Journal
ANNALS OF NEUROLOGY
Volume 88, Issue 4, Pages 851-854Publisher
WILEY
DOI: 10.1002/ana.25838
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Funding
- James S. McDonnell Foundation COVID-19 Recovery of Consciousness Consortium
- NIH National Institute of Neurological Disorders and Stroke [R21NS109627, R25NS06574309, K23NS094538, RF1NS115268]
- NIH Director's Office [DP2HD101400]
- NIH National Institute on Aging [R21AG067562]
- Tiny Blue Dot Foundation
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Many patients with severe coronavirus disease 2019 (COVID-19) remain unresponsive after surviving critical illness. Although several structural brain abnormalities have been described, their impact on brain function and implications for prognosis are unknown. Functional neuroimaging, which has prognostic significance, has yet to be explored in this population. Here we describe a patient with severe COVID-19 who, despite prolonged unresponsiveness and structural brain abnormalities, demonstrated intact functional network connectivity, and weeks later recovered the ability to follow commands. When prognosticating for survivors of severe COVID-19, clinicians should consider that brain networks may remain functionally intact despite structural injury and prolonged unresponsiveness. ANN NEUROL 2020
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