Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Bingyan Cao, Meijuan Liu, Qipeng Luo, Qiao Wang, Min Liu, Xuejun Liang, Di Wu, Wenjing Li, Chang Su, Jiajia Chen, Chunxiu Gong
Summary: This study investigated the associations between serum bone turnover marker (BTM) levels and body mass index (BMI) in Chinese children and adolescents, and found that the influence of BMI, age, and pubertal stage on BTMs varied by gender.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Article
Endocrinology & Metabolism
Xin-ping Li, Xiao-yu Li, Ming-hui Yang, Shi-wen Zhu, Xin-bao Wu, Ping Zhang
Summary: The study found that bone turnover markers peak 30-60 days after surgery, with P1NP showing less than 4 times elevation and CTX and OC rising less than 2 times. Females had higher levels of CTX and OC compared to males, and intertrochanteric fracture patients treated with intramedullary nailing had higher P1NP levels than femoral neck fracture patients undergoing hip replacement. 25(OH)D levels did not impact BTMs, and older patients aged 85 and above showed early decreases in OC levels during fracture healing.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kaisa K. Ivaska, Fiona E. McGuigan, Linnea Malmgren, Paul Gerdhem, Helena Johansson, John A. Kanis, Kristina E. Akesson
Summary: This study found that CTX, urinary OC, and TRAcP5b are predictive for fracture risk within 1 to 3 years, but are less valuable in the long term or in individuals above the age of 80.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei Zhang, Wei Zhao, Wei Li, Qi Geng, Rui Zhao, Yungui Yang, Luyan Lv, Weiwen Chen
Summary: Osteoporosis is a debilitating disease that is often overlooked and poorly studied in elderly male patients. This study aims to investigate molecular alterations in immune cells in men with osteoporosis and identify potential immunomodulatory strategies for treatment. The results show that there are molecular changes in immune cells of male osteoporotic patients and suggest potential therapeutic value of immunomodulation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Sug Hun Che, Myung-Rae Cho, Patrick Michael Quinn, Suk-Kyoon Song
Summary: This study aimed to identify risk factors for hip fractures in elderly Korean patients, especially in patients with osteoporosis. The retrospective analysis of 168 patients showed that lower body weight, BMI, and BMD Z-scores were associated with a higher incidence of intertrochanteric fractures compared to femoral neck fractures. This suggests that there is a correlation between low body weight, BMI, and BMD Z-scores and an increased risk of intertrochanteric fractures in elderly Korean patients.
Article
Nutrition & Dietetics
Elizabeth M. Curtis, Camille Parsons, Kate Maslin, Stefania D'Angelo, Rebecca J. Moon, Sarah R. Crozier, Fatma Gossiel, Nicholas J. Bishop, Stephen H. Kennedy, Aris T. Papageorghiou, Robert Fraser, Saurabh Gandhi, Ann Prentice, Hazel M. Inskip, Keith M. Godfrey, Inez Schoenmakers, M. Kassim Javaid, Richard Eastell, Cyrus Cooper, Nicholas C. Harvey
Summary: This study investigated the changes of maternal bone resorption marker, urinary CTX, across pregnancy, the impact of gestational vitamin D supplementation, and the associations between CTX and maternal postnatal bone outcomes. The results showed that maternal CTX levels increased through pregnancy, with a lesser degree of increase in the cholecalciferol supplementation group, and higher CTX levels at 34 weeks of gestation were associated with lower maternal bone mass postpartum.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Hao-long Zhou, Mu-hong Wei, Dong-sheng Di, Ru-yi Zhang, Jian-li Zhang, Ting-ting Yuan, Qian Liu, Ting-ting Zhou, Qin Huang, Qi Wang
Summary: This study found that genetic variants in NRP1 and PLXNA2 genes are associated with osteoporosis risk and bone mineral density. The NRP1 rs180868035 variant affects bone metabolism by influencing the function of osteoblasts and osteoclasts.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Nekoo Panahi, Afshin Ostovar, Noushin Fahimfar, Hamid Reza Aghaei Meybodi, Safoora Gharibzadeh, Babak Arjmand, Mahnaz Sanjari, Kazem Khalagi, Ramin Heshmat, Iraj Nabipour, Akbar Soltani, Bagher Larijani
Summary: This study aimed to identify factors associated with worse TBS than BMD in non-osteoporotic elderly individuals. The results showed that higher waist circumference was significantly associated with more degraded TBS in both men and women. Years since menopause and current smoking were also associated with worse TBS, indicating the importance of considering these factors in assessing bone health.
Review
Endocrinology & Metabolism
Elena Tsourdi, M. Carola Zillikens, Christian Meier, Jean-Jacques Body, Elena Gonzalez Rodriguez, Athanasios D. Anastasilakis, Bo Abrahamsen, Eugene McCloskey, Lorenz C. Hofbauer, Nuria Guanabens, Barbara Obermayer-Pietsch, Stuart H. Ralston, Richard Eastell, Jessica Pepe, Andrea Palermo, Bente Langdahl
Summary: Discontinuation of denosumab results in increased bone turnover, rapid bone loss, and risk of multiple vertebral fractures in some patients. Prior bisphosphonate therapy or subsequent antiresorptive treatment may help mitigate the biochemical rebound phenomenon after denosumab discontinuation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)