Article
Medical Laboratory Technology
Ritu Lal, Aaron Ellenbogen, Barry Gidal
Summary: Gabapentin enacarbil administration leads to consistent bioavailability of gabapentin, showing low interindividual variability.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Psychology, Clinical
Erica N. N. Grodin, Amanda K. K. Montoya, Alondra Cruz, Suzanna Donato, Wave-Ananda Baskerville, Lara A. A. Ray
Summary: This study used two machine-learning methods to examine the treatment of alcohol use disorder. The results showed that smoking status, AUD severity, medication adherence, and drinking goal can predict treatment response. The integration of machine-learning methods has the potential to inform clinical practice.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Review
Substance Abuse
Anna G. Mattle, Patrick McGrath, Austin Sanu, Rajesh Kunadharaju, Brian Kersten, Kimberly Zammit, Manoj J. Mammen
Summary: There is insufficient evidence to support the widespread use of gabapentin for the treatment of alcohol withdrawal syndrome (AWS) in hospitalized patients, particularly as a replacement for benzodiazepines. The systematic review and meta-analysis revealed no significant differences between gabapentin-treated and benzodiazepine-treated groups in terms of symptom resolution time, benzodiazepine usage, withdrawal-related complications, or hospital length of stay (LOS). However, limited subgroup analyses showed potential benefits of gabapentin in severe AWS patients and in patients receiving only gabapentin without benzodiazepines. More well-designed studies are needed to evaluate the effectiveness of gabapentin in treating AWS.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
John J. Mariani, Martina Pavlicova, Cale Basaraba, Agnieszka Mamczur-Fuller, Daniel J. Brooks, Adam Bisaga, Kenneth M. Carpenter, Edward Nunes, Frances R. Levin
Summary: The pilot study showed that high-dose gabapentin was more effective in reducing harmful alcohol consumption and increasing percent days abstinent in actively drinking outpatients with AUD.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Substance Abuse
Charles E. Murphy, Ralph C. Wang, Juan Carlos Montoy, Evans Whittaker, Maria Raven
Summary: The study showed that extended-release naltrexone can reduce the number of drinking days and heavy drinking days per month in patients with AUD, with larger reductions seen with longer duration of treatment.
Review
Biochemistry & Molecular Biology
Hidetoshi Komatsu, Emi Watanabe, Mamoru Fukuchi
Summary: Learning and environmental adaptation are crucial for survival and quality of life, with decision-making involving coordination among multiple neural network systems. Neurological and psychiatric disorders often impact these processes, but machine learning approaches have the potential to redefine mental illnesses and improve therapeutic outcomes. Early disease detection and personalized treatment regimes may be possible through measurable endophenotypes and the application of artificial intelligence in psychiatric practice.
Article
Pharmacology & Pharmacy
Katrina Ciraldo, Manuel Seraydarian, James Gasper, Triveni DeFries, Marlene Martin
Summary: This study aimed to investigate the safety of using XR-NTX for the treatment of alcohol use disorder in individuals on therapeutic anticoagulation. Through a retrospective chart review of six cases, it was found that no complications were documented in individuals receiving XR-NTX while on therapeutic anticoagulation.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Gene Y. Im, Jessica L. Mellinger, Adam Winters, Elizabeth S. Aby, Zurabi Lominadze, John Rice, Michael R. Lucey, Juan P. Arab, Aparna Goel, Loretta L. Jophlin, Courtney B. Sherman, Richard Parker, Po-Hung Chen, Deepika Devuni, Sandeep Sidhu, Winston Dunn, Gyongyi Szabo, Ashwani K. Singal, Vijay H. Shah
Summary: The survey of hepatology and gastroenterology providers showed high rates of alcohol screening and referrals for behavioral therapy, but low rates of prescribing AUD pharmacotherapy due to knowledge gaps from insufficient education. Further studies are needed to improve provider alignment with best practices for treating patients with AUD and ALD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Eugene Laska, Carole Siegel, Ziqiang Lin
Summary: This study provides a method to compare the effects of test treatment T and reference treatment R among participants who are likely responders to T. By using a prognostic score function, participants who are likely responders to T can be matched with those randomized to R, resulting in comparable treatment groups with common covariance distribution. Treatment comparison is then based on observed outcomes in this enriched sample.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Nutrition & Dietetics
Liat Hen-Herbst, Meital Ron El Levin, Yehuda Senecky, Sigal Frishman, Andrea Berger
Summary: This study assessed the knowledge, professional practices, and self-perceived competence of Israeli nutritionists regarding the risks of alcohol consumption during pregnancy. The results showed that the nutritionists lacked sufficient knowledge to guide pregnant women, and the duration of experience, self-perceived competence, and knowledge score influenced their professional practices. Nutritionists and other healthcare professionals have a crucial role in preventing FASD.
Article
Psychiatry
Xu Chen, Yunmeng Pan, Peiru Xu, Yi Huang, Nan Li, Yun Song
Summary: The study found that men whose fathers drank frequently during their childhood and were encouraged to drink are more likely to develop alcohol use disorder in adulthood. In addition, being induced to drink during childhood, father's alcohol consumption, smoking history, and years of education are also identified as risk or protective factors.
Article
Chemistry, Physical
Azin Abdollahi, Zahra Ansari, Mohammad Akrami, Ismaeil Haririan, Simin Dashti-Khavidaki, Mohammad Irani, Mojtaba Kamankesh, Emad Ghobadi
Summary: An extended-release tablet of tacrolimus as once-daily dosing was fabricated using 3D printing technology. The tablet was developed by combining two 3D-printing methods and met the USP requirements for weight variation, friability, hardness, assay, and content uniformity. SEM analysis showed smooth surfaces with multiple deposited layers, and there was no decomposition of the polymer and drug observed at the printing temperature. The novel 3D-printed tablet with tailored dosing and specific kinetic release has the potential to be used for personalized medicine.
Article
Health Care Sciences & Services
Ghada Mubarak, Farah R. Zahir
Summary: With the rise of genome-wide screening methods, precision and personalized medicine have seen significant development. Transcriptomics and epitranscriptomics have emerged as important fields in defining disease causes and exploring therapeutic benefits. Advances in these fields have contributed to diagnostics and disease pathophysiological studies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Substance Abuse
Thibaut Davy-Mendez, Varada Sarovar, Tory Levine-Hall, Alexandra N. Lea, Stacy A. Sterling, Felicia W. Chi, Vanessa A. Palzes, Kendall J. Bryant, Constance M. Weisner, Michael J. Silverberg, Derek D. Satre
Summary: The study found that people with HIV who have alcohol use disorders are more likely to have depression and non-alcohol substance use disorders. However, after adjusting for various factors, there was no significant difference in the rates of receiving AUD treatment between HIV-positive individuals and HIV-negative individuals.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Emergency Medicine
Kiran Punia, William Scott, Kriti Manuja, Monica Sabbineni, Kaitryn Campbell, Iris M. Balodis, James Mackillop
Summary: This systematic review evaluates the efficacy of anti-craving medications for the treatment of alcohol use disorder (AUD) in the emergency department (ED). The existing evidence is limited, but supports the use of naltrexone pharmacotherapy, particularly extended-release injections. More randomized controlled trials are needed for substantive direct evidence.
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ruoting Yang, Gwyneth W. Y. Wu, Josine E. Verhoeven, Aarti Gautam, Victor Reus, Jee In Kang, Janine D. Flory, Duna Abu-Amara, Leroy Hood, Francis J. Doyle, Rachel Yehuda, Charles R. Marmar, Marti Jett, Rasha Hammamieh, Synthia H. Mellon, Owen M. Wolkowitz
Summary: The study revealed that individuals with PTSD experience accelerated biological aging compared to controls, with changes in PTSD symptoms severity and T-cell senescence contributing to this acceleration.
MOLECULAR PSYCHIATRY
(2021)
Article
Substance Abuse
Anna Mejldal, Kjeld Andersen, Silke Behrendt, Randi Bilberg, Michael Bogenschutz, Barbara Braun-Michl, Gerhard Buehringer, Anette Sogaard Nielsen
Summary: The study showed that reductions in WHO risk levels were maintained over time in older adults seeking treatment for AUD, and were associated with decreased consequences of drinking and AUD symptoms, as well as minor but statistically significant improvements in quality of life.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, Marcela G. Ot'alora, Wael Garas, Casey Paleos, Ingmar Gorman, Christopher Nicholas, Michael Mithoefer, Shannon Carlin, Bruce Poulter, Ann Mithoefer, Sylvestre Quevedo, Gregory Wells, Sukhpreet S. Klaire, Bessel van der Kolk, Keren Tzarfaty, Revital Amiaz, Ray Worthy, Scott Shannon, Joshua D. Woolley, Cole Marta, Yevgeniy Gelfand, Emma Hapke, Simon Amar, Yair Wallach, Randall Brown, Scott Hamilton, Julie B. Wang, Allison Coker, Rebecca Matthews, Alberdina de Boer, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.
Editorial Material
Neurosciences
Carole Siegel, Eugene Laska
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Gwyneth W. Y. Wu, Owen M. Wolkowitz, Victor I. Reus, Jee In Kang, Mathea Elnar, Reuben Sarwal, Janine D. Flory, Duna Abu-Amara, Rasha Hammamieh, Aarti Gautam, Francis J. Doyle Iii, Rachel Yehuda, Charles R. Marmar, Marti Jett, Synthia H. Mellon
Summary: Research on the correlation between blood levels of brain-derived neurotrophic factor (BDNF) and post-traumatic stress disorder (PTSD) has yielded conflicting results. This study found that combat veterans with PTSD had significantly higher serum BDNF levels compared to those without PTSD, both in cross-sectional and longitudinal analysis. However, serum BDNF levels did not correlate with PTSD symptom severity within the PTSD group at different time points.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rohit Rao, Pramod Somvanshi, Elizabeth B. Klerman, Charles Marmar, Francis J. Doyle
Summary: Chronic sleep deficiency is common in modern society and is associated with increased risk of metabolic and other diseases. Cortisol, the primary hormone of the HPA axis, shows significant circadian rhythmicity and is influenced by sleep, wake states, and other physiology. Studies suggest that chronic sleep deficiency may lead to pathophysiological changes through its effects on the HPA axis.
Article
Neurosciences
Sabra S. Inslicht, Andrea N. Niles, Thomas J. Metzler, Sa'ar L. Lipshitz, Christian Otte, Mohammed R. Milad, Scott P. Orr, Charles R. Marmar, Thomas C. Neylan
Summary: This study found that a single dose of hydrocortisone and D-Cycloserine can facilitate fear extinction learning in individuals with PTSD symptoms, with reduced skin conductance response during extinction learning, especially in the DCS and HC groups compared to placebo. These findings suggest that glucocorticoids and NMDA agonists hold promise for enhancing extinction learning in PTSD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Adam X. Maihofer, Karmel W. Choi, Jonathan R. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, Renato Polimanti, Andrew Ratanatharathorn, Katy Torres, Aliza P. Wingo, Clement C. Zai, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegovic, Anders D. Borglum, Dragan Babic, Marie Baekvad-Hansen, Dewleen G. Baker, Jean C. Beckham, Laura J. Bierut, Jonathan Bisson, Marco P. Boks, Elizabeth A. Bolger, Bekh Bradley, Meghan Brashear, Gerome Breen, Richard A. Bryant, Angela C. Bustamante, Jonas Bybjerg-Grauholm, Joseph R. Calabrese, Jose M. Caldas-de-Almeida, Chia-Yen Chen, Anders M. Dale, Shareefa Dalvie, Jurgen Deckert, Douglas L. Delahanty, Michelle F. Dennis, Seth G. Disner, Katharina Domschke, Laramie E. Duncan, Alma Dzubur Kulenovic, Christopher R. Erbes, Alexandra Evans, Lindsay A. Farrer, Norah C. Feeny, Janine D. Flory, David Forbes, Carol E. Franz, Sandro Galea, Melanie E. Garrett, Aarti Gautam, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F. Gillespie, Aferdita Goci, Scott D. Gordon, Guia Guffanti, Rasha Hammamieh, Michael A. Hauser, Andrew C. Heath, Sian M. J. Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Karen-Inge Karstoft, Milissa L. Kaufman, Ronald C. Kessler, Alaptagin Khan, Nathan A. Kimbrel, Anthony P. King, Nastassja Koen, Henry R. Kranzler, William S. Kremen, Bruce R. Lawford, Lauren A. M. Lebois, Catrin Lewis, Israel Liberzon, Sarah D. Linnstaedt, Mark W. Logue, Adriana Lori, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Jessica L. Maples-Keller, Charles Marmar, Nicholas G. Martin, Douglas Maurer, Matig R. Mavissakalian, Alexander McFarlane, Regina E. McGlinchey, Katie A. McLaughlin, Samuel A. McLean, Divya Mehta, Rebecca Mellor, Vasiliki Michopoulos, William Milberg, Mark W. Miller, Charles Phillip Morris, Ole Mors, Preben B. Mortensen, Elliot C. Nelson, Merete Nordentoft, Sonya B. Norman, Meaghan O'Donnell, Holly K. Orcutt, Matthew S. Panizzon, Edward S. Peters, Alan L. Peterson, Matthew Peverill, Robert H. Pietrzak, Melissa A. Polusny, John P. Rice, Victoria B. Risbrough, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Kenneth J. Ruggiero, Ariane Rung, Bart P. F. Rutten, Nancy L. Saccone, Sixto E. Sanchez, Dick Schijven, Soraya Seedat, Antonia Seligowski, Julia S. Seng, Christina M. Sheerin, Derrick Silove, Alicia K. Smith, Jordan W. Smoller, Scott R. Sponheim, Dan J. Stein, Jennifer S. Stevens, Martin H. Teicher, Wesley K. Thompson, Edward Trapido, Monica Uddin, Robert J. Ursano, Leigh Luella van den Heuvel, Miranda Van Hooff, Eric Vermetten, Christiaan H. Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Thomas Werge, Michelle A. Williams, Douglas E. Williamson, Sherry Winternitz, Christiane Wolf, Erika J. Wolf, Rachel Yehuda, Keith A. Young, Ross McD Young, Hongyu Zhao, Lori A. Zoellner, Magali Haas, Heather Lasseter, Allison C. Provost, Rany M. Salem, Jonathan Sebat, Richard A. Shaffer, Tianying Wu, Stephan Ripke, Mark J. Daly, Kerry J. Ressler, Karestan C. Koenen, Murray B. Stein, Caroline M. Nievergelt
Summary: This study combines a quantitative measurement of posttraumatic stress disorder (PTSD) phenotype with lifetime trauma exposure (LTE) information to identify novel risk loci and demonstrate a high genetic overlap between PTSD and LTE.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Burook Misganaw, Ruoting Yang, Aarti Gautam, Seid Muhie, Synthia H. Mellon, Owen M. Wolkowitz, Kerry J. Ressler, Francis J. Doyle, Charles R. Marmar, Marti Jett, Rasha Hammamieh
Summary: There is a significant link between post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS), both in terms of phenotype and genetics, which may help explain the increased prevalence of MetS among PTSD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Lindsay A. Jibb, Stephanie M. Nanos, Sarah Alexander, Carmine Malfitano, Anne Rydall, Sumit Gupta, Aaron D. Schimmer, Camilla Zimmermann, Sarah Hales, Rinat Nissim, Charles Marmar, Katharina Schultebraucks, Kenneth Mah, Gary Rodin
Summary: This study aims to determine the prevalence, severity, longitudinal course, and predictors of traumatic stress symptoms in family caregivers of patients with acute leukemia and to understand their lived experience of traumatic stress and support needs.
Article
Psychiatry
Mu Xu, Ziqiang Lin, Carole E. Siegel, Eugene M. Laska, Duna Abu-Amara, Afia Genfi, Jennifer Newman, Michelle K. Jeffers, Esther M. Blessing, Steven R. Flanagan, Silvia Fossati, Amit Etkin, Charles R. Marmar
Summary: Diagnosing PTSD and TBI is challenging, especially for providers lacking specialized training and facing time pressures. This study utilized blood tests to predict the diagnosis of PTSD and TBI, and found that markers of glucose metabolism and inflammation were significant in the models. These findings hold promise for the development of accessible and low-cost biomarker tests for PTSD and TBI in primary care and specialty settings.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Seid Muhie, Aarti Gautam, Ruoting Yang, Burook Misganaw, Bernie J. Daigle, Synthia H. Mellon, Janine D. Flory, Duna Abu-Amara, Inyoul Lee, Kai Wang, Ryan Rampersaud, Leroy Hood, Rachel Yehuda, Charles R. Marmar, Owen M. Wolkowitz, Kerry J. Ressler, Francis J. Doyle, Rasha Hammamieh, Marti Jett
Summary: Post-traumatic stress disorder (PTSD) is a complex condition that affects multiple systems. By analyzing multi-modal datasets, including proteomic, metabolomic, and epigenomic assays on blood samples, researchers have identified molecular signatures of PTSD in two cohorts of well-characterized veterans and active-duty soldiers. These molecular features indicate activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis, which may contribute to both psychiatric and physical comorbidities.
CELL REPORTS MEDICINE
(2023)
Meeting Abstract
Neurosciences
Mira Milad, Zhenfu Wen, Isabel Moallem, Michelle Jeffers, Esther M. Blessing, Duna Abu-Amara, Amit Etkin, Mohammed R. Milad, Charles R. Marmar
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Substance Abuse
C. R. Marmar, C. Siegel, Z. Lin, M. Jeers, D. Abu-Amara, E. Laska
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)