Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

(2020) Brian C. Gilmour et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NAD+ Metabolism and Regulation: Lessons From Yeast

(2020) Trevor Croft et al.   Biomolecules

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

(2020) Nady Braidy et al.   EXPERIMENTAL GERONTOLOGY

Keeping the balance in NAD metabolism

(2019) Øyvind Strømland et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cross-talk in NAD+ metabolism: insights from Saccharomyces cerevisiae

(2019) Christol James Theoga Raj et al.   CURRENT GENETICS

Updates on the epigenetic roles of sirtuins

(2019) Tatsiana Kosciuk et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in obese, non-diabetic men

(2019) Ole L Dollerup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men

(2019) Ole L. Dollerup et al.   JOURNAL OF PHYSIOLOGY-LONDON

NAD metabolism: Implications in aging and longevity

(2018) Keisuke Yaku et al.   AGEING RESEARCH REVIEWS

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism

(2018) Ivan Orlandi et al.   Frontiers in Genetics

Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging

(2017) Ivan Orlandi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NAD + in Aging: Molecular Mechanisms and Translational Implications

(2017) Evandro F. Fang et al.   TRENDS IN MOLECULAR MEDICINE

During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent

(2017) Ivan Orlandi et al.   Redox Biology

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae

(2016) Marc R. Gartenberg et al.   GENETICS

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae

(2016) Marc R. Gartenberg et al.   GENETICS

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

(2015) Christian Dölle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae

(2014) Michiko Kato et al.   DNA REPAIR

YCL047C/POF1Is a Novel Nicotinamide Mononucleotide Adenylyltransferase (NMNAT) inSaccharomyces cerevisiae

(2014) Michiko Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Protein Copy Number in Yeast: The NAD+ Metabolome

(2014) Szu-Chieh Mei et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection

(2013) Yuling Chi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging

(2013) Austen R. D. Ganley et al.   FEMS YEAST RESEARCH

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors

(2012) Nadia Casatta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction

(2012) Alejandro Ocampo et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

NAD+biosynthesis and salvage - a phylogenetic perspective

(2012) Toni I. Gossmann et al.   FEBS Journal

Structural Basis for Sirtuin Activity and Inhibition

(2012) Hua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+Concentration

(2012) Julie M. McClure et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphate-responsive Signaling Pathway Is a Novel Component of NAD+Metabolism inSaccharomyces cerevisiae

(2011) Shu-Ping Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production

(2011) Peter Belenky et al.   PLoS One

Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

(2011) Derek L. Lindstrom et al.   PLoS Genetics

Dietary restriction and aging, 2009

(2010) Subhash D. Katewa et al.   AGING CELL

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

(2009) Yu-yi Lin et al.   CELL

Identification of Isn1 and Sdt1 as Glucose- and Vitamin-regulated Nicotinamide Mononucleotide and Nicotinic Acid Mononucleotide 5′-Nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside

(2009) Katrina L. Bogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension inSaccharomyces cerevisiae

(2009) Shu-Ping Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Quantitation of NAD+biosynthesis from the salvage pathway inSaccharomyces cerevisiae

(2009) Jennifer Sporty et al.   YEAST

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Pnc1p-Mediated Nicotinamide Clearance Modifies the Epigenetic Properties of rDNA Silencing in Saccharomyces cerevisiae

(2008) J. M. McClure et al.   GENETICS

Saccharomyces cerevisiae YOR071CEncodes the High Affinity Nicotinamide Riboside Transporter Nrt1

(2008) Peter A. Belenky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals

(2008) Peter Belenky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics