Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 35, Pages 39685-39694Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c12355
Keywords
hydrogel; biofilms; bacterial infections; diagnostic; phototherapy
Funding
- National Natural Science Foundation of China [21807067, 21977065]
- Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi [2017-07]
- SanJin Scholars Support Plan under Special Fund [2017-06]
- Youth Science Foundation of Shanxi Province [201801D121065]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [201802106, 2019L0022]
- Shanxi Key Laboratory of Functional Molecules
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Diseases induced by bacterial infections increasingly threaten the health of people all over the world; thus, it is urgent and significant to early diagnose and effectively eliminate infections to save people's lives. To this end, we synthesized an intelligent hydrogel that integrated in situ visualized diagnosis and photothermal therapy of bacterial infections. By simply and subtly incorporating pH-sensitive bromothymol blue (BTB) and near-infrared (NIR)-absorbing conjugated polymer (termed as PTDBD) into thermosensitive chitosan (CS)-based hydrogel, the synthesized BTB/PTDBD/CS hydrogel can diagnose the acidic microenvironment of Staphylococcus aureus (S. aureus) biofilm and infected wounds by showing visualized color change. After rapid diagnosis, the hydrogel can immediately treat the infection site by local hyperthermia under irradiation of NIR laser (808 nm) and even the stubborn biofilm that is difficult to eradicate. Since the dominating antibacterial mechanism is hyperthermia, the hybrid hydrogel shows broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and drug-resistant bacteria. In addition, it has low cytotoxicity to normal cells and no effect on the main organs of mice. It paves a brand new avenue to develop smart and facile diagnosis and a treatment platform for bacterial infections.
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