Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli
Summary: In this study, Andreano and Paciello et al. provide insights into the functional and genetic characteristics of the Omicron BA.1 and BA.2 cross-protective antibody response. Their findings reveal that SARS-CoV-2 vaccines can induce neutralizing antibodies that cross-neutralize the Omicron variants and SARS-CoV-1 virus.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Samuel P. C. Brand, John Ojal, Rabia Aziza, Vincent Were, Emelda A. Okiro, Ivy K. Kombe, Caroline Mburu, Morris Ogero, Ambrose Agweyu, George M. Warimwe, James Nyagwange, Henry Karanja, John N. Gitonga, Daisy Mugo, Sophie Uyoga, Ifedayo M. O. Adetifa, J. Anthony G. Scott, Edward Otieno, Nickson Murunga, Mark Otiende, Lynette Ochola-Oyier, Charles N. Agoti, George Githinji, Kadondi Kasera, Patrick Amoth, Mercy Mwangangi, Rashid Aman, Wangari Ng'ang'a, Benjamin Tsofa, Philip Bejon, Matt J. Keeling, D. James Nokes, Edwine Barasa
Summary: Policy decisions on COVID-19 interventions should take into account local, regional, and national understanding of SARS-CoV-2 transmission. Three epidemic waves have been observed in Kenya, with the first two attributed to differences in contact rates among high and low socioeconomic groups, and the third wave to the introduction of highly transmissible variants. Reopening of schools led to a slight increase in transmission between the second and third waves. Socioeconomic status and urban-rural population structure play critical roles in viral transmission in Kenya.
News Item
Multidisciplinary Sciences
Roxanne Khamsi
Summary: Evidence suggests that self-attacking autoantibodies may be crucial in understanding some of the most severe cases of SARS-CoV-2 infection.
News Item
Multidisciplinary Sciences
Holly Else
Summary: Researchers are attempting to calculate the number of years lost due to disability and death.
Article
Multidisciplinary Sciences
Pei Sen, Teresa K. Yamana, Sasikiran Kandula, Marta Galanti, Jeffrey Shaman
Summary: The COVID-19 pandemic in the United States in 2020 was characterized by increasing ascertainment rates, high population susceptibility, and rising community infectious rates, with infection fatality rate decreasing towards the end of the year.
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Engineering, Electrical & Electronic
Jesus Mirapeix Serrano, Ruben Ruiz-Lombera, Jose J. Valdiande, Adolfo Cobo, Jose Miguel Lopez-Higuera
IEEE SENSORS JOURNAL
(2016)
Article
Engineering, Industrial
J. Mirapeix, E. Vila, J. J. Valdiande, A. Riquelme, M. Garcia, A. Cobo
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2016)
Article
Otorhinolaryngology
David Lobo, Pedro Anuarbe, Jose Miguel Lopez-Higuera, Jaime Viera, Nathalia Castillo, Roberto Megia
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Letter
Otorhinolaryngology
Jaime Viera-Artiles, Jose J. Valdiande, Javier Ospina, Maria Costales, Jose M. Lopez-Higuera
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2020)
Article
Otorhinolaryngology
Jaime Viera-Artiles, Patricia Corriols-Noval, Eugenia Lopez-Simon, Rocio Gonzalez-Aguado, David Lobo, Roberto Megia
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Medicine, General & Internal
Elisabeth Ninchritz-Becerra, Maria Montserrat Soriano-Reixach, Miguel Mayo-Yanez, Christian Calvo-Henriquez, Paula Martinez-Ruiz de Apodaca, Carlos Saga-Gutierrez, Pablo Parente-Arias, Itzhel Maria Villareal, Jaime Viera-Artiles, Daniel Poletti-Serafini, Isam Alobid, Tareck Ayad, Sven Saussez, Jerome R. Lechien, Carlos M. Chiesa-Estomba
Summary: In Spain, a high prevalence of taste and smell disorders was found among COVID-19 patients, with females being more affected, and an early olfactory recovery rate of 68.2% observed.
Article
Otorhinolaryngology
Jaime Viera-Artiles, David Mato, Jose J. Valdiande, David Lobo, Juan Pedraja, Jose M. Lopez-Higuera, Javier Ospina
Summary: The midfacial mask designed in this study effectively maintains negative pressure, evacuating human adult exhalation and reducing aerosol spread. It is more effective than hand suction instruments and achieves a 72% reduction in splatter created from fluorescein atomization.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jose J. Valdiande, Luis Rodriguez-Cobo, Adolfo Cobo, Jose Miguel Lopez-Higuera, Jesus Mirapeix
Summary: In this study, plasma optical spectroscopy was used to investigate welding defects during the manufacture of tanker trucks. The results show that analyzing process signals can effectively detect and identify defects and their causes.
APPLIED SCIENCES-BASEL
(2022)
Article
Spectroscopy
J. J. Valdiande, M. Martinez-Minchero, A. Cobo, J. M. Lopez-Higuera, J. Mirapeix
Summary: This study uses plasma optical spectroscopy and laser-induced breakdown spectroscopy to analyze the effects of different perturbations on a tungsten inert gas welding process. By analyzing and comparing the spectra acquired with two setups, more information about the process evolution, dynamics, and chemical composition of the seams is obtained. The analysis of different elements provides rich information about weld quality and enables online monitoring of arc welding processes. Elements such as lithium or sodium, which are not commonly used in spectroscopic analysis of welding processes, provide interesting information on surface defects and contamination. Additionally, LIBS 2D scanning allows for a detailed analysis of the resulting elemental distributions.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Article
Medicine, Research & Experimental
David Lobo, Ramon Sancibrian, Angela Mesones, Jose Ramon Llata, Monica Williams, Jaime Viera-Artiles
Summary: The main objective of this study was to develop and evaluate a new exoskeleton system designed to provide ergonomic assistance to surgeons during endoscopic sinus and skull base surgical procedures. Through five experiments in different scenarios, it was found that volunteers felt more comfortable and experienced less fatigue and pain when using the exoskeleton. The initial results showed excellent performance in reducing pain and fatigue and improving efficiency.
Review
Medicine, General & Internal
Christian Calvo-Henriquez, Jaime Viera-Artiles, Miguel Rodriguez-Iglesias, Paula Rodriguez-Rivas, Antonino Maniaci, Miguel Mayo Yanez, Gabriel Martinez-Capoccioni, Isam Alobid
Summary: Chronic rhinosinusitis is a common condition that is often treated with intranasal corticosteroids. However, the delivery of these sprays into the sinus cavities is often inadequate. Recent studies have shown that high-volume steroid nasal rinses have better penetration into the sinuses. This review of the literature suggests a potential positive effect of high-volume steroid nasal rinses in chronic rhinosinusitis, especially when it is accompanied by nasal polyps. However, more well-designed studies are needed for solid conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Jason Lee, Alia Tayara, James D. Warren, Boris Kuyeb, Elizabeth McKee, Alexander Velazquez, Oishika Paul, Andrea F. Lewis
Summary: The purpose of the study was to understand the impact of COVID-19 on facial trauma incidence and etiology in Mississippi. The research found a significant increase in facial trauma caused by family members during the pandemic, which may be related to the reported increase in domestic violence. Additionally, there were notable changes in the etiology and insurance payor of facial trauma cases during the COVID-19 pandemic.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Sheila Moran, Cassidy Anderson, Risha Sheni, Monica Azmy, Daniel T. Li, Anthony M. Loizides, Christina J. Yang
Summary: This retrospective study found that a family history of eczema and a dairy-free diet may be associated with an increased risk of future diagnosis of EoE in children with aerodigestive dysfunction.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Robert Brinton Fujiki, Amanda Edith Fujiki, Susan L. Thibeault
Summary: This study examined the number of therapy sessions required for patients with EILO/ILO to sufficiently improve their symptoms. The results showed that patients with comorbid behavioral health diagnosis, higher vocal handicap index score, and reduced physical activity due to EILO/ILO symptoms required more therapy sessions. Patients with secondary environmental triggers also required more sessions. Only a small percentage of patients returned for additional therapy sessions after discharge, and they were mostly from affluent neighborhoods.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Brian W. Herrmann, Salina H. Goff, Juri Boguniewicz, Sarah A. Gitomer
Summary: This retrospective case series analyzed nHiB H. influenzae meningitis cases diagnosed at Children's Hospital Colorado from 2000 to 2020. The results showed that nHiB H. influenzae can cause both transient and permanent postmeningitic hearing loss. The use of steroids may offer otoprotection in nHiB H. influenzae meningitis. Further research is needed to better understand hearing outcomes after nHiB H. influenzae meningitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
M. Kovacs, J. Uzsaly, G. Bodzai, I. Pap, B. Lippai, T. Dergez, A. Nemeth, I. Gerlinger, I. Szanyi, P. Bako
Summary: The pathophysiology and treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are still debated. A randomized controlled trial showed no significant differences in hearing improvement between different treatments, but identified clinical factors such as vertigo, cardiovascular comorbidity, and initial hearing loss severity as significant predictors of hearing outcomes.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Roee Noy, Yotam Shkedy, Nadeem Habashi, Salem Billan, Jacob Cohen
Summary: Salvage cordectomy offers favorable larynx preservation rates and oncological outcomes for recurrent glottic cancer amenable to conservative surgery. Smoking, advanced age, and advanced tumor stages are associated with salvage cordectomy failure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Pietro De Luca, Ignazio La Mantia, Federico Maria Gioacchini, Massimo Re, Marco Radici, Angelo Camaioni, Arianna Di Stadio
Summary: In this study, the effect of nasal packaging using Fitostimoline (R) gauze on nasal outcomes after septoplasty and FESS surgery was evaluated. The results showed that the use of Fitostimoline (R) gauze improved healing of nasal mucosa and reduced discomfort during tampon removal.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Anna Frants, Antonios N. Varelas, Alexa M. Franco, W. Matthew White, Minas S. Constantinides, Philip J. Miller, Judy W. Lee
Summary: This article introduces DESS as a new educational format to increase the comfort of residents with the surgical evaluation and intraoperative planning of rhinoplasty. Through DESS, residents display significant improvement in their comfort with facial nasal analysis and overall surgical preparation.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
Summary: This study compared the operation time, graft success, audiometric outcomes, and complications of the over-under technique using temporalis fascia and cartilage grafts for repairing large perforations. The results showed that both techniques had similar graft success rates and hearing outcomes, but the temporalis fascia graft technique prolonged the operation time and increased the risk of re-perforation and graft atelectasis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Ciaran Lane, Maxwell Wright, Janice Linton, Neerav Goyal
Summary: This study systematically reviewed the data on surgical closure of enlarged tracheoesophageal fistula after laryngectomy and compared different reconstruction techniques. The results showed that using vascularized tissue for reconstruction had a higher success rate compared to primary closure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
John Q. Odom, Andrew R. Mangan, Anna Celeste Gibson, Michael Larson, John L. Dornhoffer, Robert A. Saadi
Summary: Granulomatosis with polyangiitis is often associated with otolaryngologic complaints, and in rare cases, patients may experience facial nerve palsy. It is important for healthcare professionals to recognize facial nerve palsy as a potential presentation of granulomatosis with polyangiitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
R. Bar, A. Mattei, R. Haddad, A. Giovanni
Summary: Office-based flexible interventional laryngoscopy under local anesthesia is a safe and well-tolerated procedure, suitable for various ambulatory and office-based settings.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Do Hyun Kim, Soo Whan Kim, Sung Won Kim, Gulnaz Stybayeva, Se Hwan Hwang
Summary: This systematic review and meta-analysis compared the effects of cryotherapy and radiofrequency neurolysis in treating rhinitis-related symptoms caused by ablation of the posterior nasal nerves. The results showed that both cryotherapy and radiofrequency neurolysis significantly improved rhinitis-related symptoms and quality of life. Radiofrequency neurolysis was found to be more effective than cryotherapy in reducing total nasal symptom scores.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Mengdie Gao, Liyu Cheng, Qingcui Wang, Qingwen Yang, Xiaoyi Wang, Yanru Li, Rong Hu, Wen Xu
Summary: This study investigates the clinical characteristics, diagnosis, and prognosis of patients with laryngeal tuberculosis (LTB) combined with respiratory tuberculosis. The study found that LTB commonly affects middle-aged men and presents with symptoms such as hoarseness, abnormal sensation of pharyngeal, and pharyngalgia. The lesions mainly involve multiple subregions, primarily the glottis, and can also involve the pharynx. Half of the patients were complicated with pulmonary tuberculosis (PTB), and chest CT was superior to X-ray in detecting pulmonary lesions. Most patients showed significant improvement in symptoms and morphology of the pharyngeal and laryngeal mucosa after regular anti-tuberculosis treatment.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Alfonso Scarpa, Emilio Avallone, Mario Carucci, Giovanni Salzano, Giuseppe Chiarella, Claudia Cassandro, Pasquale Viola, Filippo Ricciardiello, Massimo Ralli, Pietro De Luca, Francesco Antonio Salzano
Summary: This study assessed the efficacy and safety of low-dose intratympanic gentamicin for vertigo attacks in Meniere's disease. The treatment significantly reduced vertigo attacks without causing hearing deterioration. The method primarily affected vestibular function while preserving cochlear integrity. These findings suggest that a low-dose, clinical symptomatology-based gentamicin treatment regimen could be an effective and safe strategy for managing unilateral Meniere's disease.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)