Review
Microbiology
Tiago Bertola Lobato, Matheus Gennari-Felipe, Janaina Ribeiro Barbosa Pauferro, Ilana Souza Correa, Beatriz Ferreira Santos, Beatriz Belmiro Dias, Joao Carlos de Oliveira Borges, Camila Soares dos Santos, Elvirah Samantha de Sousa Santos, Maria Janaina Leite de Araujo, Liliane Araujo Ferreira, Sara Araujo Pereira, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Leandro Borges, Maria Fernanda Cury-Boaventura, Marco Aurelio Ramirez Vinolo, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Rui Curi, Sandro Massao Hirabara, Renata Gorjao
Summary: This review explores the impact of obesity and type 2 diabetes on metabolic changes in leukocytes during SARS-CoV-2 infection, and highlights that obese and diabetic patients are at higher risk of worse prognosis, possibly due to the occurrence of cytokine storms.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kun Wang, Xin Wang, Jiangdong Du, Chunling Liu, Yanan Jiang, Heqiu Zhang, Haiming Jiang, Qiang Fu
Summary: The study found that NLR has predictive value for predicting the severity of COVID-19, and there is a significant positive correlation between NLR and PCT in severe patients.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Immunology
Hanieh Radkhah, Ensieh Sadat Mansouri, Shiva Rahimipour Anaraki, Milad Gholizadeh Mesgarha, Ali Sheikhy, Mohamad Mehdi Khadembashiri, Mohamad Amin Khadembashiri, Mohamad Eslami, Tara Mahmoodi, Behnaz Inanloo, Arash Pour Mohammad
Summary: This study investigated the applicability of hematological indices in predicting the incidence and severity of pulmonary thromboembolism (PTE) in patients with SARS-CoV-2. The findings suggest that higher platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte (NLR) ratios are associated with a greater likelihood of PTE incidence. PLR is an independent predictor of PTE, and a higher neutrophil count is associated with a higher severity of PTE in COVID-19 patients.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Chaoyang Hua, Jia Li, Yanfang Yang, Zhangsuo Liu
Summary: This study aimed to identify the clinical characteristics and risk factors for critical illness in hospitalized COVID-19 patients. The results showed that leucocytes, PLR, NLR, AST, and ALB were independent predictive factors for poor outcomes. The combination of these factors had a high predictive value, particularly in low-resource countries.
EUROPEAN JOURNAL OF INFLAMMATION
(2022)
Review
Critical Care Medicine
Soumya Sarkar, Puneet Khanna, Akhil Kant Singh
Summary: This study systematically analyzed the utility of baseline NLR as a predictive tool for mortality and disease severity in COVID-19 patients, finding that elevated NLR on admission is associated with poor outcomes, indicating significant predictive value for disease severity and mortality in COVID-19 patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Medical Laboratory Technology
Nisa Cetin Kargin
Summary: This study found that serum neutrophil, NLR, and ferritin levels were found to be higher in current smokers/ex-smokers, indicating a poor prognosis of COVID-19 associated with smoking.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Immunology
Ellen McKenna, Richard Wubben, Johana M. Isaza-Correa, Ashanty M. Melo, Aisling Ui Mhaonaigh, Niall Conlon, James S. O'Donnell, Cliona Ni Cheallaigh, Tim Hurley, Nigel J. Stevenson, Mark A. Little, Eleanor J. Molloy
Summary: This article discusses the immunological characteristics of severe COVID-19 patients, the antiviral and pathological roles of neutrophils in SARS-CoV-2 infection, the contribution of neutrophils to complications of COVID-19, and potential therapeutic strategies targeting neutrophil-mediated inflammatory responses in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Emanuel Moisa, Dan Corneci, Mihai Ionut Negutu, Cristina Raluca Filimon, Andreea Serbu, Mihai Popescu, Silvius Negoita, Ioana Marina Grintescu
Summary: In a retrospective study, the newly developed COVID-SOFA score outperformed the traditional SOFA score in predicting 28-day mortality for patients with COVID-19 requiring ICU treatment, showing improved accuracy and suitability for repeated measurements after 48 hours.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Yingzheng Tan, Juan Zhou, Qing Zhou, Lingli Hu, Yunzhu Long
Summary: This retrospective analysis on peripheral blood indicators of COVID-19 patients found that decreased eosinophils may be a sensitive marker for diagnosis and play a crucial role in assessing prognosis, similar to lymphocytes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Huan Yang, Yuan Xu, Zhijie Li, Ling Yan, Jing Wang, Pu Liao
Summary: This study analyzed the clinical characteristics of COVID-19 patients in Chongqing, identifying differences in lymphocyte and neutrophil levels between severe and non-severe groups. The study also found dynamic changes in blood routine analyzing items at different stages of illness, with potential for distinguishing severe cases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
G. M. Parra-Bracamonte, N. Lopez-Villalobos, M. A. Velazquez, F. E. Parra-Bracamonte, A. L. Perales-Torres, K. J. Juarez Rendon
Summary: The purpose of this study was to compare case fatality rates (CFRs) and odds for mortality by risk factors of patients with COVID-19 in Mexico, before, during and after the implementation of the national COVID-19 vaccination programme. The results showed statistically significant differences in CFR and odds ratio in the studied years, favoring the post-vaccination period. Implementation of the COVID-19 vaccination programme during 2021 showed positive consequences on CFR, but the increased odds of dying in hospitalized patients are likely to be due to the unvaccinated proportion of patients.
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Emergency Medicine
Murat Seyit, Esin Avci, Rukiye Nar, Hande Senol, Atakan Yilmaz, Mert Ozen, Alten Oskay, Hulya Aybek
Summary: The study revealed that levels of CRP, LDH, PLR, and NLR were significantly higher in COVID-19 positive patients, while levels of eosinophil, lymphocyte, and platelets were significantly elevated in COVID-19 negative patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)