Journal
ANNALS OF PLASTIC SURGERY
Volume 86, Issue 1, Pages 103-108Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SAP.0000000000002408
Keywords
peripheral nerve repair; nerve reconstruction; nerve graft; neurorrhaphy; fibrin glue; cyanoacrylates; laser nerve welding; suture; sutureless
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Funding
- Axogen
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Although peripheral nerve repair remains a challenge, fibrin glue has shown promise as an effective adhesive compound in improving outcomes of nerve reconstruction. Its ability to reduce inflammation, enhance axonal regeneration, and provide excellent functional results make it a potential alternative to traditional suture neurorrhaphy.
Over the past century, many advancements have been made in peripheral nerve repair, yet these reconstructions still remain a challenge. Although sutures have historically been used for neurorrhaphy, they sometimes fail to provide optimal outcomes. As a result, multiple adhesive compounds are currently being investigated for their efficacy in nerve repair. Recently, fibrin glue has shown utility in peripheral nerve repair, and the body of evidence supporting its use continues to grow. Fibrin glue has been shown to reduce inflammation, improve axonal regeneration, and provide excellent functional results. This alternative to traditional suture neurorrhaphy could potentially improve outcomes of peripheral nerve reconstruction.
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