Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Aylin Alkan, Tobias Hofving, Eva Angenete, Ulf Yrlid
Summary: Rectal cancer accounts for approximately one-third of all colorectal cancers and has significant mortality globally. Tumour response rates to treatment vary significantly between patients, highlighting the need for treatment stratification. Researchers are working to find new biomarkers for predicting tumour response in rectal cancer.
BIOMARKER RESEARCH
(2021)
Article
Immunology
Magdalena Hagen, Tirtha Chakraborty, William J. Olson, Martin Heitz, Natascha Hermann-Kleiter, Janine Kimpel, Brigitte Jenewein, Johanna Pertoll, Verena Labi, Klaus Rajewsky, Emmanuel Derudder
Summary: B lymphocyte development is a well-ordered process that leads to the formation of mature B cells capable of recognizing a variety of antigens. miRNA regulation plays a crucial role in B cell biology, especially in development and migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolay Mehterov, Boyan Vladimirov, Andrea Sacconi, Claudio Pulito, Marcin Rucinski, Giovanni Blandino, Victoria Sarafian
Summary: miR-30c-5p, when downregulated in saliva, shows potential as a novel non-invasive biomarker for early detection of oral squamous cell carcinoma (OSCC).
Article
Oncology
Xiaoyan Sun, Weiran Liu, Leina Sun, Huilan Mo, Yingnan Feng, Xinyi Wu, Chenguang Li, Chen Chen, Jingjing Li, Ying Xin, Zhenfa Zhang, Changli Wang, Bin Zhang, Dongsheng Yue
Summary: This study investigated the maturation and abundance of tertiary lymphoid structures (TLS) in resectable non-small cell lung cancer (NSCLC) patients receiving neoadjuvant treatments, and found that the maturation of TLS is associated with treatment response and patient prognosis. The neoadjuvant chemoimmunotherapy group showed the highest TLS maturation and abundance, as well as higher rates of major pathological response (MPR) and pathological complete response (pCR). The maturation and abundance of TLS were significantly correlated with MPR and disease-free survival (DFS), and were independent predictors for DFS.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Milosz Pietrus, Michal Seweryn, Przemyslaw Kapusta, Pawel Wolkow, Kazimierz Pitynski, Gracjan Wator
Summary: Endometrial cancer (EC) is treated based on stage and prognostic risk factors. Differences between grades can be distinguished through miRNA profiling, with miR-375 and miR190b being markers that best distinguish high-grade EC from low-grade EC. One possible mechanism for high-grade EC is virus modulation of host morphology or physiology.
Article
Oncology
Xiaofang Xing, Jinyao Shi, Yongning Jia, Yunsheng Dou, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Xiaomei Li, Hong Du, Ying Hu, Shuqin Jia, Jian Zhang, Ziyu Li, Jiafu Ji
Summary: The study provides insights into the immune modulation effect of chemotherapy in gastric cancer, suggesting that the immune profile of specimens after standard chemotherapy should be considered for personalized immunotherapy to improve clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Yumeng Cui, Xiaojie Wu, Jie Jin, Weiling Man, Jie Li, Xiang Li, Yanghua Li, He Yao, Rongbin Zhong, Shiyun Chen, Jiahui Wu, Tianhao Zhu, Yanli Lin, Junjie Xu, Youliang Wang
Summary: In this study, circHERC1 was found to be significantly upregulated in lung cancer tissues and cells, and its ectopic expression promoted proliferation, invasion, and metastasis while inhibiting apoptosis of lung cancer cells both in vitro and in vivo. Mechanistic studies revealed that circHERC1 acted as a competitive endogenous RNA of miR-142-3p to relieve the suppressive effect on its target HMGB1, thus activating the MAPK/ERK and NF-kappa B pathways and promoting migration and invasion. Additionally, circHERC1 was found to sequester FOXO1 in the cytoplasm, regulating AKT activity and BIM transcription, which led to increased cell proliferation and decreased apoptosis.
Article
Multidisciplinary Sciences
Klaudia Klicka, Tomasz M. Grzywa, Alicja Klinke, Aleksandra Mielniczuk, Jaroslaw Wejman, Joanna Ostrowska, Agata Gondek, Pawel K. Wlodarski
Summary: This study aimed to assess the expression levels of 16 miRNAs in endometrial cancer and found aberrant expression profiles in some miRNAs. This research is important for understanding the epigenetic mechanisms and potential development of endometrial cancer.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Shifen Zhang, Na Li, Feifei Wang, Hailing Liu, Yuhan Zhang, Jinyuan Xiao, Weihao Qiu, Ceng Zhang, Xinjuan Fan, Mingxin Qiu, Mingzhou Li, Hongzhen Tang, Shiheng Fan, Jiaqian Wang, Haitao Luo, Xiangzhao Li, Jie Lin, Yan Huang, Li Liang
Summary: Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for locally advanced rectal cancer (LARC), but a significant number of patients show little to no response. This study used digital spatial profiling and immunofluorescence techniques to study tumor biopsy samples from LARC patients. The researchers identified biomarkers in the tumor microenvironment that can potentially predict nCRT efficacy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Erik Kaadt, Kristoffer Hojgaard, Birgitte Mumm, Sofie Laage Christiansen, Heidi Kaastrup Mueller, Christian Kroun Damgaard, Betina Elfving
Summary: Studying microRNAs in the skin of depressed subjects can aid diagnostic efforts, and rat skin is a valid alternative to human fibroblast cultures for validating dysregulated miRNAs. Certain miRNAs appear to be specific biomarkers for the depressive phenotype, showing dysregulation in both human patients and various rat models of depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Oncology
Yirizhati Aili, Nuersimanguli Maimaitiming, Yusufu Mahemuti, Hu Qin, Yongxin Wang, Zengliang Wang
Summary: Gliomas are central nervous system tumors with poor prognosis, where exosomal miRNA plays a significant role in their occurrence, development, invasion, metastasis, and treatment resistance. Further systematic research on the association of exosomal miRNA in gliomas is needed for innovative diagnosis and treatment approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kekoolani S. Visan, Richard J. Lobb, Shu Wen Wen, Justin Bedo, Luize G. Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T. Simpson, Amy E. McCart Reed, Sarah J. Everitt, Michael P. MacManus, Gunter Hartel, Carlos Salomon, Sunil R. Lakhani, David Fielding, Andreas Moeller
Summary: Lung cancer is a leading cause of cancer-related death worldwide and has low survival rates due to lack of early detection. A study on a lung cancer biomarker based on a simple blood test shows promising advantages for diagnostic assessment. The study identifies a specific micro-RNA, miR-3182, as a potential biomarker for lung cancer diagnosis that can be detected in the blood.
Article
Genetics & Heredity
Tamyres Mingorance Carvalho, Guillermo Ortiz Brasil, Tayana Schultz Jucoski, Douglas Adamoski, Rubens Silveira de Lima, Cleverton C. Spautz, Karina Furlan Anselmi, Patricia Midori Murobushi Ozawa, Iglenir Joao Cavalli, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia, Enilze Maria de Souza Fonseca Ribeiro
Summary: The study identified miR-320a and miR-4433b-5p as highly specific and sensitive biomarkers for distinguishing breast cancer from controls, regardless of sample source. In tissues, lower levels of miR-150-5p and higher levels of miR-142-5p were significant biomarkers. Combining these miRNAs in panels improved the ability to differentiate breast cancer patients from controls.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Meropi Plousiou, Alessandro De Vita, Giacomo Miserocchi, Erika Bandini, Ivan Vannini, Mattia Melloni, Nestory Masalu, Francesco Fabbri, Patrizia Serra
Summary: This study reveals the important role of exosomic miR-142-3p in the tumor microenvironment of retinoblastoma and identifies new molecular targets that can control tumor growth, providing insights for the development of a forward-looking miR-based strategy.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Surgery
Narimantas E. Samalavicius, Tadas Kaminskas, Zygimantas Zidonis, Vinsas Janusonis, Olegas Deduchovas, Vitalijus Eismontas, Vaida Nausediene, Audrius Dulskas
Summary: The study compared robotic cholecystectomy (RC) with laparoscopic cholecystectomy (LC) and found no significant differences in hospital stay, blood loss, or complications, but RC had longer operative times. Therefore, robotic cholecystectomy using the Senhance robotic platform appears to be safe, while laparoscopic cholecystectomy may be helpful in gaining robotic surgery skills.
ACTA CHIRURGICA BELGICA
(2022)
Letter
Gastroenterology & Hepatology
Narimantas E. Samalavicius, Vita Klimasauskiene, Vinsas Janusonis, Robertas S. Samalavicius, Tomas Janusonis, Audrius Dulskas
COLORECTAL DISEASE
(2022)
Editorial Material
Gastroenterology & Hepatology
Narimantas E. Samalavicius, Vita Klimasauskiene, Audrius Dulskas
DISEASES OF THE COLON & RECTUM
(2022)
Article
Surgery
Audrius Dulskas, Vidas Petrauskas, Povilas Kavaliauskas, Virginijus Sapoka, Narimantas E. Samalavicius
Summary: This study reveals that 1/3 of patients undergoing TEM experience rectal wall suture dehiscence in the early postoperative period, but it does not result in significant clinical manifestations. In the late postoperative period, there is no difference in bowel function.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
N. E. Samalavicius, A. Dulskas, V Janusonis, V Klimasauskiene, V Eismontas, O. Deduchovas, T. Janusonis, R. Markelis, E. Smolskas
Summary: This study evaluated the initial experience of a single robotic center using the Senhance (R) robotic systems in colorectal surgery. The results showed that this new robotic system was safe and feasible for surgery of the colon and rectum. Further randomized controlled trials comparing different types of colorectal surgery are needed.
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Review
Surgery
Azuolas Kaminskas, Ausvydas Patasius, Marius Kincius, Virginijus Sapoka, Rytis Zilevicius, Ausra Garnelyte, Audrius Dulskas
Summary: This case report provides clinical evidence and treatment information on penile metastasis from rectal cancer, adding to the limited data available. Penile metastasis from rectal cancer often has a poor prognosis and aggressive surgical treatment is not recommended.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Audrius Dulskas, Povilas Kavaliauskas, Edgaras Kulikauskas, Edgaras Smolskas, Kornelija Pumputiene, Narimantas E. Samalavicius, Joseph W. Nunoo-Mensah
Summary: The study assessed the occurrence of common symptoms in the LARS score in a large general population and found that these symptoms are common in the general population. Previous surgeries, age, sex, comorbidities, and medication are some factors that influence the LARS score.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Narimantas Evaldas Samalavicius, Zygimantas Kuliesius, Robertas Stasys Samalavicius, Renatas Tikuisis, Edgaras Smolskas, Zilvinas Gricius, Povilas Kavaliauskas, Audrius Dulskas
Summary: This study reported the overall experience, perioperative and long-term survival results of hand assisted laparoscopic surgery (HALS) for colorectal cancer in a single tertiary referral center in Lithuania. The surgery was found to be feasible and safe, with the advantages of minimally invasive surgery, good perioperative parameters, adequate oncological quality, and excellent survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Audrius Dulskas, Justas Kuliavas, Artiomas Sirvys, Augustinas Bausys, Marius Kryzauskas, Klaudija Bickaite, Vilius Abeciunas, Tadas Kaminskas, Tomas Poskus, Kestutis Strupas
Summary: The presence of anastomotic leaks was found to be a marker of worse oncologic outcomes in patients who underwent right hemicolectomy for cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Audrius Dulskas, Philip F. Caushaj, Domas Grigoravicius, Liu Zheng, Richard Fortunato, Joseph W. Nunoo-Mensah, Narimantas E. Samalavicius
Summary: Based on a survey of surgeons, our study reveals an age-based preference for minimally invasive surgical techniques and organ-preserving techniques in the treatment of rectal cancer. Only a minority of specialists adhere to international guidelines for treating early rectal cancer.
ANNALS OF COLOPROCTOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Narimantas E. Samalavicius, Vita Klimasauskiene, Vaida Nausediene, Henrieta Janusonyte-Mongirdiene, Algirdas Liekis, Audrius Dulskas
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Audrius Dulskas
Summary: This study aims to investigate the incidence of faecal incontinence (FI) in colorectal surgical clinics worldwide, as well as the treatment choices and accessibility to diagnostic tools/advanced treatments. An international multicentre snapshot audit will be conducted over an 8-week period. The results will be published in international journals and prepared in accordance with STROBE guidelines.
COLORECTAL DISEASE
(2023)
Article
Medicine, General & Internal
Audrius Dulskas, Dovile Cerkauskaite, Ausvydas Patasius, Giedre Smailyte
Summary: This study investigated the incidence, mortality trends, and survival of gallbladder and extrahepatic bile duct cancer in Lithuania between 1998 and 2017. The results showed a decrease in incidence and mortality rates for both genders, with higher rates in females. The 1-year and 5-year relative survival rates showed a steady increase during the study period among males and females.
MEDICINA-LITHUANIA
(2023)
Letter
Surgery
Ievgen Kvasnevskyi, Rasa Bradunaite, Mikhail Kashtalyan, Aleksandr Kvasnevskyi, Narimantas E. Samalavicius, Algirdas Konradas Liekis, Daiva Luniene, Audrius Dulskas
BRITISH JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Gintare Valeikaite-Tauginiene, Agne Kraujelyte, Eligijus Poskus, Valdemaras Jotautas, Zilvinas Saladzinskas, Algimantas Tamelis, Paulius Lizdenis, Audrius Dulskas, Narimantas Evaldas Samalavicius, Kestutis Strupas, Tomas Poskus
Summary: The purpose of this study was to identify the main surgical factors affecting long-term Quality of life (QoL) among colorectal cancer patients after surgery. The results showed that QoL returns to preoperative levels six years after surgery. Age, stoma formation, adjuvant treatment, and rectal cancer were identified as independent risk factors for worse QoL after six years of surgical intervention.
MEDICINA-LITHUANIA
(2022)