Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00993-20
Keywords
bacteriophages; bacteriophage-antibiotic combinations; daptomycin; Enterococcus faecium
Categories
Funding
- NIAID [R01 AI121400, R01 AI141479]
- NIH/NIAID [R01 AI134637, R21 AI143229, K24 AI121296]
- UTHealth Presidential Award
- University of Texas System STARS Award
- Ancillia Ltd.
- Merck
- MemEd Diagnostics
- Entasis Therapeutics
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Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium. After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities ere selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.
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