionally, synaptic homeostatic plasticity is present in response to chronic excitability changes in neuronal circuits, adjusting the strength of synapses to stabilize the firing rate. Despite having correspondent mechanisms, little is known about the relationship between continuous cocaine exposure and homeostatic synaptic changes in the VTA neurons. Here, we assess the role of homeostatic mechanisms in the neurobiology of cocaine addiction by providing a brief overview of the parallels between cocaine-induced synaptic potentiation and long-term synaptic adaptations, focusing on the regulation of GluA1- and GluN1- containing receptors.
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