Article
Surgery
Jose Luis Campo-Canaveral de la Cruz, Eduardo Minambres, Elisabeth Coll, Maria Padilla, Gloria Sanchez Antolin, Gloria de la Rosa, Joel Rosado, Francisco Javier Gonzalez Garcia, Silvana Crowley Carrasco, Gabriel Sales Badia, Eva Maria Fieria Costa, Jose Alberto Garcia Salcedo, Victor Mora, Carlos de la Torre, Rafael Badenes, Lander Atutxa Bizkarguenaga, Beatriz Dominguez-Gil
Summary: This study aimed to investigate the outcomes of lung and liver transplantation using NRP in cDCD donors and compare them with transplants using DBD grafts. The results showed that simultaneous transplantation of lungs and livers from cDCD donors using NRP offers similar outcomes to transplants using DBD grafts.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
S. Dhanani, L. Hornby, A. van Beinum, N. B. Scales, M. Hogue, A. Baker, S. Beed, J. G. Boyd, J. A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C. J. Doig, F. Duska, J. O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. Isac, A. H. Kramer, D. J. Kutsogiannis, D. M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W. N. K. A. van Mook, P. Waldauf, M. Weiss, J. T. Wind, S. D. Shemie
Summary: This study investigated the timing of resumption of cardiac activity in patients after planned withdrawal of life-sustaining measures. It found that 14% of patients experienced transient resumption of cardiac activity after pulselessness, with only 1% of resumptions being identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Surgery
Suk Kyun Hong, Sunho Choe, Nam-Joon Yi, Aesun Shin, Eun Kyung Choe, Kyung Chul Yoon, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study evaluated the long-term mortality of Korean live liver donors by comparing it with the mortality of the general population, finding that liver donors have slightly higher long-term mortality rates. The most common causes of death were suicide, cancer, and traffic accidents.
Article
Surgery
Dwight D. Harris, Aaron Fleishman, Martha Pavlakis, Martin R. Pollak, Prabhakar K. Baliga, Vinayak Rohan, Liise K. Kayler, James R. Rodrigue
Summary: This study investigated the attitudes of African Americans towards ApoL1 testing. The results showed that most participants believed transplant programs should offer ApoL1 testing and supported potential kidney donors having the autonomy to make donation decisions or participate in shared decision-making. Furthermore, the majority of transplant candidates expressed reluctance to accept kidneys from individuals with the high-risk genotype.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Urology & Nephrology
Argiris Asderakis, Tarique K. Sabah, William J. Watkins, Usman Khalid, Laszlo Szabo, Michael R. Stephens, Sian Griffin, Rafael Chavez
Summary: This study evaluated the effects of different induction immunosuppression agents on the outcome of kidney transplants from donors after circulatory death (DCD). The results suggest that thymoglobulin induction may provide better patient survival compared to alemtuzumab, while having similar advantage in terms of acute rejection.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Gastroenterology & Hepatology
Bashar Aqel, Karn Wijarnpreecha, Surakit Pungpapong, C. Burcin Taner, Kunam Reddy, Michael Leise, Lanyu Mi, Rolland C. Dickson
Summary: Transplanting liver grafts from HCV-seropositive donors into HCV-seronegative recipients resulted in excellent short-term outcomes, with all patients achieving cure through effective and well tolerated antiviral therapy. Further long-term follow-up in clinical trials is needed for confirmation.
JOURNAL OF HEPATOLOGY
(2021)
Article
Surgery
Anji Wall, Matthew Rosenzweig, Gregory J. McKenna, Tsung-Wei Ma, Sumeet K. Asrani, Giuliano Testa
Summary: Super-rapid recovery (SRR) is the standard US practice for donation after circulatory death (DCD) abdominal organ procurement. However, a newer approach called thoracoabdominal normothermic regional perfusion (TA-NRP) shows promise for better recipient outcomes. In this study, TA-NRP kidney recipients had significantly lower rates of delayed graft function (DGF) compared to SRR kidney recipients. No biliary complications were observed in either group of liver recipients. These early results suggest that TA-NRP is an effective approach to expand the use of DCD organs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Shivank Madan, Omar Saeed, Stephen J. Forest, Daniel J. Goldstein, Ulrich P. Jorde, Snehal R. Patel
Summary: This study provides a preliminary analysis of adult donation after circulatory death heart transplantations (DCD-HTs) in the United States, showing favorable early outcomes and suggesting the potential for a substantial increase in adult heart transplant volumes with the use of DCD donors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Surgery
Chris J. Callaghan, Maria Ibrahim, Claire Counter, John Casey, Peter J. Friend, Christopher J. E. Watson, Nikolaos Karydis
Summary: An analysis of simultaneous pancreas-kidney (SPK) transplants from 2005 to 2018 in the UK found no statistically significant differences in 5-year pancreas graft survival between transplants from donation after circulatory death (DCD) and donation after brain death (DBD) donors. The study supports the increased use of SPK transplants from DCD donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Vincenza Colucci, Pasquale Gallo, Simona Simone, Luigi Morrone, Carlo Maria Alfieri, Loreto Gesualdo, Giuseppe Castellano
Summary: Living kidney donation can have an impact on the renal and cardiovascular outcomes of the donors. The age of the donor does not significantly affect the decline in renal function or the occurrence of major cardiovascular events. It is important to provide careful and timely follow-up for donors to prevent complications post-donation.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Eric A. Engels, Gary E. Fraser, Bertram L. Kasiske, Jon J. Snyder, Jason Utt, Charles F. Lynch, Jie Li, Karen S. Pawlish, Sandra Brown, Kelly J. Yu, Ruth M. Pfeiffer
Summary: This study used linked transplant and cancer registry data to investigate the cancer risk in living kidney donors. The findings suggest that, overall, kidney donors have a lower risk of cancer compared to the general population. However, there is an increased incidence of colorectal cancer and kidney cancer in kidney donors starting 7 years after donation, possibly due to adverse processes in the remaining kidney.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Nasrin El-Bandar, Markus H. Lerchbaumer, Robert Peters, Andreas Maxeiner, Katja Kotsch, Arne Sattler, Kurt Miller, Thorsten Schlomm, Bernd Hamm, Klemens Budde, Lutz Liefeldt, Thomas Fischer, Frank Friedersdorff
Summary: This study aimed to investigate the association between contrast-enhanced ultrasound (CEUS) findings and kidney function. CEUS examinations were conducted on 30 living kidney donors, and various perfusion parameters were analyzed. The results showed that mean signal intensity (MeanLin) had a significant correlation with kidney function, especially in normal-weight individuals. These findings suggest that CEUS signal intensity may be influenced by body mass index (BMI).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Pedro Ventura-Aguiar, Joana Ferrer, David Paredes, Camino Rodriguez-Villar, Angel Ruiz, Josep Fuster, Constantino Fondevila, Juan Carlos Garcia-Valdecasas, Enric Esmatjes, Ramon Adalia, Federico Oppenheimer, Josep M. Campistol, Fritz Diekmann, Maria J. Ricart
Summary: The study found that the cardiac arrest time in donors after brain death does not have a significant impact on pancreas transplant outcomes, but patients with longer CAT may need to postpone donation for a more comprehensive evaluation.
Article
Surgery
Takayuki Yamamoto, Srilakshmi Atthota, Divyansh Agarwal, Kerry Crisalli, Malcolm Macconmara, Tsukasa Nakamura, Richard Teo, Leigh Anne Dageforde, Shoko Kimura, Nahel Elias, Heidi Yeh, Adel Bozorgzadeh, Tatsuo Kawai, James F. Markmann
Summary: This study compares the outcomes of liver allografts preserved using portable normothermic machine perfusion (NMP) and ischemic cold storage (ICS) in liver transplantation procedures. It concludes that NMP can significantly reduce the incidence of early allograft dysfunction, reperfusion syndrome, and ischemic cholangiopathy after donation after circulatory death (DCD) liver transplantation.
Article
Critical Care Medicine
Jean-Herle Raphalen, Tal Soumagnac, Stephane Blanot, Wulfran Bougouin, Alexandre Bourdiault, Damien Vimpere, Hatem Ammar, Christelle Dagron, Kim An, Akshay Mungur, Pierre Carli, Alice Hutin, Lionel Lamhaut
Summary: This study found that organ transplantation from patients treated with ECPR after refractory OHCA showed one-year kidney graft survival rates comparable to those of patients not treated with ECPR.
Article
Surgery
Lynn D. Cornell, Hatem Amer, Jason K. Viehman, Ramila A. Mehta, John C. Lieske, Elizabeth C. Lorenz, Julie K. Heimbach, Mark D. Stegall, Dawn S. Milliner
Summary: Primary hyperoxaluria can lead to recurrent calcium oxalate deposits in kidney transplants, with higher levels of plasma and urine oxalate associated with increased risk of recurrence. Avoiding high plasma oxalate and reducing CaOx crystallization may help decrease the risk of recurrent oxalate nephropathy in patients with PH following kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Nattawat Klomjit, Mireille El Ters, Benjamin A. Adam, Priya Sampathkumar, Raymund R. Razonable, Sandra J. Taler, Timucin Taner, Mariam Priya Alexander
Summary: Neutralizing monoclonal antibodies like bamlanivimab show promise in treating COVID-19 in kidney transplant recipients, but their impact on kidney allograft histology is unclear. A case study reported diffuse peritubular capillary C4d staining following bamlanivimab treatment in a kidney transplant recipient with stable kidney function at 6 months post-biopsy.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Kristopher P. Croome, Amit K. Mathur, Bashar Aqel, Liu Yang, Timucin Taner, Julie K. Heimbach, Charles B. Rosen, Ricardo Paz-Fumagalli, C. Burcin Taner
Summary: This study provides a detailed analysis of the natural history and clinical course of IC, showing that IC can be classified into 4 distinct patterns with different clinical courses.
Editorial Material
Gastroenterology & Hepatology
Michael J. Levy, Emily C. Bendel, Haraldur Bjarnason, Christopher J. Reisenauer, Hatem Amer, Don C. Codipilly, Patrick G. Dean, Ferga C. Gleeson, Julie K. Heimbach, Manju Kalra, Mikel Prieto, Mark D. Stegall, Timucin Taner, Patrick S. Kamath
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Daniel S. Ramon, Danielle M. Troop, Theresa N. Kinard, Caroline C. Jadlowiec, Margaret S. Ryan, Winston R. Hewitt, Linda G. Olsen, Andres Jaramillo, Timucin Taner, Raymond L. Heilman
Summary: Simultaneous liver-kidney transplant (SLKT) with donor-specific antibodies (DSA) is common, but after a second liver transplant, an abrupt increase in DSA levels against the kidney led to antibody-mediated rejection (AMR). The clearance of antibodies depended on the HLA antigens expressed by the transplanted liver cells.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Alyson N. Fox, AnnMarie Liapakis, Ramesh Batra, Therese Bittermann, Juliet Emamaullee, Sukru Emre, Yuri Genyk, Hyosun Han, Whitney Jackson, Elizabeth Pomfret, Muhammad Raza, Manuel Rodriguez-Davalos, Susan Rubman Gold, Benjamin Samstein, Akhil Shenoy, Timucin Taner, John P. Roberts
Summary: This article reviews the increasing interest in anonymous nondirected living organ donation in the United States, discusses current transplant policy and emerging data in living donor liver transplantation, and aims to provide consensus guidance for safe evaluation and selection of nondirected living liver donors and just allocation of grafts.
Editorial Material
Gastroenterology & Hepatology
Randi J. Ryan, Timucin Taner, Julie K. Heimbach
LIVER TRANSPLANTATION
(2022)
Article
Respiratory System
Catarina Aragon Pinto, Vivek Iyer, Yahya A. Almodallal, Hasan Albitar, Hilary Dubrock, Hector Cajigas, Julie K. Heimbach, Charles B. Rosen, Kimberly Watt, Timucin Taner, Scott Nyberg, Hugo Vargas, Rodrigo Cartin-Ceba, Andrew P. Keaveny, Michael Krowka, Alice Gallo de Moraes
Summary: This study retrospectively analyzed hospital and intensive care unit outcomes in patients with hepatopulmonary syndrome (HPS) following liver transplantation. The results showed that most HPS patients had short durations of invasive mechanical ventilation, ICU stay, and hospital stay post-transplant, and the severity of HPS did not impact hospital mortality.
Editorial Material
Surgery
Juliet Emamaullee, Julie K. Heimbach, Kim M. Olthoff, Elizabeth A. Pomfret, John P. Roberts, Nazia Selzner
Summary: Living donor liver transplantation has increased in North America in recent years. However, there is a lack of granular data on long-term outcomes and safety for healthy living liver donors. Two recent studies using Korean registry data reported similar results but were presented differently, with one study having methodological limitations. The North American Living Liver Donor Innovation Group emphasizes the importance of scientific integrity when using transplant registry data and discusses the potential impact of these studies on living liver donation in North America.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Xiomara Benavides, Richard T. Rogers, Ek Khoon Tan, Massini A. Merzkani, Sorkko Thirunavukkarasu, Furkan Yigitbilek, Byron H. Smith, Andrew D. Rule, Aleksandra Kukla, George K. Chow, Julie K. Heimbach, Timucin Taner, Patrick G. Dean, Mikel Prieto, Mark D. Stegall
Summary: Most major complications of HALLDN occur after discharge, suggesting the need for close follow-up and indicating that the current literature may underestimate the true incidence.
MAYO CLINIC PROCEEDINGS
(2022)
Editorial Material
Immunology
Julie K. Heimbach, Timucin Taner
Article
Urology & Nephrology
Naba Farooqui, Mark Zaidi, Lisa Vaughan, Trevor D. McKee, Eram Ahsan, Kevin D. Pavelko, Jose C. Villasboas, Svetomir Markovic, Timucin Taner, Nelson Leung, Haidong Dong, Mariam P. Alexander, Sandra M. Herrmann
Summary: This study found that immune checkpoint inhibitors (ICIs) therapy may lead to acute kidney injury (AKI) and there are no biomarkers currently available to distinguish AKI caused by ICIs from other causes. The urine levels of cytokines such as TNF-a, IL-2, and IL-10 were significantly higher in AKI-ICI patients. Therefore, these T-cell responses and their respective cytokines may be helpful in differentiating AKI-ICI from AKI-other.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Gastroenterology & Hepatology
Puneeta Tandon, Alberto Zanetto, Salvatore Piano, Julie K. Heimbach, Srinivasan Dasarathy
Summary: Frailty is a decline in functional reserve across multiple physiological systems, with key components being sarcopenia and physical frailty. These conditions are common in liver transplant candidates and have been shown to adversely impact clinical outcomes. The liver frailty index and cross-sectional image analysis of muscle area are used to assess physical frailty and sarcopenia, respectively. Nutritional interventions and physical activity are important management strategies, but there is a need for more large-scale trials. It is also recognized that a multidisciplinary approach is necessary to address the various components of frailty in transplant candidates.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Thijmen Visseren, Nicole S. Erler, Julie K. Heimbach, John E. Eaton, Nazia Selzner, Aliya Gulamhusein, Frans van Der Heide, Robert J. Porte, Bart van Hoek, Ian P. J. Alwayn, Herold J. Metselaar, Jan N. M. IJzermans, Sarwa Darwish Murad
Summary: This study aimed to identify risk factors for the recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (LT) in order to guide clinical management and prevention. The results showed that an increased inflammatory state before and after LT increased the incidence of rPSC. These inflammatory states are modifiable factors that could serve as targets for future studies and therapies.