Progress in Total Syntheses of Leuconolam-Leuconoxine-Mersicarpine Alkaloids

Leuconolam-leuconoxine-mersicarpine monoterpene indole alkaloids are mainly isolated from Apocynaceae Kopsia species of plant. Though sharing the same biogenetic origin, they are a family of natural products showing incredible structural complexity and diversity. Moreover, many of them exhibit excellent bioactivities, for example, anti-inflammatory, anti-tumor activities. The progress in the total synthesis of this remarkable family of alkaloids is reviewed.