Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 33, Pages 36928-36937Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c09969
Keywords
stellate exosome; biomimetic; plasmonic gold nanostar; targeted NIR-II thermo-radiotherapy; hypoxic tumor
Funding
- National Science Foundation of China [81901882, 31871005, 31900981]
- Chinese Academy of Sciences [YJ-KYYQ20180048]
- China Postdoctoral Science Foundation [2019M663062]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2019093]
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Multifunctional gold (Au)-based nanomaterials with high atomic number (symbol Z) and strong absorbance in the second near-infrared window (NIR-II) property are emerging C as promising candidates for tumor thermo-radiotherapy. The main limitations of applying Au-based nanomaterials to biomedical studies include the absence of active tumor-targeting ability, penetrating efficiency, and stability. In this study, we present a novel type of tumor cell-derived stellate plasmonic exosomes (TDSP-Exos) for penetrative targeted tumor NIR-II thermoradiotherapy and photoacoustic imaging. The TDSP-Exos are abundantly and easily produced by the incubation of tumor cells with gold nanostars, based on which gold nanostars promote the exocytosis of exosomes from tumor cells. Compared with bare gold nanostars, the TDSP-Exos exhibit pronounced accumulation in deep tumor tissues and perform well in both PA imaging and NIR-II thermo-radiotherapy against the tumor. Moreover, the TDSP-Exos improve tumor hypoxia to enhanced radiotherapy by NIR-II photothermal therapy. This work indicates that the tumor cell-derived exosomes have the potential to function as a universal carrier of photothermal agents for targeted tumor NIR-II thermo-radiotherapy.
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