Journal
MICROORGANISMS
Volume 8, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms8060803
Keywords
fungal pathogens; CRISPR; RNAi; genetic tools; animal models
Categories
Funding
- Medical Research Council Centre for Medical Mycology at the University of Exeter [MR/N006364/2]
- Wellcome [101873/Z/13/Z, 200208/A/15/Z]
- University of Exeter
- MRC [MR/N006364/2, MR/N006364/1] Funding Source: UKRI
- Wellcome Trust [101873/Z/13/Z, 200208/A/15/Z] Funding Source: Wellcome Trust
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Pathogenic fungi represent an increasing infectious disease threat to humans, especially with an increasing challenge of antifungal drug resistance. Over the decades, numerous tools have been developed to expedite the study of pathogenicity, initiation of disease, drug resistance and host-pathogen interactions. In this review, we highlight advances that have been made in the use of molecular tools using CRISPR technologies, RNA interference and transposon targeted mutagenesis. We also discuss the use of animal models in modelling disease of human fungal pathogens, focusing on zebrafish, the silkworm,Galleria mellonellaand the murine model.
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