Review
Cell Biology
Hui Kong, Ming-Li Sun, Xin-An Zhang, Xue-Qiang Wang
Summary: By investigating the roles and interactions of miRNA, lncRNA, and circRNA in osteoarthritis, their significance in the prevention, diagnosis, and treatment of OA can be identified as potential future therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Jiefeng Liu, Yuhua Feng, Xinyu Zeng, Miao He, Yujing Gong, Yiping Liu
Summary: This study reveals the role of VPS9D1-AS1 in the malignant progression of LUAD through the regulation of the miRNA-30a-5p/KIF11 axis.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Jingjing Huang, Shiyao Jiang, Lu Liang, Hua He, Yueying Liu, Li Cong, Yiqun Jiang
Summary: This study identified lncRNAs associated with COAD metastasis and PANoptosis and found that one lncRNA (SNHG7) was significantly related to COAD prognosis. The study revealed the crucial role of lncRNA SNHG7 in drug resistance in COAD, suggesting it as a potential target for diagnosis and treatment of COAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Youting Dang, Yunping Zhou, Xuehai Ou, Qiang Wang, Dengke Wei, Fei Xie
Summary: In this study, lncRNA AC007207.2 was found to be over-expressed in osteosarcoma (OS) tissues and cell lines, leading to a worse prognosis. It was also discovered that AC007207.2 promotes proliferation and metastasis of OS cells through the miR-1306-5p/SIRT7 axis, while miR-1306-5p can inhibit the malignant behavior of OS cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Respiratory System
Chang Liu, Haifeng Li, Xiaojing Li, Xuejing Zhao, Xia Zhang
Summary: In lung adenocarcinoma (LUAD), the expression of lncRNA MANCR is significantly upregulated and is associated with poor prognosis. Downregulation of MANCR leads to decreased expression of proteins related to invasion, migration, cell cycle, and proliferation, while increasing apoptosis-related proteins. Silencing MANCR inhibits cancer cell functions, halts cell cycle progression, and promotes cell apoptosis in vitro experiments.
BMC PULMONARY MEDICINE
(2021)
Article
Oncology
Xiulin Jiang, Min Chen, Junyi Du, Hong Bi, Xiang Guo, Chao Yang, Xu He, Zhixian Jin
Summary: The study found that AC068228.1 is significantly upregulated in lung adenocarcinoma (LUAD), correlating with adverse clinical outcomes and serving as a prognostic marker. Additionally, it is associated with immune cell infiltration, suggesting its potential as a diagnostic and prognostic biomarker for LUAD patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yongan Song, Leonardo Kelava, Lu Zhang, Istvan Kiss
Summary: This study identified miRNAs involved in lung adenocarcinoma (LUAD) through bioinformatics analysis. It was found that hsa-miR-30a-3p may suppress the occurrence and progression of lung cancer through Wnt and AKT signaling pathways, becoming a potential biomarker in LUAD. In addition, hsa-miR-3944 and hsa-miR-3652 were identified as potential new biomarkers in LUAD.
Article
Biotechnology & Applied Microbiology
Jin Zhang, Rui Zhang, Yongju Ye
Summary: The study revealed that lncRNA SNHG7 could impact the degradation of EIF4G2, thereby regulating the sensitivity of ovarian cancer to Paclitaxel and inhibiting cell viability, migration, and invasion. The interaction between lncRNA SNHG7 and EIF4G2 plays a crucial role in the migrative and invasive activity as well as Paclitaxel resistance of ovarian cancer cells.
Article
Cell Biology
Xuefei Liu, Ziwei Luo, Xuechen Ren, Zhihang Chen, Xiaoqiong Bao, Jianghua Zheng, Zhixiang Zuo
Summary: This study comprehensively analyzed the cell-cell communications in pancreatic ductal adenocarcinoma (PDAC) and identified ligand-receptor pairs that contribute to the immunosuppressive microenvironment. A Malignant-Immune cell crosstalk (MIT) score was established to predict survival and therapy response in PDAC patients. The findings provide potential targets for new immunotherapy strategies and a prognostic indicator for PDAC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Chaonan Zhu, Shuai Wang, Maogen Zheng, Zhiquan Chen, Guochen Wang, Jun Ma, Bin Zhang, Wuhao Huang, Xiaoyan Sun, Changli Wang
Summary: The study reveals that miR-31-5p promotes cell progression in lung adenocarcinoma (LUAD) through the TNS1/p53 axis.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Yanting Dong, Tong Qiu, Yunpeng Xuan, Ao Liu, Xiao Sun, Zhangfeng Huang, Wenhao Su, Wenxing Du, Tianxiang Yun, Yang Wo, Alfons Navarro, Wenjie Jiao
Summary: In this study, circFBXW7 was found to inhibit proliferation and migration of LUAD cell lines by controlling the miR-942-5p/BARX2 axis, with its levels correlating with patient survival. This suggests that regulating circFBXW7 could have therapeutic value in treating LUAD patients.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Cell Biology
Jin Xu, Weixue Xu, Xuan Yang, Zhen Liu, Qinyun Sun
Summary: This study revealed that overexpression of lncRNA HCG11 in pancreatic carcinoma samples promoted cancer growth and aggressiveness, while inhibiting apoptosis. Knockdown of HCG11 suppressed the progression of pancreatic carcinoma cells. Bioinformatics analysis showed that HCG11 upregulated MDM2 expression by competitively targeting miR-579-3p. These findings suggest that HCG11 plays a significant role in the progression of pancreatic carcinoma.
Article
Oncology
Wei Xiong, Dan Liu, Xi Chen, Leiting Liu, Weihong Xiao
Summary: In this study, the up-regulation of lncRNA JPX in osteosarcoma (OS) tissues and cells was found, and it was revealed that JPX regulates OS cell proliferation, migration, and invasion through miR-33a-5p. Additionally, the down-regulation of miR-33a-5p led to the upregulation of PNMA1, and the depletion of PNMA1 inhibited OS cell proliferation, migration, and invasion.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Min Zhou, Shutao Pan, Tingting Qin, Chunle Zhao, Taoyuan Yin, Yang Gao, Yuhui Liu, Zhenxiong Zhang, Yongkang Shi, Yu Bai, Jun Gong, Xingjun Guo, Min Wang, Renyi Qin
Summary: FAM83H-AS1 is highly expressed in PDAC patients and is associated with shorter survival. It promotes the proliferation, invasion, and metastasis of PDAC cells by protecting FAM83H mRNA from degradation. FAM83H protein has similar functions as FAM83H-AS1 in PDAC cells and can bind to beta-catenin, activating the Wnt/beta-catenin signaling pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Binliang Wang, Yuanyuan Cai, Xiaobo Li, Yiming Kong, Haiwei Fu, Jianying Zhou
Summary: C2CD4D-AS1 is significantly up-regulated in LUAD, and plays a role in regulating LUAD cell biological functions by interacting with ETV4, miR-3681-3p, NEK2 and other pathways.
