Metal‐Free Oxidative [5+1] Cyclization of 1,5‐Enynes for the Synthesis of Pyrazine 1‐Oxide

Synthesis of Functionalized Cyclobutane-Fused Naphthalene Derivatives via Cascade Reactions of Allenynes with tert-Butyl Nitrite

(2019) Tian Feng et al.   ADVANCED SYNTHESIS & CATALYSIS

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes

(2019) Logan A. Combee et al.   ORGANIC LETTERS

Metal-Free Synthesis of 2-Fluoroalkylated Quinolines Using Polyfluoroalkanoic Acids as Direct Fluorine Sources

(2019) Jiang Nan et al.   ORGANIC LETTERS

Metal‐Free Oxidative Annulation/Cyclization of 1,6‐Enynes for the Synthesis of 4‐Carbonylquinolines

(2019) Xiao‐Feng Xia et al.   ADVANCED SYNTHESIS & CATALYSIS

Dual Roles of tert‐Butyl Nitrite in the Transition Metal‐ and External Oxidant‐Free Trifluoromethyloximation of Alkenes

(2019) Ya Wu et al.   ChemSusChem

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

(2018) Kenji Nakahara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rhodium(III)-Catalyzed Cascade [5 + 1] Annulation/5-exo-Cyclization Initiated by C–H Activation: 1,6-Diynes as One-Carbon Reaction Partners

(2018) Fen Xu et al.   ORGANIC LETTERS

Chemoselective Nitrosylation of Anilines and Alkynes via Fragmentary or Complete NO Incorporation

(2018) Jun Pan et al.   Chem

Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C−H Bond Amination of N-Aryl Enamines

(2018) Yan-Xiao JIAO et al.   ADVANCED SYNTHESIS & CATALYSIS

tert- Butyl Nitrite Mediated Different Functionalizations of Internal Alkenes: Paths to Furoxans and Nitroalkenes

(2018) Bilal Ahmad Mir et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Reductive [5+1] Cycloaddition of 3-Acetoxy-1,4-enynes with CO: Access to Phenols Enabled by Hydrosilanes

(2018) Li-Jun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective [5 + 1] and [5 + 2] Cycloaddition of Ynamides or Propargyl Esters with Benzo[d]isoxazoles via Gold Catalysis

(2018) Wei Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Nitrative Cyclization of 1,6-Enynes with t-BuONO under Metal-Free Conditions

(2018) Wen-Ting Wei et al.   ACS Sustainable Chemistry & Engineering

Highly selective sp3 C–N bond activation of tertiary anilines modulated by steric and thermodynamic factors

(2017) Xiaodong Jia et al.   GREEN CHEMISTRY

Base-mediated tandem sulfonylation and oximation of alkenes in water

(2017) Bin Wang et al.   GREEN CHEMISTRY

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

(2017) Kai Qiao et al.   GREEN CHEMISTRY

FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity

(2017) K. Shiva Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ag-Catalyzed Oxidative Cyclization Reaction of 1,6-Enynes and Sodium Sulfinate: Access to Sulfonylated Benzofurans

(2017) Wanqing Wu et al.   ORGANIC LETTERS

Short and Safe Synthesis of Ethyl 3-(Trifluoromethyl)pyrazine-2-carboxylate

(2017) Florencio Zaragoza et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Copper-Mediated 1,2-Difunctionalization of Styrenes with Sodium Arylsulfinates andtert-Butyl Nitrite: Facile Access to α-Sulfonylethanone Oximes

(2016) Ji Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

(2016) James D. Osborne et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Concise Total Synthesis of (−)-Mesembrine

(2016) Lu-Ning Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

AgNO2 as the NO Source for the Synthesis of Substituted Pyrazole N-Oxides from N-Propargylamines

(2016) Bingxiang Yuan et al.   ORGANIC LETTERS

Cobalt(III)-Catalyzed [5 + 1] Annulation for 2H-Chromenes Synthesis via Vinylic C–H Activation and Intramolecular Nucleophilic Addition

(2016) Ramajayam Kuppusamy et al.   ACS Catalysis

Nitrative Cyclization of 1-Ethynyl-2-(vinyloxy)benzenes to Access 1-[2-(Nitromethyl)benzofuran-3-yl] Ketones Through Dioxygen Activation

(2015) Ming Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Metal-free nitro-carbocyclization of 1,6-enynes with tBuONO and TEMPO

(2015) Xin-Hua Hao et al.   CHEMICAL COMMUNICATIONS

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

(2015) Yong-Kang Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

(2015) Raphaël Rahmani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Base-Catalyzed Selective Synthesis of 2-Azabicyclo[3.2.0]hept-2-enes and Sulfonyl Vinyl-Substituted Pyrroles from 3-Aza-1,5-enynes

(2015) Xiaoyi Xin et al.   ORGANIC LETTERS

Dehydrogenative N-Incorporation: A Direct Approach to QuinoxalineN-Oxides under Mild Conditions

(2014) Feng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cascade Nitration/Cyclization of 1,7-Enynes withtBuONO and H2O: One-Pot Self-Assembly of Pyrrolo[4,3,2-de]quinolinones

(2014) Yu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ-Lactones

(2014) Shuai Zhao et al.   ORGANIC LETTERS

Hypervalent iodine(iii)-induced oxidative [4+2] annulation of o-phenylenediamines and electron-deficient alkynes: direct synthesis of quinoxalines from alkyne substrates under metal-free conditions

(2013) Sota Okumura et al.   CHEMICAL COMMUNICATIONS

Cyclization and N-Iodosuccinimide-Induced Electrophilic Iodocyclization of 3-Aza-1,5-enynes To Synthesize 1,2-Dihydropyridines and 3-Iodo-1,2-dihydropyridines

(2013) Xiaoyi Xin et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Tandem Annulation and (5 + 1) Cycloaddition: 3-Hydroxy-1,4-enyne as the 5-Carbon Component

(2013) Xiaoxun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Polyfluoroalkyl Cyclobutenes from 3-Aza-1,5-enynes via an Aza-Claisen Rearrangement/Cyclization Cascade

(2013) Xiaoyi Xin et al.   ORGANIC LETTERS

Highly Regioselective Migration of the Sulfonyl Group: Easy Access to Functionalized Pyrroles

(2012) Xiaoyi Xin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu(I)-Catalyzed Synthesis of Imidazo[1,2-a]pyridines from Aminopyridines and Nitroolefins Using Air as the Oxidant

(2012) Ru-Long Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Carbonylation of Cyclopropyl Substituted Propargyl Esters: A Tandem 1,3-Acyloxy Migration [5 + 1] Cycloaddition

(2012) Dongxu Shu et al.   JOURNAL OF ORGANIC CHEMISTRY

Rh(I)-Catalyzed [5 + 1] Cycloaddition of Vinylcyclopropanes and CO for the Synthesis of α,β- and β,γ-Cyclohexenones

(2012) Guo-Jie Jiang et al.   ORGANIC LETTERS

Synthesis of Functionalized Cyclohexenone Core of Welwitindolinones via Rhodium-Catalyzed [5 + 1] Cycloaddition

(2012) Min Zhang et al.   ORGANIC LETTERS

Copper-Mediated Aerobic Synthesis of 3-Azabicyclo[3.1.0]hex-2-enes and 4-Carbonylpyrroles fromN-Allyl/Propargyl Enamine Carboxylates

(2011) Kah Kah Toh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition

(2010) Dongxu Shu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu (I)-Catalyzed Synthesis of Polysubstituted Pyrroles from Dialkyl Ethylenedicarboxylates and β-Enamino Ketones or Esters in the Presence of O2

(2010) Ru-Long Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Reactions between Grignard reagents and heterocyclic N-oxides: Stereoselective synthesis of substituted pyridines, piperidines, and piperazines

(2010) Hans Andersson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fused-Ring Pyrazine Derivatives for n-Type Field-Effect Transistors

(2009) Haifeng Wang et al.   ACS Applied Materials & Interfaces

Synthesis of Pyrroles by Gold(I)-Catalyzed Amino−Claisen Rearrangement ofN-Propargyl Enaminone Derivatives

(2009) Akio Saito et al.   ORGANIC LETTERS

N-Propargylic β-Enaminones: Common Intermediates for the Synthesis of Polysubstituted Pyrroles and Pyridines

(2008) Sandro Cacchi et al.   ORGANIC LETTERS