The Resistance Mechanisms of Checkpoint Inhibitors in Solid Tumors

Resistance to Checkpoint Inhibition in Cancer Immunotherapy

(2020) Luisa Barrueto et al.   Translational Oncology

Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents

(2020) Paola Ciciola et al.   Journal of Clinical Medicine

Mechanisms of the Antitumor Activity of Low Molecular Weight Heparins in Pancreatic Adenocarcinomas

(2020) Alexandros Bokas et al.   Cancers

Tumor-Associated Macrophages: Recent Insights and Therapies

(2020) Jiawei Zhou et al.   Frontiers in Oncology

Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice

(2020) Sharmilla Devi Jayasingam et al.   Frontiers in Oncology

Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

(2020) Panagiotis Sarantis et al.   World Journal of Gastrointestinal Oncology

Microbiome and cancer immunotherapy

(2020) Shanmuga Reddy Chilakapati et al.   CURRENT OPINION IN BIOTECHNOLOGY

Autophagy in endothelial cells and tumor angiogenesis

(2019) Marco B. Schaaf et al.   CELL DEATH AND DIFFERENTIATION

Gut microbiome and cancer immunotherapy

(2019) Weina Li et al.   CANCER LETTERS

Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

(2019) Abdullah Al Emran et al.   TRENDS IN IMMUNOLOGY

Patients Selection for Immunotherapy in Solid Tumors: Overcome the Naïve Vision of a Single Biomarker

(2019) Diego Signorelli et al.   Biomed Research International

The Interplay of Autophagy and Tumor Microenvironment in Colorectal Cancer—Ways of Enhancing Immunotherapy Action

(2019) Evangelos Koustas et al.   Cancers

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

(2019) Reem Saleh et al.   SEMINARS IN CANCER BIOLOGY

Complementing the Cancer-Immunity Cycle

(2019) Ruben Pio et al.   Frontiers in Immunology

Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing

(2019) Marine Leclerc et al.   Frontiers in Immunology

A Review of the Role of Wnt in Cancer Immunomodulation

(2019) Whitney N. Goldsberry et al.   Cancers

Wnt Signaling in Cancer Metabolism and Immunity

(2019) Sara El-Sahli et al.   Cancers

MicroRNAs, T-cell immunity and immunotherapy

(2019) Bikash R Giri et al.   Future Medicinal Chemistry

Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer

(2019) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation-Derived Neoantigens for Cancer Immunotherapy

(2019) John C. Castle et al.   Frontiers in Immunology

Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer

(2019) Evangelos Koustas et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial

(2019) Robert J Motzer et al.   LANCET ONCOLOGY

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Mechanisms of Resistance to PD-1 and PD-L1 Blockade

(2018) Theodore S. Nowicki et al.   CANCER JOURNAL

Autophagy in dendritic cells

(2018) Ghita Ghislat et al.   Cellular & Molecular Immunology

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial

(2018) Thomas Powles et al.   LANCET

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

(2018) Kabir A. Khan et al.   Nature Reviews Clinical Oncology

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The gut microbiota and immune checkpoint inhibitors

(2018) Audrey Humphries et al.   Human Vaccines & Immunotherapeutics

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2

(2018) Na Luo et al.   OncoImmunology

Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Role of miRNAs in Immune Responses and Immunotherapy in Cancer

(2018) Maria Angelica Cortez et al.   GENES CHROMOSOMES & CANCER

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The multifaceted role of autophagy in cancer and the microenvironment

(2018) Hendrik Folkerts et al.   MEDICINAL RESEARCH REVIEWS

The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status

(2018) Evangelos Koustas et al.   PLoS One

Upgraded role of autophagy in colorectal carcinomas

(2018) Evangelos Koustas et al.   World Journal of Gastrointestinal Oncology

Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032

(2018) Neal Ready et al.   Journal of Thoracic Oncology

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer

(2018) Neda Yaghoubi et al.   BIOMEDICINE & PHARMACOTHERAPY

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma

(2017) Suzanne George et al.   IMMUNITY

Human regulatory B cells in health and disease: therapeutic potential

(2017) Claudia Mauri et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of antibiotics on outcome in patients with metastatic renal cell carcinoma treated with immune checkpoint inhibitors.

(2017) Lisa Derosa et al.   JOURNAL OF CLINICAL ONCOLOGY

The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses

(2017) Liangshun You et al.   Journal of Hematology & Oncology

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy

(2017) Roberta Mazzone et al.   Clinical Epigenetics

Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models

(2017) William K. Decker et al.   Frontiers in Immunology

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

(2016) Xiaohong Wang et al.   CANCER RESEARCH

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

PD-L1 Expression in Lung Cancer

(2016) Hui Yu et al.   Journal of Thoracic Oncology

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

(2016) Martin Reck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Beyond Intracellular MHC Class II Antigen Presentation

(2016) Christian Münz   TRENDS IN IMMUNOLOGY

nab-Paclitaxel as a potential partner with checkpoint inhibitors in solid tumors

(2016) Hatem Soliman   OncoTargets and Therapy

Immunotherapy and Oncogenic Pathways: The PTEN Connection

(2016) N. A. Rizvi et al.   Cancer Discovery

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma

(2016) Pei-Yu Huang et al.   Oncotarget

Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway

(2016) Meng Zhou et al.   OncoImmunology

Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine

(2016) David B. Page et al.   Journal for ImmunoTherapy of Cancer

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

(2016) Yu-Ling Li et al.   Cancer Biology & Medicine

Differential use of autophagy by primary dendritic cells specialized in cross-presentation

(2015) Justine D Mintern et al.   Autophagy

Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells

(2015) Jichen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+T Cells after Intercellular Antigen Transfer

(2015) Jean Francois Fonteneau et al.   JOURNAL OF IMMUNOLOGY

Mast cells as targets for immunotherapy of solid tumors

(2015) Sharon A. Oldford et al.   MOLECULAR IMMUNOLOGY

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Macroautophagy in Endogenous Processing of Self- and Pathogen-Derived Antigens for MHC Class II Presentation

(2015) Fernanda V. Duraes et al.   Frontiers in Immunology

Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents

(2015) Erika Héninger et al.   Frontiers in Immunology

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Modified Vaccinia Virus Ankara-Infected Dendritic Cells Present CD4+T-Cell Epitopes by Endogenous Major Histocompatibility Complex Class II Presentation Pathways

(2014) Frank Thiele et al.   JOURNAL OF VIROLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34

(2013) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Blocking the interleukin 2 (IL2)-induced systemic autophagic syndrome promotes profound antitumor effects and limits toxicity

(2012) Michael T. Lotze et al.   Autophagy

Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer

(2012) Sandra Salvi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

(2012) Robert M. Samstein et al.   CELL

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

Intersection of autophagy with pathways of antigen presentation

(2012) Natalie L. Patterson et al.   Protein & Cell

Regulation of T Cell Homeostasis and Responses by Pten

(2012) Ryan H. Newton et al.   Frontiers in Immunology

Autophagy and Cancer

(2012) Francesca Aredia et al.   Cells

B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer

(2010) David J. DiLillo et al.   Annals of the New York Academy of Sciences

Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects

(2010) Robin F. J. Benus et al.   BRITISH JOURNAL OF NUTRITION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy and Its Role in MHC-Mediated Antigen Presentation

(2009) V. L. Crotzer et al.   JOURNAL OF IMMUNOLOGY

Different regulation of MHC Class I antigen processing components in human tumors

(2009) Barbara Seliger   Journal of Immunotoxicology

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE