Article
Endocrinology & Metabolism
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, Takumi Era, Koichi Ikuta, Johji Imura, Kunimasa Yagi, Takashi Nakagawa, Shiho Fujisaka, Kazuyuki Tobe
Summary: The expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes is metabolically healthy, particularly in the gonadal white adipose tissue of male mice receiving a high-fat diet. Contrary to previous findings, the inguinal white adipose tissue of male mice also shows a high potential for proliferation and differentiation of adipocyte progenitors, leading to hyperplasia in response to high-fat diet feeding.
MOLECULAR METABOLISM
(2021)
Review
Chemistry, Medicinal
Dharmani Devi Murugan, Dharvind Balan, Pooi-Fong Wong
Summary: Obesity is a serious public health issue, and in addition to lifestyle changes and dietary modifications, pharmacotherapy is considered as an alternative strategy for treatment. Bioactive phytochemicals are being explored as a valuable source for new antiobesity agents, but further research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Hyo-Geun Lee, Yu-An Lu, Jun-Geon Je, Thilina U. Jayawardena, Min-Cheol Kang, Seung-Hong Lee, Tae-Hee Kim, Dae-Sung Lee, Jeong-Min Lee, Mi-Jin Yim, Hyun-Soo Kim, You-Jin Jeon
Summary: The study revealed that ethanol extract from Grateloupia elliptica has a significant inhibitory effect on lipid accumulation, and a chlorophyll derivative with lipid accumulation inhibitory activity was successfully isolated.
Article
Cell Biology
Min Chen, Soochi Kim, Liang Li, Sourav Chattopadhyay, Thomas A. Rando, Brian J. Feldman
Summary: Through single-cell RNA sequencing, a population of CD31- CD45- cells with a specific expression profile is discovered in the stromal vascular fraction of adipose tissue. This population is placed on an epistatic pathway upstream of preadipocytes and functional properties with broad implications, including physiological mechanisms regulating adipogenesis, are revealed.
Article
Biochemistry & Molecular Biology
Qianfen Wan, Carmen Calhoun, Tarik Zahr, Li Qiang
Summary: Obesity is caused by the expansion of adipose tissue, which regulates energy balance, adipokine secretion, thermogenesis, and inflammation. Adipocytes are traditionally believed to store lipids through lipid synthesis, but they can still function and respond to nutrients even when depleted of lipid droplets. This raises the question of whether lipid synthesis and storage can be separated from adipocyte development and function.
Review
Nutrition & Dietetics
Oleksandra Liudvytska, Joanna Kolodziejczyk-Czepas
Summary: This article reviews the potential of edible and ethnomedicinal rhubarb species as anti-obesity agents and highlights the emerging role of rhubarb-derived extracts or individual compounds in obesity prevention and treatment. The research focuses on popular edible rhubarb specimens, such as garden rhubarb and Siberian rhubarb, while also presenting the anti-obesity potential of other rhubarb species. The significance of rhubarb-derived extracts and specialized rhubarb metabolites, including anthraquinones and stilbenes, as potential modulators of human metabolism is emphasized.
Article
Biochemistry & Molecular Biology
Hee Jung Kim, Yoon Seo Jang, Ji Won Ha, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Kyunga Kim, Ki Hyun Kim, Sung Hee Um
Summary: The compounds isolated from Salix pseudolasiogyne twigs, oregonin and 2'-O-acetylsalicortin, were found to exhibit anti-adipogenic effects, with the latter significantly suppressing lipid accumulation at a concentration of 50 μM. These compounds have the potential to be used as therapeutic agents to effectively control adipocyte differentiation, a critical stage in the progression of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Gildardo Gembe-Olivarez, Maria Elizabeth Preciado-Ortiz, Wendy Campos-Perez, Sarai Citlalic Rodriguez-Reyes, Erika Martinez-Lopez, Juan Jose Rivera-Valdes
Summary: The prevalence of obesity has been rapidly increasing worldwide. Ginger has an anti-obesogenic effect due to its high content of gingerols. This study demonstrates the anti-adipogenic and lipolytic effects of the main bioactive compounds found in ginger, providing a basis for further in vivo studies and clinical trials.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Physiology
Peng-Peng Zhang, Qiu Han, Ming-Xuan Sheng, Chun-Yu Du, Ya-Ling Wang, Xiao-Fang Cheng, Hai-Xia Xu, Cen-Cen Li, Yong-Jie Xu
Summary: The study identified a large number of circRNAs expressed in white adipogenesis, with differentially expressed circRNAs potentially playing important roles in regulating adipogenesis and many circRNAs potentially facilitating regulatory functions by acting as miRNA sponges.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jasmine A. Burrell, Jacqueline M. Stephens
Summary: KAT8 is essential for adipocyte differentiation, with its loss inhibiting the formation of adipocytes in the early stages. However, its absence does not significantly impact later stages of adipocyte differentiation. Further studies are needed to determine the specific functions and regulation of KAT8 in adipose tissue.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Endocrinology & Metabolism
Tammy Ying, Rebecca A. Simmons
Summary: Understanding the development of adipocyte precursors is crucial for preventing obesity-related diseases. Recent studies using new techniques to analyze adipocyte precursors have revealed insights into their lineages and regulatory mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Ursula White
Summary: White adipose tissue (WAT) expansion plays a crucial role in metabolic health, and impaired WAT expansion can lead to metabolic disorders. While increased hyperplasia is considered important for healthy WAT expansion, the role of adipogenesis remains debated. This mini-review will summarize recent developments and highlight the significance of WAT expansion in obesity and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Pengpeng Zhang, Mingxuan Sheng, Chunyu Du, Zhe Chao, Haixia Xu, Xiaofang Cheng, Cencen Li, Yongjie Xu
Summary: This study identified 3,869 circRNAs during brown adipogenesis and found that 117 of them showed differential expression. Functional analysis suggested that circRNAs may act as microRNA sponges. These findings provide novel insights into the regulatory roles of circRNAs in brown adipogenesis.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Jessica L. Nicholson, Pamela Toh, Naghum Alfulaij, Marla J. Berry, Daniel J. Torres
Summary: It has been 50 years since the discovery of the first selenoprotein, and our understanding of the importance of selenium has greatly increased. We now know that the brain relies on selenium for proper functioning, and a lack of certain selenoproteins can lead to neurodegeneration. Additionally, selenoprotein-mediated redox balance has been found to affect neuronal activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jo Woon Seok, Jae Yeo Park, Hyun Ki Park, Hyangkyu Lee
Summary: Endrin is the most potent obesogen that enhances adipogenesis and promotes early-stage adipogenic differentiation through mTOR pathway activation.
Review
Nutrition & Dietetics
Tommaso Filippini, Susan Fairweather-Tait, Marco Vinceti
Summary: This systematic review and meta-analysis on the effects of selenium supplementation on immune function in healthy people concludes that the overall impact is inconsistent and heterogeneous. The evidence does not support the need to supplement selenium beyond the recommended dietary intake for beneficial effects on immune function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Environmental Sciences
Federica Veneri, Marco Vinceti, Luigi Generali, Maria Edvige Giannone, Elena Mazzoleni, Linda S. Birnbaum, Ugo Consolo, Tommaso Filippini
Summary: A systematic review and meta-analysis was conducted to explore the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The majority of studies suggested an adverse effect, especially at low levels of exposure, but the role of confounding factors needs to be further investigated.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Marcella Malavolti, Carlotta Malagoli, Tommaso Filippini, Lauren A. Wise, Alessio Bellelli, Giovanni Palazzi, Monica Cellini, Sofia Costanzini, Sergio Teggi, Marco Vinceti
Summary: A case-control study found that living close to a petrol station, especially one with more frequent refueling activity, was associated with an increased risk of childhood leukemia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Teresa Urbano, Tommaso Filippini, Lauren A. Wise, Sabrina Sucato, Elisa Polledri, Marcella Malavolti, Silvia Fustinoni, Bernhard Michalke, Marco Vinceti
Summary: This study assessed the association between selenium status and urinary 8-oxodG concentrations in a Northern Italian population and found that this association varied by sex, with background exposure to selenium species positively associated with oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schuz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer
Summary: The study explores the associations between nonchromosomal birth defects and childhood leukemia using data from the Childhood Cancer and Leukemia International Consortium. The results suggest possible novel genetic and environmental factors associated with birth defects that may also increase leukemia susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Applied
Agostino Passafiume, Andrea Rossetti, Luciano Vescovi, Marcella Malavolti, Claudia Baraldi, Sergio Rovesti, Marco Vinceti, Tommaso Filippini
Summary: This study investigated the dietary patterns and sulfur intake in 719 Italian adults. It found that the highest sulfur content was in preserved/canned fish, seafood, white meat, and dairy products, while fresh fruit, oils and fats, and beverages had the lowest sulfur content. The average sulfur intake in the population was 1.1 g/day, slightly higher in men than women. Adherence to dietary patterns had little influence on sulfur intake, except for adherence to the MIND diet, which was positively associated with sulfur intake.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Tommaso Filippini, Teresa Urbano, Peter Grill, Carlotta Malagoli, Angela Ferrari, Cristina Marchesi, Nicoletta Natalini, Bernhard Michalke, Marco Vinceti
Summary: This study aimed to investigate the relationship between human serum albumin-bound selenium (Se-HSA) and total selenium as well as specific organic and inorganic selenium species. The findings indicated that Se-HSA was positively associated with inorganic selenium species and inversely associated with organic selenium species. Se-HSA incorporated more selenium when circulating levels of inorganic compounds were higher.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Food Science & Technology
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Frank Thies, Sophia Tsabouri, Marco Vinceti, Jean-Louis Bresson, Thibault Fiolet, Alfonso Siani
Summary: In response to an application from Procter & Gamble BV, the panel reviewed the scientific evidence for a health claim regarding the role of choline in normal liver function of the foetus and breastfed infants. Choline plays a crucial role in cell membrane structure, cell signalling, lipid and cholesterol metabolism, and neurotransmitter synthesis. While the human body can synthesize choline, studies have shown that low intake can lead to liver dysfunction and muscle damage, which can be repaired with dietary choline.
Article
Food Science & Technology
Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhauser-Berthold, Morten Poulsen, Yolanda Sanz, Josef Rudolf Schlatter, Henk van Loveren, Wolfgang Gelbmann, Helle Katrine Knutsen
Summary: This article summarizes the opinion on the safety assessment of an apple fruit cell culture biomass as a novel food. The cells are sourced from apple callus and cultivated in a liquid medium. The main components of the novel food are carbohydrates, ash, proteins, and smaller amounts of fatty acids and organic acids. Despite the differences with apple, the Panel concludes that the apple fruit cell culture biomass is safe under the proposed conditions of use.
Article
Food Science & Technology
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karen-Ildico Hirsch-Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Susan Lanham-New, Giovanni Passeri, Ionut Craciun, Lucia Fabiani, Rita Ferreira De Sousa, Laura Martino, Silvia Valtuena Martinez, Androniki Naska
Summary: Following requests from the EC, the EFSA NDA Panel conducted systematic reviews to determine the UL for vitamin D and proposed a CF for calcidiol monohydrate to vitamin D-3 conversion for labeling purposes. Based on the evidence, a CF of 2.5 was proposed for calcidiol monohydrate. European populations are unlikely to exceed the UL, except for regular users of high-dose vitamin D supplements.
Review
Public, Environmental & Occupational Health
Federica Veneri, Inga Iamandii, Marco Vinceti, Linda S. Birnbaum, Luigi Generali, Ugo Consolo, Tommaso Filippini
Summary: In this systematic review and meta-analysis, we examined the relationship between fluoride exposure and skeletal fluorosis (SF) using a novel statistical methodology. Our analysis indicates a significant association between fluoride exposure and SF occurrence, with higher levels of fluoride increasing the risk of developing moderate-severe forms of the disease.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2023)
Review
Medicine, General & Internal
Gianluca Fiore, Federica Veneri, Rosaria Di Lorenzo, Luigi Generali, Marco Vinceti, Tommaso Filippini
Summary: This review investigates the effects of fluoride exposure on attention deficit hyperactivity disorder (ADHD) in children and adolescents. The results suggest that early exposure to fluoride may have neurotoxic effects on neurodevelopment, affecting behavioral, cognitive, and psychosomatic symptoms related to ADHD diagnosis. However, due to the heterogeneity of the included studies, current evidence does not allow for a conclusive confirmation of a specific link between fluoride exposure and ADHD development.
MEDICINA-LITHUANIA
(2023)
Article
Environmental Sciences
Manuela Tondelli, Annalisa Chiari, Giulia Vinceti, Chiara Galli, Simone Salemme, Tommaso Filippini, Chiara Carbone, Claudia Minafra, Claudia De Luca, Riccardo Prandi, Simona Tondelli, Giovanna Zamboni
Summary: This study explores the relationship between greenness and neuropsychiatric symptoms in individuals with dementia. The findings suggest that green environments may have an impact on the mental well-being of people with dementia.
ENVIRONMENTAL RESEARCH
(2024)
Review
Environmental Sciences
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Summary: The objective of this study was to review existing epidemiological and laboratory findings supporting the role of toxic metal exposure in non-alcoholic fatty liver disease (NAFLD). The existing studies demonstrate a link between exposure to cadmium, lead, arsenic, and mercury and an increased risk of NAFLD, as well as altered liver injury markers. Laboratory studies also show that metal exposure leads to hepatic lipid accumulation and affects metabolic pathways and inflammatory response.
ENVIRONMENTAL RESEARCH
(2023)
