Article
Medicine, General & Internal
Mingyang Song, Louise Emilsson, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: After adjusting for family history of CRC, siblings and children of patients with colorectal polyps are still at higher risk of CRC, especially early onset CRC. The association between family history of polyps and CRC risk is strengthened by the increasing number of first degree relatives with polyps and decreasing age at polyp diagnosis. Early screening for CRC might be considered for first degree relatives of patients with polyps.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Oncology
Qianqian Du, Jingyu Chen, Ya Meng, Ni Gong, Xiaodan Wu, Qiyuan Lyu, Yiheng Zhang, Xiaoyu Wu, Meifen Zhang
Summary: In China, the participation of first-degree relatives in colorectal cancer screening is low, with perceived susceptibility and perception of barriers being the most important influencing factors.
Article
Gastroenterology & Hepatology
Carla J. Gargallo-Puyuelo, Angel Lanas, Patricia Carrera-Lasfuentes, Angel Ferrandez, Enrique Quintero, Marta Carrillo, Inmaculada Alonso-Abreu, Maria Asuncion Garcia-Gonzalez
Summary: Epidemiological studies suggest that having a first-degree relative with colorectal cancer (CRC) increases the risk of developing the disease. This study found significant differences in genotype distribution of CRC risk-related SNPs between first-degree relatives of CRC patients and individuals with no family history of CRC. Genotyping of CRC risk variants in first-degree relatives of CRC patients could help identify individuals at risk who may benefit from increased surveillance and CRC screening programs.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xueying Zhang, Yiheng Zhang, Jingyu Chen, Meifen Zhang, Ni Gong
Summary: The study identified three main reasons for low screening participation among FDRs, including emotional distance from medicine, reliance on routine health examination results to confirm health status, and considering screening as distant from daily life and not a priority. Healthcare professionals should focus on narrowing the psychological distance between individuals and screening to encourage participation.
Article
Oncology
Heather M. Ochs-Balcom, Priyanka Kanth, Lisa A. Cannon-Albright
Summary: Research has shown that first- and second-degree relatives of early-onset CRC cases have elevated risks of developing early-onset CRC, with respective RRs of 6.0 and 3.1. Family history contributes to non-syndromic early-onset CRC, and the affected location may not necessarily be similar to that of the relatives.
CANCER EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Mireia Obon-Santacana, Anna Diez-Villanueva, Maria Henar Alonso, Gemma Ibanez-Sanz, Elisabet Guino, Ana Lopez, Lorena Rodriguez-Alonso, Alfredo Mata, Ana Garcia-Rodriguez, Andres Garcia Palomo, Antonio J. Molina, Montse Garcia, Gemma Binefa, Vicente Martin, Victor Moreno
Summary: Different risk-based colorectal cancer screening strategies, including the use of polygenic risk scores, have been evaluated to enhance effectiveness. This study assessed the utility of polygenic risk scores in a fecal immunochemical test-based screening program and found that while it plays a role along the CRC tumorigenesis pathway, its ability to stratify the general population or act as a second test after a positive FIT result remains uncertain.
Article
Oncology
Kai Wang, Ola Olen, Louise Emilsson, Hamed Khalili, Jonas Halfvarson, Mingyang Song, Jonas F. Ludvigsson
Summary: This study examines the association between a history of inflammatory bowel disease (IBD) in first-degree relatives (FDRs) and the risk of colorectal cancer (CRC). The researchers conducted a case-control study in Sweden among 69,659 CRC cases and 343,032 non-CRC controls. They found that having FDRs with IBD history did not increase the risk of CRC. These findings suggest that extra screening for CRC may not be necessary in the relatives of IBD patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Nursing
Rujin Li, Caixia Li, Li Liu, Weicong Chen, Yang Bai
Summary: This study aims to explore factors influencing colonoscopy screening behavior among first-degree relatives (FDRs) of colorectal cancer (CRC) patients according to the ecological model.
WORLDVIEWS ON EVIDENCE-BASED NURSING
(2023)
Article
Public, Environmental & Occupational Health
Mark A. Fiala
Summary: This study investigated the factors associated with colorectal cancer (CRC) screening adherence. The results showed that first-degree relatives (FDRs) of individuals with CRC were more likely to adhere to the screening recommendations. Factors such as race, ethnicity, and socioeconomic status were also associated with adherence. Further outreach is needed for minority races, the Hispanic community, and individuals with limited finances and no insurance to improve CRC screening accessibility.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Dan Li, Amanda R. Doherty, Menaka Raju, Liyan Liu, Nan Ye Lei, Laura B. Amsden, Jeffrey K. Lee, Theodore R. Levin, Douglas A. Corley, Lisa J. Herrinton
Summary: This community-based, case-control study found a close association between serrated polyps (SPs) and the risk of colorectal cancer (CRC), especially large proximal serrated lesions or those with dysplasia. Close endoscopic surveillance of serrated polyps can help reduce the risk of CRC. Proximal unspecified SPs are also associated with an increased risk of CRC and should be managed as serrated lesions.
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Guoqiao Zheng, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: Individuals with a family history of both CRCa-1 and CRCa-2 have a lower risk of CRC compared to individuals with only CRCa-1, which is related to the age of diagnosis of CRC in FDR and family relationships.
Article
Oncology
Yang Bai, Cho Lee Wong, Jieling Chen, Winnie K. W. So
Summary: This study evaluated the process of a tailored communication intervention for first-degree relatives of colorectal cancer patients. The results showed that in the intervention group, most participants received written and verbal sessions and reported high satisfaction. Mediation and moderation analysis revealed that perceived barriers and cues to action played a mediating role in the intervention effect. The study also identified potential strategies to enhance the tailored effect.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Review
Biochemistry & Molecular Biology
Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer Srivastava
Summary: Molecular subtypes-based therapies provide a new potential framework for precise outcomes in clinical settings, as colorectal cancer is a highly heterogeneous malignancy with different pathological and genetic signatures in each subtype. Designing therapeutic stratification based on these features may lead to improved treatment outcomes.
Article
Public, Environmental & Occupational Health
Jingru Zhou, Li Zhao, Yanjun Liu, Lin He, Fang Yang, Haichao Wang, Jing Fan, Qianer Li, Sisi Guo, Yanfen Wang, Yan Liu, Dan Zhou, Qin Tan
Summary: A family history of colorectal cancer is a major risk factor for colorectal cancer in China. This study aimed to examine the mediating effects of health beliefs on the relationship between health-promoting lifestyle and health information literacy among first-degree relatives of colorectal cancer patients. The results showed that health information literacy and health beliefs are key factors associated with a health-promoting lifestyle among first-degree relatives with colorectal cancer.
FRONTIERS IN PUBLIC HEALTH
(2023)