Article
Multidisciplinary Sciences
Yeon Ui Lee, Shilong Li, G. Bimananda M. Wisna, Junxiang Zhao, Yuan Zeng, Andrea R. Tao, Zhaowei Liu
Summary: The authors demonstrate a label-free superresolution imaging method using a hyperbolic material for tailored light-matter interactions. By enhancing scattering and utilizing dark-field detection, the resolution is improved by 5.5 times beyond the diffraction limit. This method provides capabilities for super-resolution imaging where fluorescence is not available or challenging to apply.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Zhenqiang Ning, Erli Yang, Yongjun Zheng, Mengyuan Chen, Guoqiu Wu, Yuanjian Zhang, Yanfei Shen
Summary: This study proposed a facile synthesis strategy to prepare a self-enhanced ECL emitter DEAMTES@RuSiO2, which exhibited improved ECL properties and film-forming ability critical for ECL biosensors. By combining catalytic hairpin assembly and signal amplification, a label-free ECL biosensor was constructed for highly sensitive detection of miRNA-21 with a detection limit of 8.19 fM, showing superior reliability in detecting miRNA-21 in human serum samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Aleksandr Barulin, Prithu Roy, Jean-Benoit Claude, Jerome Wenger
Summary: The authors introduce optical horn antennas, a nanophotonic platform, for the label-free detection of UV autofluorescence from single proteins. This technique allows for real-time monitoring of protein unfolding and dissociation.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Analytical
Pengcheng Wang, Hao Sun, Wei Yang, Yimin Fang
Summary: This paper reviews the application of label-free optical methods for the rapid detection of pathogenic bacteria. These methods have advantages of rapidity, simplicity, and relatively low-cost, and can overcome the limitations of traditional detection techniques, promoting precise therapy initiation.
Article
Oncology
Ertug Avci, Hulya Yilmaz, Nurettin Sahiner, Bilge Guvenc Tuna, Munevver Burcu Cicekdal, Mehmet Eser, Kayhan Basak, Fatih Altintoprak, Ismail Zengin, Soner Dogan, Mustafa Culha
Summary: This study investigates the reliability of surface-enhanced Raman scattering (SERS) for cancer diagnosis by varying several parameters. The results demonstrate the potential of this technique to accurately differentiate blood samples from cancer patients, healthy individuals, and patients with chronic diseases.
Article
Engineering, Environmental
Yating Meng, Zhuqing Zhang, Hongxia Zhao, Yuan Jiao, Jun Li, Shaomin Shuang, Chuan Dong
Summary: This study demonstrates the preparation of multifunctional carbon dots with orange emission for bioimaging and monitoring of morin and hypochlorite in living cells and zebrafish, showing low toxicity and superior biocompatibility.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Eun Hye Koh, Won-Chul Lee, Yeong-Jin Choi, Joung-Il Moon, Jinah Jang, Sung-Gyu Park, Jaebum Choo, Dong-Ho Kim, Ho Sang Jung
Summary: A wearable SERS sensor has been developed for molecular sweat sensing, with the capability of measuring Raman signals without detachment from the skin. Through a multi-layer design, the sensor can absorb sweat, protect the skin, enhance signal, and has great potential for drug detection applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Physics, Multidisciplinary
Chenjun Shi, Hongyuan Zhang, Jitao Zhang
Summary: Brillouin microscopy based on spontaneous Brillouin scattering is a unique elastography technique for mechanical imaging of biological cell and tissue. Stimulated Brillouin-based methods have the potential to improve the speed and spectral resolution of existing Brillouin microscopy. This review discusses the ongoing technological advancements of three stimulated Brillouin-based methods and their applications in biophysics and mechanobiology.
FRONTIERS IN PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Igor Buzalewicz, Iwona Holowacz, Anna K. Matczuk, Mateusz Guzniczak, Dominika Skrzela, Magdalena Karwanska, Alina Wieliczko, Katarzyna Kowal, Agnieszka Ulatowska-Jarza
Summary: The worldwide increase in bacterial resistance and healthcare-associated bacterial infections pose a serious threat to human health. A new therapeutic approach based on the limited delivery of photosensitizer has been proposed, using nanoporous inorganic-organic composites encapsulating Photolon. The material exhibits excellent antimicrobial activity, and the generation of free radicals from the nanoporous surface has been confirmed by scanning Kelvin probe microscopy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jonatan Alvelid, Andrea Bucci, Ilaria Testa
Summary: This study introduces a multicolour STED nanoscopy technique using far red-shifted semiconductor CdTe quantum dots (QDs). By optimizing the STED imaging of QDs, blinking effects are minimized and the number of detected photons is maximized. This method enables straightforward three-colour STED imaging and can be applied to study the internalization of QDs in cells.
Article
Chemistry, Multidisciplinary
Nantao Li, Xiaojing Wang, Joseph Tibbs, Congnyu Che, Ana Sol Peinetti, Bin Zhao, Leyang Liu, Priyash Barya, Laura Cooper, Lijun Rong, Xing Wang, Yi Lu, Brian T. Cunningham
Summary: This study introduces a label-free biosensing method for quickly detecting and quantifying intact viruses in human saliva with high selectivity and sensitivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemical Research Methods
Christoffer Edlund, Timothy R. Jackson, Nabeel Khalid, Nicola Bevan, Timothy Dale, Andreas Dengel, Sheraz Ahmed, Johan Trygg, Rickard Sjoegren
Summary: The LIVECell dataset consists of annotated phase-contrast images of over 1.6 million cells, aiming to improve the training of image segmentation models through deep learning. Its creation and utilization help explore biological phenomena and conduct high-throughput quantitative imaging studies.
Article
Chemistry, Analytical
Xinyu Zhou, Rui Wang, Zijian Wan, Pengfei Zhang, Shaopeng Wang
Summary: In this study, we demonstrate multiplexed protein detection and parallel protein interaction analysis through evanescent scattering microscopy (ESM). ESM allows label-free digital single-molecule counting for binding kinetics measurement, improving counting efficiency and accuracy. We show that digital single-molecule counting can differentiate proteins with different molecular weights, enabling real-time monitoring of protein binding processes in solution. Additionally, we show that this strategy can analyze the kinetics of two different protein interaction processes simultaneously, both on surfaces and in solution. This work may provide a way to investigate complex protein interactions, such as the competition between biomarker-antibody binding in biofluids and biomarker-protein binding on cellular membranes.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Camila de Paula D'Almeida, Kamila Jessie Sammarro Silva, Lyda Patricia Sabogal-Paz, Sebastia Pratavieira
Summary: This study explores the potential of lens-free holographic microscopy (LHM) for the detection and counting of Giardia cysts. Compared to immunofluorescence assays (IFA), LHM offers a simpler and faster method for quantification, accurately counting cysts and showing potential for water quality assessment. However, limitations of LHM include the need to consider matrix effects and its lower sensitivity.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Xinyu Zhou, Rui Wang, Zijian Wan, Pengfei Zhang, Shaopeng Wang
Summary: Multiplexed protein detection and parallel protein interaction analysis are achieved using evanescent scattering microscopy (ESM), enabling label-free digital single-molecule counting with high temporal resolution. This strategy allows for real-time tracking of protein binding processes and simultaneous analysis of multiple protein interactions.
ANALYTICAL CHEMISTRY
(2023)
Article
Optics
S. Sempere-Llagostera, G. S. Thekkadath, R. B. Patel, W. S. Kolthammer, I. A. Walmsley
Summary: In this study, we use the photon-number resolving capabilities of commercial superconducting nanowire single-photon detectors to improve the quality of single photons generated through nonlinear processes. Our results demonstrate the feasibility of enhancing the quality of heralded single-photon sources using readily available technology.
Article
Physics, Multidisciplinary
G. S. Thekkadath, B. A. Bell, R. B. Patel, M. S. Kim, I. A. Walmsley
Summary: The article presents a scheme for measuring the time-frequency structure of quantum light and demonstrates its effectiveness through experiments. The proposed method does not require phase stability, nonlinearities, or spectral shaping, making it a simple and practical way to measure the modal structure of quantum light.
PHYSICAL REVIEW LETTERS
(2022)
Article
Multidisciplinary Sciences
Jacob F. F. Bulmer, Bryn A. Bell, Rachel S. Chadwick, Alex E. Jones, Diana Moise, Alessandro Rigazzi, Jan Thorbecke, Utz-Uwe Haus, Thomas Van Vaerenbergh, Raj B. Patel, Ian A. Walmsley, Anthony Laing
Summary: Identifying the boundary at which quantum machines provide a computational advantage over classical counterparts is crucial. Gaussian boson sampling (GBS), which involves measuring photons from a highly entangled Gaussian state, is a leading approach in pursuing quantum advantage. This paper presents faster classical GBS simulation methods and introduces an efficient distribution for classical sampling that passes various GBS validation methods.
Article
Optics
Bangshan Sun, Fyodor Morozko, Patrick S. Salter, Simon Moser, Zhikai Pong, Raj B. Patel, Ian A. Walmsley, Mohan Wang, Adir Hazan, Nicolas Barre, Alexander Jesacher, Julian Fells, Chao He, Aviad Katiyi, Zhen-Nan Tian, Alina Karabchevsky, Martin J. Booth
Summary: This paper reports a new method for femtosecond laser writing of optical-fiber-compatible glass waveguides, which enables high precision and low loss control of waveguide cross-sections. The fabricated waveguides show high refractive index contrast, low propagation loss, and low coupling loss, and they can operate across a broad range of wavelengths.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Physics, Multidisciplinary
S. Sempere-Llagostera, R. B. Patel, I. A. Walmsley, W. S. Kolthammer
Summary: Gaussian boson sampling is a concept in quantum computing that involves drawing samples from a nonclassical Gaussian state using photon-number resolving detectors. In this study, we experimentally implement Gaussian boson sampling using a time-bin encoded interferometer and find improvements in searching for dense subgraphs in a graph.
Article
Physics, Applied
S. E. Thomas, S. Sagona-Stophel, Z. Schofield, I. A. Walmsley, P. M. Ledingham
Summary: This paper reports a telecommunications wavelength- and bandwidth-compatible quantum memory, which enables efficient storage and on-demand retrieval of quantum optical states. It is an essential technology for future terrestrial-based quantum optical networking. The memory demonstrates a total internal efficiency of 20.90(1)% and a Doppler-limited storage time of 1.10(2) ns using the Off-Resonant Cascaded Absorption protocol in hot 87Rb vapor.
PHYSICAL REVIEW APPLIED
(2023)
Article
Multidisciplinary Sciences
F. H. B. Somhorst, R. van der Meer, M. Correa Anguita, R. Schadow, H. J. Snijders, M. de Goede, B. Kassenberg, P. Venderbosch, C. Taballione, J. P. Epping, H. H. van den Vlekkert, J. Timmerhuis, J. F. F. Bulmer, J. Lugani, I. A. Walmsley, P. W. H. Pinkse, J. Eisert, N. Walk, J. J. Renema
Summary: This study demonstrates that in a unitarily evolving system, single-mode measurements can converge to a thermal state using photons in an integrated optical interferometer. The resolution to the paradox between unitary evolution and the second law of thermodynamics is the recognition that the global unitary evolution of a multi-partite quantum state causes local subsystems to evolve towards maximum-entropy states. The experiment utilizes a programmable integrated quantum photonic processor to manipulate quantum states and shows the potential of photonic devices for simulating non-Gaussian states.
NATURE COMMUNICATIONS
(2023)
Proceedings Paper
Instruments & Instrumentation
Georg Enzian, Lars Freisem, John J. Price, Andreas O. Svela, Jack Clarke, Magdalena Szczykulska, Joshua Nunn, Ian Walmsley, Jonathan Silver, Leonardo Del Bino, Shuangyou Zhang, Pascal Del'Haye, Biveen Shajilal, Jiri Janousek, Ben C. Buchler, Ping Koy Lam, Michael R. Vanner
Summary: Research on backward Brillouin scattering in whispering-gallery-mode micro-resonators provides a promising avenue for both classical and quantum optomechanics applications. Our team, in collaboration with others, is utilizing this regime to prepare non-Gaussian motional states of the acoustic field. Recent experimental results include Brillouin optomechanical strong coupling, manipulation of thermal states by adding or subtracting single phonons, and phase-space tomography of non-Gaussian states generated by subtracting single or multiple phonons.
OPTICAL AND QUANTUM SENSING AND PRECISION METROLOGY II
(2022)
Article
Quantum Science & Technology
G. S. Thekkadath, S. Sempere-Llagostera, B. A. Bell, R. B. Patel, M. S. Kim, I. A. Walmsley
Summary: This paper presents a GBS machine that achieves displacement by injecting a laser beam and a two-mode squeezed vacuum state. The study shows that the machine has the ability to reconstruct multimode Gaussian state and reduce computational complexity.
Proceedings Paper
Engineering, Electrical & Electronic
Georg Enzian, John J. Price, Lars Freisem, Magdalena Szczykulska, Joshua Nunn, Ian A. Walmsley, Jonathan Silver, Leonardo Del Bino, Shuangyou Zhang, Pascal Del'Haye, Jiri Janousek, Ben C. Buchler, Ping Koy Lam, Michael R. Vanner
Summary: In this experiment, strong coupling between optical and acoustic fields was demonstrated, and single-phonon addition and subtraction operations were successfully performed.
2021 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2021)
