Article
Psychology, Developmental
Denisse Janvier, Yeo Bi Choi, Claire Klein, Catherine Lord, So Hyun Kim
Summary: This study investigated the test-retest reliability of the Calibrated Severity Score (CSS) of the Autism Diagnostic Observation Schedule-2 (ADOS-2) across different modules and found strong reliability for quantifying autism symptom severity. The results support the use of ADOS CSS as a reliable tool for assessing autism symptom severity across development.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychology, Developmental
Melody R. Altschuler, Susan Faja
Summary: The study found varying levels of test-retest reliability for different types of ToM tasks, with most measures showing moderate reliability. The results provide guidance for future intervention work and emphasize the importance of measuring affective ToM.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Genetics & Heredity
Pilar Garces, Sarah Baumeister, Luke Mason, Christopher H. Chatham, Stefan Holiga, Juergen Dukart, Emily J. H. Jones, Tobias Banaschewski, Simon Baron-Cohen, Sven Bolte, Jan K. Buitelaar, Sarah Durston, Bob Oranje, Antonio M. Persico, Christian F. Beckmann, Thomas Bougeron, Flavio Dell'Acqua, Christine Ecker, Carolin Moessnang, Tony Charman, Julian Tillmann, Declan G. M. Murphy, Mark Johnson, Eva Loth, Daniel Brandeis, Joerg F. Hipp
Summary: This study aimed to investigate the differences in resting-state EEG between individuals with autism spectrum disorder (ASD) and neurotypicals (NT), but the results are inconsistent, indicating the need for larger studies to further validate these findings.
Article
Chemistry, Multidisciplinary
Zsofia Borsos, Zoltan Jakab, Krisztina Stefanik, Bianka Bogdan, Miklos Gyori
Summary: This study examines the test-retest reliability of automated emotional facial expression analysis systems and finds that while the reliability is high, it is not perfect. Repeat analyses can improve the stability of emotion intensity datasets. The study suggests further exploration of the test-retest reliability of these systems.
APPLIED SCIENCES-BASEL
(2022)
Article
Pediatrics
Vinod Sharma, Arushi Gahlot Saini, Prahbhjot Malhi, Pratibha Singhi
Summary: The study found that about one-fourth of children with autism spectrum disorders also have epilepsy, with female gender and adverse perinatal events being independent risk factors. Subclinical or isolated EEG abnormalities are associated with abnormal neurological examination.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Neurosciences
Judith Goris, Senne Braem, Shauni Van Herck, Jonas Simoens, Eliane Deschrijver, Jan R. Wiersema, Bryan Paton, Marcel Brass, Juanita Todd
Summary: Findings suggest that individuals with autism exhibit faster model updating during early sensory processing, resulting in less influence from the initial context.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Jennifer H. Foss-Feig, Sylvia B. Guillory, Brian J. Roach, Eva Velthorst, Holly Hamilton, Peter Bachman, Aysenil Belger, Ricardo Carrion, Erica Duncan, Jason Johannesen, Gregory A. Light, Margaret Niznikiewicz, Jean M. Addington, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara Cornblatt, Thomas McGlashan, Diana Perkins, Larry J. Seidman, William S. Stone, Ming Tsuang, Elaine F. Walker, Scott Woods, Carrie E. Bearden, Daniel H. Mathalon
Summary: Psychosis rates are higher in individuals with autism spectrum disorder (ASD) compared to the general population. The study suggests that the sensitivity of P300 to psychosis risk may differ in ASD+ CHR individuals.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Engineering, Biomedical
Xuewei Qin, Lizhao Du, Xiong Jiao, Jingyi Wang, Shanbao Tong, Tifei Yuan, Junfeng Sun
Summary: The study aimed to quantitatively evaluate source localization methods under real situations. Using EEG data from 16 subjects performing face recognition tasks, the source signals were reconstructed and evaluated by five mainstream methods. The results showed promising peak localization reliability and good to excellent test-retest reliability of source amplitude. These findings provide new evidence for the validity of source localization analysis and a new perspective for the evaluation of source localization methods on real EEG data.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Habib Adabi Ardakani, Maryam Taghizadeh, Farzaneh Shayegh
Summary: This paper presents a method for diagnosing autism based on EEG signal analysis. By dividing the signals from individuals with autism and healthy individuals into images and using a 2D-DCNN for classification, high accuracy in diagnosis is achieved. To address the issue of limited data, an image mixing method is used for data augmentation.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Orthopedics
Sara Kardor, Zahra Gorji, Nastaran Ghotbi, Behrouz Attarbashi-Moghadam, Azadeh Shadmehr, Mona Gorji
Summary: This study aimed to assess the relative and absolute test-retest reliability of upper limb power and stability tests in female overhead athletes. The results showed that these tests have acceptable reliability in this population.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Summary: This study aimed to evaluate the behavioral patterns of children with ASD during and after the COVID-19 lockdown, and found that support in the areas of problematic behavior could mitigate future risks.
SCIENTIFIC REPORTS
(2021)
Review
Psychology, Biological
Michaela Herzog, Josef Sucec, Valentina Jelincic, Ilse Van Diest, Omer Van den Bergh, Pei-Ying S. Chan, Paul Davenport, Andreas von Leupoldt
Summary: The study demonstrated that the RREP components Nf, P1, N1, P2, and P3 show adequate reliability in test-retest studies, both with or without induced dyspnea. Nf and P1 showed moderate reliability, while N1, P2, and P3 showed good to excellent reliability in both conditions.
BIOLOGICAL PSYCHOLOGY
(2021)
Article
Biology
Berna Ari, Nebras Sobahi, Omer F. Alcin, Abdulkadir Sengur, U. Rajendra Acharya
Summary: This article introduces a new method for automated detection of Autism Spectrum Disorders (ASD), using techniques such as the DP algorithm, sparse coding, and deep CNNs. The results show that this method achieves high accuracy and sensitivity in ASD detection.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Azilee Curl, Emily L. Coderre
Summary: Language processing in individuals with Autism Spectrum Disorder (ASD) is characterized by impairments in semantic processing, with deficits potentially arising in the early stages of semantic processing. Reduced coherence was observed in the ASD group during language stimuli at a left fronto-parietal connection, indicating a unique language processing mechanism in ASD compared to typically developing individuals.
COGNITIVE NEURODYNAMICS
(2022)
Article
Pediatrics
Paloma Martin-Diaz, Maria Carratala-Tejada, Francisco Molina-Rueda, Alicia Cuesta-Gomez
Summary: ASD patients often have motor deficits, but these issues have received less attention than other symptoms. However, the timed up and go test (TUG) could be a useful tool to evaluate motor challenges in individuals with ASD. This study found that the TUG test had good reliability and low measurement errors in children and teenagers with ASD, making it clinically useful for assessing balance and the risk of falls. However, the study had limitations, such as a non-probabilistic sampling method.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Psychology, Clinical
Tessel Bazelmans, Emily J. H. Jones, Sheila Ghods, Sarah Corrigan, Karen Toth, Tony Charman, Sara J. Webb
Summary: In this study, heart rate (HR) and heart rate variability (HRV) were used to measure engagement with social dynamic stimuli in children with autism spectrum disorder (ASD). The results showed that overall HR and HRV did not differ between preschoolers with ASD and typically developing children (TD). However, the ASD group demonstrated a larger increase in HR to later-presented social stimuli, particularly among children with below average verbal and non-verbal skills.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Hannah M. Rea, Roald A. Oien, Frederick Shic, Sara Jane Webb, Allison B. Ratto
Summary: The study compared autistic males and females on the Autism Diagnostic Observation Schedule (ADOS-2) and found that females were less likely to show atypical social-communication behaviors. However, when controlling for overall symptom intensity, no sex differences were observed. This suggests that the diagnostic tool may be less sensitive to female presentations of ASD or that autistic females exhibit fewer or less intense ASD behaviors.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Tawny Tsang, Adam J. Naples, Erin C. Barney, Minhang Xie, Raphael Bernier, Geraldine Dawson, James Dziura, Susan Faja, Shafali Spurling Jeste, James C. McPartland, Charles A. Nelson, Michael Murias, Helen Seow, Catherine Sugar, Sara J. Webb, Frederick Shic, Scott P. Johnson
Summary: This study used a visual exploration paradigm to examine the salience of social stimuli in ASD. The results showed that children with ASD had less attention and fixation on faces compared to typically developing children, and they spent less time looking at each object on average. Attention to the screen and faces correlated positively with social and cognitive skills in the ASD group.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Pradeep Raj Krishnappa Babu, J. Matias Di Martino, Zhuoqing Chang, Sam Perochon, Rachel Aiello, Kimberly L. H. Carpenter, Scott Compton, Naomi Davis, Lauren Franz, Steven Espinosa, Jacqueline Flowers, Geraldine Dawson, Guillermo Sapiro
Summary: Early differences in sensorimotor functioning have been observed in young autistic children and infants who are later diagnosed with autism. Autistic toddlers exhibit more frequent and complex head movements while watching audiovisual stimuli, suggesting differences in their sensorimotor dynamics compared to neurotypical toddlers. Computer vision analysis provides a scalable means of detecting these differences, which may help identify early behaviors associated with autism.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychiatry
Sara Jane Webb, Adam J. Naples, April R. Levin, Gerhard Hellemann, Heather Borland, Jessica Benton, Carter Carlos, Takumi McAllister, Megha Santhosh, Helen Seow, Adham Atyabi, Raphael Bernier, Katarzyna Chawarska, Geraldine Dawson, James Dziura, Susan Faja, Shafali Jeste, Michael Murias, Charles A. Nelson, Maura Sabatos-DeVito, Damla Senturk, Frederick Shic, Catherine A. Sugar, James C. McPartland
Summary: This study evaluated a battery of EEG assays as potential biomarkers for clinical trials in ASD, and found that resting state, faces task, and VEP showed promise in terms of data acquisition and construct performance. The study also observed that the faces task's P1 and N170 performed well in terms of group discrimination and phenotype correlations, providing valuable information for further evaluation of biomarkers.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Matthew M. Engelhard, Ricardo Henao, Samuel I. Berchuck, Junya Chen, Brian Eichner, Darby Herkert, Scott H. Kollins, Andrew Olson, Eliana M. Perrin, Ursula Rogers, Connor Sullivan, YiQin Zhu, Guillermo Sapiro, Geraldine Dawson
Summary: Early detection of autism in childhood is crucial for providing early behavioral support to autistic children and their families. This study utilized electronic health records to develop predictive models for detecting autism early, resulting in clinically meaningful accuracy by age 30 days and further improvement by age 1 year. The automated approach could be combined with caregiver surveys to enhance the accuracy of early autism screening.
Article
Health Care Sciences & Services
Sam Perochon, J. Matias Di Martino, Kimberly L. H. Carpenter, Scott Compton, Naomi Davis, Steven Espinosa, Lauren Franz, Amber D. Rieder, Connor Sullivan, Guillermo Sapiro, Geraldine Dawson
Summary: Increasing evidence suggests that early motor impairments are common in autism. This study presents a scalable and engaging assessment of visual-motor abilities in young autistic children using a tablet-based bubble-popping game. Results show differences in motor behavior between autistic and neurotypical children, as well as the impact of co-occurring ADHD. These findings highlight the potential of touch-based games as a screening tool for early signs of autism.
NPJ DIGITAL MEDICINE
(2023)
Article
Behavioral Sciences
Marika Coffman, J. Matias Di Martino, Rachel Aiello, Kimberly L. H. Carpenter, Zhuoqing Chang, Scott Compton, Brian Eichner, Steve Espinosa, Jacqueline Flowers, Lauren Franz, Sam Perochon, Pradeep Raj Krishnappa Babu, Guillermo Sapiro, Geraldine Dawson
Summary: Early behavioral markers for autism include differences in social attention and orienting, as well as body movements and motor abilities. This study evaluated the correlation between objective measures of autism-related behaviors obtained from an app (SenseToKnow) and standardized caregiver-report and clinician administered measures. The findings support the validity of the SenseToKnow app in identifying autism-related behaviors and associated clinical profiles.
Article
Psychology, Developmental
Dmitry Yu. Isaev, Maura Sabatos-DeVito, J. Matias Di Martino, Kimberly Carpenter, Rachel Aiello, Scott Compton, Naomi Davis, Lauren Franz, Connor Sullivan, Geraldine Dawson, Guillermo Sapiro
Summary: We analyzed caregiver-child interactions during free play with children diagnosed with autism, ADHD, or combined autism + ADHD, and neurotypical children. The analysis revealed two clusters of interaction patterns, which differed in the frequency of reaching to a toy and caregivers' contingent responses. Higher caregiver responsiveness was associated with less developed language, communication, and socialization skills in children. The clusters were not associated with diagnostic groups, suggesting the potential for automated assessment methods in clinical trials.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Jill Howard, Brianna Herold, Samantha Major, Caroline Leahy, Kevin Ramseur, Lauren Franz, Megan Deaver, Saritha Vermeer, Kimberly L. H. Carpenter, Michael Murias, Wei Angel Huang, Geraldine Dawson
Summary: This study explored the relationship between executive function and attention abilities and social and language skills in early childhood for 180 autistic children. Higher levels of executive function skills were associated with better social communication abilities and lower levels of social pragmatic problems. Children with longer sustained attention showed higher expressive language abilities. These findings highlight the importance of executive function and attention skills in autistic children, particularly in language and social communication.
Article
Psychology, Developmental
Andrew Yuan, Maura Sabatos-DeVito, Alexandra L. Bey, Samantha Major, Kimberly L. H. Carpenter, Lauren Franz, Jill Howard, Saritha Vermeer, Ryan Simmons, Jesse Troy, Geraldine Dawson
Summary: This study investigated whether automated video tracking of autistic children's movement and location during play correlates with clinical features. The results suggest that movement tracking is a promising method for assessing clinical variation during autistic children's play.
Article
Psychology, Developmental
Darby Herkert, Connor Sullivan, YiQin Zhu, Geraldine Dawson
Summary: The American Academy of Pediatrics recommends screening for autism in children at 18 and 24 months. A study found that for the majority of children who screened positive for autism, there were prior concerns related to development or health. This suggests that screening can provide an opportunity for healthcare providers to address autism within the context of existing concerns.
Article
Behavioral Sciences
Zhengyi Gu, Geraldine Dawson, Matthew Engelhard
Summary: This study investigated sex differences in the age of autism diagnosis and their associations with neurodevelopmental, psychiatric, and medical conditions. The results showed that girls were more likely to be diagnosed earlier or later, while boys were more likely to be diagnosed between the ages of 3 and 11. Girls had higher rates of anxiety and mood disorders, while boys had more visits to otolaryngologists. Controlling for these conditions reduced and eliminated the associations between sex and diagnosis age.
Article
Behavioral Sciences
Frederick Shic, Erin C. Barney, Adam J. Naples, Kelsey J. Dommer, Shou An Chang, Beibin Li, Takumi Mcallister, Adham Atyabi, Quan Wang, Raphael Bernier, Geraldine Dawson, James Dziura, Susan Faja, Shafali Spurling Jeste, Michael Murias, Scott P. Johnson, Maura Sabatos-DeVito, Gerhard Helleman, Damla Senturk, Catherine A. Sugar, Sara Jane Webb, James C. Mcpartland, Katarzyna Chawarska
Summary: This study extends the use of the Selective Social Attention task to preschool and school-age children, and demonstrates the differences in socially-specific attentional patterns associated with autism spectrum disorder. The results also suggest that the SSA may have broad potential as a biomarker for autism spectrum disorder.
Article
Psychology, Developmental
Alexandra L. Bey, Maura Sabatos-DeVito, Kimberly L. H. Carpenter, Lauren Franz, Jill Howard, Saritha Vermeer, Ryan Simmons, Jesse D. Troy, Geraldine Dawson
Summary: In this exploratory study, automated video tracking was used to measure the patterns of movement in 159 autistic children aged 2 to 7 during play-based interactions with their caregivers. Results showed that children with higher durations and velocity of movement were younger, had lower cognitive abilities, more severe autism-related features, less attention to their caregivers, and lower levels of joint engagement. Children who remained in close proximity to their caregivers were more likely to engage in joint activities that required support. This suggests that video tracking can be a scalable and quantitative measure of autism-related behaviors.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)