Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Francesco Ursini, Piero Ruscitti, Olga Addimanda, Rosario Foti, Vincenzo Raimondo, Giuseppe Murdaca, Virginia Caira, Erika Pigatto, Giovanna Cuomo, Alberto Lo Gullo, Ilaria Cavazzana, Corrado Campochiaro, Caterina Naclerio, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Elena Marchetti, Francesca Motta, Marcella Visentini, Sebastiano Lorusso, Maria De Santis, Giacomo De Luca, Laura Massaro, Domenico Olivo, Roberta Pellegrini, Francesca Francioso, Jessica Luppino, Ilenia Di Cola, Roberta Foti, Giuseppe Varcasia, Francesco Caso, Massimo Reta, Lorenzo Dagna, Carlo Selmi, Annamaria Iagnocco, Roberto Giacomelli, Florenzo Iannone, Clodoveo Ferri
Summary: The study aims to define the spectrum of new-onset inflammatory rheumatic diseases (IRD) after COVID-19 and COVID-19 vaccine. The results show a broad range of possible clinical manifestations, including inflammatory joint diseases, polymyalgia rheumatica, connective tissue diseases, and vasculitis.
Article
Rheumatology
Victoria Furer, Christien Rondaan, Nancy Agmon-Levin, Sander van Assen, Marc Bijl, Meliha Crnkic Kapetanovic, Annette de Thurah, Ulf Mueller-Ladner, Daphna Paran, Karen Schreiber, Klaus Warnatz, Nico M. Wulffraat, Ori Elkayam
Summary: This paper reviews the current data on COVID-19 infection in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and discusses the efficacy and safety of vaccination against COVID-19 in this population. It proposes preliminary considerations for vaccination based on expert opinion and knowledge of vaccination in AIIRD patients.
Review
Immunology
Pamir Ataguenduez, Goekhan Keser, Mehmet Soy
Summary: New variants of SARS-CoV-2 have raised concerns about the spread of COVID-19, particularly among patients with autoimmune/autoinflammatory rheumatic diseases (AIIRD). The timing of COVID-19 vaccination in AIIRD patients using Interleukin-1 (IL-1) blockers is still a topic of debate.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Jiali Chen, Fen Li, Jing Tian, Xi Xie, Qi Tang, Yiyue Chen, Yan Ge
Summary: This study investigated the adverse events, specifically varicella-zoster virus (VZV) reactivation, following vaccination against severe acute respiratory syndrome coronavirus-2 in a Chinese cohort of autoimmune inflammatory rheumatic diseases (AIIRDs) patients. The findings showed that the inactivated COVID-19 vaccination was safe for AIIRD patients, although some patients could experience VZV reactivation.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Rheumatology
Javier Bachiller-Corral, Alina Boteanu, Maria Jesus Garcia-Villanueva, Carlos de la Puente, Marcelino Revenga, M. Consuelo Diaz-Miguel, Ana Rodriguez-Garcia, Jose Luis Morell-Hita, Marta Valero, Carmen Larena, Maria Blazquez-Canamero, Carlos A. Guillen-Astete, Sandra Garrote, Cristina Sobrino, Carmen Medina-Quinones, Monica Vazquez-Diaz
Summary: The study found that patients with inflammatory rheumatic diseases accounted for 1.8% of the total hospitalized population. Patients with diseases such as rheumatoid arthritis, vasculitis, and systemic lupus erythematosus had a higher risk of hospitalization. Rheumatoid arthritis patients also showed a higher mortality rate in COVID-19, especially those treated with RTX.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Bente Glintborg, Dorte Vendelbo Jensen, Lene Terslev, Oliver Hendricks, Mikkel Ostergaard, Simon Horskjaer Rasmussen, Mogens Pfeiffer Jensen, Thomas Adelsten, Ada Colic, Kamilla Danebod, Malene Kildemand, Anne Gitte Loft, Heidi Lausten Munk, Jens Kristian Pedersen, Rene Drage Ostgard, Christian Moller Sorensen, Niels Steen Krogh, Jette Norgaard Agerbo, Connie Ziegler, Merete Lund Hetland
Summary: A survey conducted on patients with inflammatory rheumatic disease (IRD) showed that levels of anxiety and self-isolation decreased after the initial lockdown period of the COVID-19 pandemic. However, in May 2021, half of the patients reported self-isolation, a phase that included the widespread reopening of society and large-scale vaccination.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Charalampos Papagoras, George E. Fragoulis, Nikoleta Zioga, Theodora Simopoulou, Kleopatra Deftereou, Eleni Kalavri, Evangelia Zampeli, Nafsika Gerolymatou, Evangelia Kataxaki, Konstantinos Melissaropoulos, Stylianos Panopoulos, Kalliopi Fragiadaki, Gerasimos Evangelatos, Vasiliki-Kalliopi Bournia, Aikaterini Arida, Anastasios Karamanakos, Maria Pappa, Alexandros Panagiotopoulos, Christos Koutsianas, Georgia Mparouta, Theodoros Dimitroulas, Stamatis-Nick Liossis, Maria G. Tektonidou, Evrydiki Kravvariti, Nikolaos Kougkas, Panagiotis Georgiou, Paraskevi Voulgari, Antonia Elezoglou, Dimitrios P. Bogdanos, Dimitrios Vassilopoulos, Petros P. Sfikakis
Summary: Vaccinated patients with systemic rheumatic diseases who experience breakthrough COVID-19 have better outcomes compared to unvaccinated patients with similar disease characteristics. This highlights the importance of COVID-19 vaccination in vulnerable populations like those with SRDs.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Benjamin Fernandez-Gutierrez, Leticia Leon, Alfredo Madrid, Luis Rodriguez-Rodriguez, Dalifer Freites, Judit Font, Arkaitz Mucientes, Esther Culebras, Jose Ignacio Colome, Juan Angel Jover, Lydia Abasolo
Summary: In patients with IRD, older age, male gender, comorbidities, and specific systemic autoimmune conditions (Sjogren, polychondritis, Raynaud, and mixed connective tissue disease) were associated with a higher risk of hospital admissions related to COVID-19. Exposure to ts/bDMARDs did not reach statistical significance in influencing the risk of hospital admission.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Article
Rheumatology
Amanthi Nadira Arumahandi de Silva, Leonie Maria Frommert, Fredrik N. Albach, Jens Klotsche, Veronika Scholz, Lara Maria Jeworowski, Tatjana Schwarz, Alexander ten Hagen, Jan Zernicke, Victor Max Corman, Christian Drosten, Gerd-Ruediger Burmester, Robert Biesen
Summary: This study found that methotrexate (MTX) reduces the humoral immune response to COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD), and discontinuing MTX for at least 10 days significantly improves antibody response in patients over 60 years old.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Amir Bieber, Iftach Sagy, Lena Novack, Shay Brikman, Ran Abuhasira, Snait Ayalon, Irina Novofastovski, Mahmoud Abu-Shakra, Reuven Mader
Summary: This study used data from Clalit Health Services, which covers more than half of the population in Israel, to investigate the association between COVID-19 vaccination and outcomes in patients with autoimmune rheumatic diseases (ARD). The results showed that both the BNT162b2 mRNA COVID-19 vaccine and the booster dose were associated with better COVID-19 outcomes in patients with ARD.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Marc H. A. Jansen, Christien Rondaan, Geertje E. Legger, Kirsten Minden, Yosef Uziel, Natasa Toplak, Despoina Maritsi, Lotte van den Berg, Guy A. M. Berbers, Patricia Bruijning, Yona Egert, Christophe Normand, Marc Bijl, Helen E. Foster, Isabelle Kone-Paut, Carine Wouters, Angelo Ravelli, Ori Elkayam, Nicolaas M. Wulffraat, Marloes W. Heijstek
Summary: This article updates the EULAR recommendations on vaccination for pedAIIRD patients, providing guidelines on vaccination principles, special circumstances, and the safety for immunosuppressed patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
George E. Fragoulis, Elena Nikiphorou, Mrinalini Dey, Sizheng Steven Zhao, Delphine Sophie Courvoisier, Laurent Arnaud, Fabiola Atzeni, Georg M. N. Behrens, Johannes W. J. Bijlsma, Peter Boehm, Costas A. Constantinou, Silvia Garcia-Diaz, Meliha Crnkic Kapetanovic, Kim Lauper, Mariana Luis, Jacques Morel, Gyoergy Nagy, Eva Poleverino, Jef van Rompay, Marco Sebastiani, Anja Strangfeld, Annette de Thurah, James Galloway, Kimme L. Hyrich
Summary: This study aims to develop recommendations for screening and prevention of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Four overarching principles and eight specific recommendations were formulated through international collaboration. These recommendations provide guidance for clinical practice to reduce the burden of opportunistic infections in AIIRD patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Irene Altabas-Gonzalez, Inigo Rua-Figueroa, Francisco Rubino, Coral Mourino Rodriguez, Inigo Hernandez-Rodriguez, Raul Menor Almagro, Esther Uriarte Isacelaya, Eva Tomero Muriel, Tarek C. Salman-Monte, Irene Carrion-Barbera, Maria Galindo, Esther M. Rodriguez Almaraz, Norman Jimenez, Luis Ines, Jose Maria Pego-Reigosa
Summary: This study applied the LLDAS criteria to a large patient cohort and assessed its agreement with the physician's evaluation of lupus activity. The study found a fair correlation between the LLDAS and physician assessment, with better agreement for patients fulfilling the LLDAS criteria.
Article
Orthopedics
W. Wirth, S. Maschek, A. C. A. Marijnissen, A. Lalande, F. J. Blanco, F. Berenbaum, L. A. van de Stadt, M. Kloppenburg, I. K. Haugen, C. H. Ladel, J. Bacardit, A. Wisser, F. Eckstein, F. W. Roemer, F. P. J. G. Lafeber, H. H. Weinans, M. Jansen
Summary: The study aims to investigate the test-retest precision of cartilage thickness and report longitudinal changes in the IMI-APPROACH cohort. The machine-learning-estimated structural progression score (s-score) was not predictive of cartilage thickness loss.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Andrew Ostor, Filip van den Bosch, Kim Papp, Cecilia Asnal, Ricardo Blanco, Jacob Aelion, Wenjing Lu, Zailong Wang, Ahmed M. Soliman, Ann Eldred, Byron Padilla, Alan Kivitz
Summary: This study evaluated the efficacy and safety of risankizumab 150 mg in patients with active PsA for 52 weeks. The results showed that risankizumab was effective in improving symptoms and had a good safety profile.
Article
Rheumatology
Sabrina V. Porta, Danieli Castro Oliveira de Andrade, Doruk Erkan, Jose A. Gomez-Puerta, Luis J. Jara, Paula Alba Moreyra, Guillermo J. Pons-Estel
Summary: Strategies to prevent thrombosis in aPL-positive patients are crucial, and the risk varies depending on additional factors. Recurrent thrombosis is common despite treatment, and the effectiveness of new oral anticoagulants and low-dose aspirin is debated. There is an urgent need to identify patients who may benefit from aspirin use. This article provides a useful discussion to aid treatment decision-making in clinical practice.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Immunology
Marc Xipell, Gema M. Lledo, Allyson C. Egan, Farah Tamirou, Cristina Serrano del Castillo, Jordi Rovira, Jose A. Gomez-Puerta, Adriana Garcia-Herrera, Ricard Cervera, Andreas Kronbichler, David R. W. Jayne, Hans-Joachim Anders, Frederic Houssiau, Gerard Espinosa, Luis F. Quintana
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance against nuclear and cytoplasmic self-antigens, induction of immunity, and tissue inflammation. Lupus nephritis (LN) is a common complication of SLE, affecting around 30% of patients at disease onset and up to 50-60% within the first 10 years. This review focuses on the pathogenic mechanisms of SLE, the immunological pathways of kidney damage in LN, and the rationale for the treatment of LN.
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
J. Tandaipan, A. Guillen-Del-Castillo, C. P. Simeon-Aznar, P. E. Carreira, C. De la Puente, J. Narvaez, J. Lluch, M. Rubio-Rivas, J. J. Alegre-Sancho, G. Bonilla, C. Moriano, I. Casafont-Sole, R. Garcia-Vicuna, V. Ortiz-Santamaria, E. Riera, B. Atienza-Mateo, R. Blanco, C. Galisteo, J. J. Gonzalez-Martin, J. M. Pego-Reigosa, A. Pros, S. Heredia, I. Castellvi
Summary: This study suggests that IVIG may improve myositis, gastrointestinal, and skin involvement in SSc patients treated in routine care and seems to have a good safety profile.
AUTOIMMUNITY REVIEWS
(2023)
Article
Medicine, General & Internal
Fabricio Benavides-Villanueva, Javier Loricera, Vanesa Calvo-Rio, Cristina Corrales-Selaya, Santos Castaneda, Ricardo Blanco
Summary: The aim of this study was to assess the effectiveness and safety of intravenous immunoglobulins (IVIG) in the treatment of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). The results showed that IVIG is an effective and relatively safe therapeutic option for patients with relapsing/refractory AAV or concomitant active infection.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zeina Ibrahim-Achi, Pablo Jorge-Perez, Pedro Abreu-Gonzalez, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by vasculopathy, progressive fibrosis, and systemic inflammation. This study found that serum malondialdehyde (MDA) levels were associated with higher levels of total and LDL cholesterol, as well as a lower left ventricular ejection fraction in patients with SSc. MDA may serve as a potential biomarker for dyslipidemia and heart failure in SSc.
Article
Medicine, General & Internal
Marta Gonzalez-Sierra, Alejandro Romo-Cordero, Juan Carlos Quevedo-Abeledo, Adrian Quevedo-Rodriguez, Fuensanta Gomez-Bernal, Antonia de Vera-Gonzalez, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between mean platelet volume (MPV) and disease activity in patients with rheumatoid arthritis (RA). The results showed that RA patients had lower levels of MPV compared to controls, and MPV was negatively correlated with inflammatory markers and disease activity, but not cardiovascular risk factors or subclinical atherosclerosis.
Article
Cell & Tissue Engineering
M. Pineiro-Ramil, C. Sanjurjo-Rodriguez, S. Rodriguez-Fernandez, T. Hermida-Gomez, F. J. Blanco-Garcia, I. Fuentes-Boquete, C. Vaamonde-Garcia, S. Diaz-Prado
Summary: The aim of this study was to develop immortalized chondrocyte cell lines from articular cartilage of patients with and without osteoarthritis (OA). By transducing primary articular chondrocytes with telomerase reverse transcriptase (hTERT) and SV40 large T antigen (SV40LT), the researchers successfully immortalized the chondrocytes. Although these cell lines were unable to synthesize cartilage-like tissue under the experimental conditions, they retained the ability to respond to IL-113 cytokine, making them advantageous for OA investigation.
BONE & JOINT RESEARCH
(2023)
Article
Medicine, Research & Experimental
E. Rodriguez-Almaraz, E. Gutierrez-Solis, E. Rabadan, P. Rodriguez, M. Alonso, L. Carmona, M. J. Garcia de Yebenes, E. Morales, M. Galindo-Izquierdo
Summary: This study aimed to evaluate the development of a prognostic index for lupus nephritis (LN), using clinical, analytical, and histological factors to determine which patients would have a worse disease progression and require more aggressive treatment and closer follow-up within 6 months after diagnosis of LN.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Rheumatology
G. Suarez-Amorin, R. Demetrio-Pablo, R. Fernandez-Ramon, A. Herrero-Morant, C. Alvarez-Reguera, L. Sanchez-Bilbao, D. Martinez-Lopez, J. L. Martin-Varillas, S. Castaneda, M. A. Gonzalez-Gay, R. Blanco
Summary: This study assessed the epidemiology and clinical manifestations of Behcet's disease (BD) in a population-based cohort in Northern Spain, finding that the prevalence of BD in Cantabria is higher than in other Southern European countries, and the clinical phenotypes observed are similar to those described in other regions.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Marta Carrillo-Palau, Belen Vera-Santana, Andrea Morant-Dominguez, Alejandro Hernandez-Camba, Laura Ramos, Inmaculada Alonso-Abreu, Noemi Hernandez Alvarez-Buylla, Laura Arranz, Milagros Vela, Manuel Hernandez-Guerra, Cristina Gomez-Moreno, Miguel a. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are higher in inflammatory bowel disease (IBD) patients, but the systemic immune-inflammatory index (SIRI) and monocyte-to-lymphocyte ratio (MLR) are not significantly different. None of these hematological scores are related to disease activity in IBD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elena Heras-Recuero, Marta Martinez de Bourio-Allona, Laura Cristina Landaeta-Kancev, Teresa Blazquez-Sanchez, Arantxa Torres-Rosello, Miguel Alvarez-Rubio, Mariam Belhaj-Gandar, Juan Antonio Martinez-Lopez, Luis Martinez-Dhier, Javier Llorca, Raquel Largo, Miguel Angel Gonzalez-Gay
Summary: This study found that significant extravascular FDG uptake can help establish a clinical diagnosis of PMR in patients with LV-GCA. Patients are more likely to be diagnosed with PMR if they have significant FDG uptake in the shoulder, greater trochanter, and lumbar interspinous areas.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Lorena Rodriguez-Martinez, Cristina Garcia-Moreno, Eva Perez-Pampin, Maria J. Gomara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golan, Jose A. Gomez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmarti, Isabel Haro, Antonio Gonzalez
Summary: Autoantibodies play a critical role in the pathogenesis and clinical assessment of rheumatoid arthritis. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies have been claimed to have high sensitivity for all rheumatoid arthritis patients. However, the sensitivity of anti-MAA antibodies varies significantly between patient collections and is determined by complex factors including ethnicity, smoking, and sex.
ARTHRITIS RESEARCH & THERAPY
(2023)