Review
Engineering, Biomedical
Morgan E. Lorkowski, Prabhani U. Atukorale, Ketan B. Ghaghada, Efstathios Karathanasis
Summary: Recent advancements have emphasized the importance of a holistic approach in cancer treatment, with iron oxide nanoparticles showing promise in seeking, sensing, and attacking solid tumors. These nanoparticles can be integrated with various stimulus mechanisms for the development of effective cancer therapy, co-delivering potent anticancer therapeutics and immune modulators. Future directions for clinical translation are also considered.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Rupa Bargakshatriya, Sumit Kumar Pramanik
Summary: Prodrugs are chemically modified derivatives of active drugs that are converted to the parent drugs in vivo. This approach has the potential to improve the bioavailability, targeting ability, therapeutic efficacy, safety, and marketability of existing pharmacological agents. In cancer therapy, prodrug application has gained attention for its ability to enhance release at tumor sites while reducing access to healthy cells. This review focuses on recent advancements in the development of fluorophore-drug conjugates for real-time monitoring of drug delivery, including stimuli-cleavable linkers and mechanisms of linker cleavage. The review concludes with a critical discussion of prospects and challenges for future prodrug development.
Article
Biochemical Research Methods
Shizhen Chen, Maosong Qiu, Ruifang Wang, Lei Zhang, Conggang Li, Chaohui Ye, Xin Zhou
Summary: In this study, we engineered a photoresponsive nanohybrid for the trimodal imaging and photothermal therapy of lung cancer. The nanohybrid exhibited superior imaging performance and therapeutic effect, and is expected to play an important role in early diagnosis of lung cancer.
BIOCONJUGATE CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Yang Qin, Xiaorui Geng, Yue Sun, Yitong Zhao, Wenyu Chai, Xiaobing Wang, Pan Wang
Summary: Ultrasound (US) is a mechanical wave that can penetrate biological tissues and has diverse applications in diagnosis and treatment. With the advancements in nanotechnology, US has found wider applications in precision medicine, particularly in tumor theranostics. This review focuses on the combination of US with micro and nanoparticles for tumor theranostics, discussing topics such as US-assisted drug delivery and sonodynamic antitumor strategy. The collaborative efficiency and physicochemical processes of US and nano-sensitizers are also analyzed. Furthermore, the review highlights the new applications of US and diagnostic nanoparticles in tumor monitoring and image-guided combined therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Liu
Summary: A novel combined chemo/photodynamic therapy has been developed using pH/ROS/MMP-2 triple-responsive drug nanocarriers for efficient treatment of solid tumors. The nanoparticles can effectively accumulate in tumors, release drugs in response to intracellular pH and ROS levels, and amplify ROS generation with external laser irradiation to achieve extraordinary therapeutic efficacy. The treatment showed substantial tumor shrinkage and eradication with low toxicity in major organs, indicating great potential for tumor therapy.
Article
Chemistry, Multidisciplinary
Carolina A. Ferreira, Shreya Goel, Emily B. Ehlerding, Zachary T. Rosenkrans, Dawei Jiang, Tuanwei Sun, Eduardo Aluicio-Sarduy, Jonathan W. Engle, Dalong Ni, Weibo Cai
Summary: Theranostic nanoparticles, specifically ultrasmall porous silica nanoparticles (UPSN) conjugated with isotopic pair Y-90/86, show promising in vivo pharmacokinetics with high target tissue accumulation and evasion from RES organs. These UPSN demonstrate both noninvasive imaging and internal radiotherapy capabilities, holding potential for future clinical translation as cancer theranostic agents.
Article
Engineering, Biomedical
Xuedi Zhang, Xue Zhao, Zheng Hua, Shanghua Xing, Jiaxuan Li, Siyuan Fei, Mingqian Tan
Summary: This study successfully designed and constructed astaxanthin nanoparticles with reactive oxygen species (ROS) and pH dual-response capability. In vitro and in vivo experiments demonstrated that these nanoparticles showed significant effects in antioxidation, protection of intestinal tissue integrity, and improvement of gut microbiota.
Review
Chemistry, Multidisciplinary
Elham Aram, Masome Moeni, Roya Abedizadeh, Davood Sabour, Hamid Sadeghi-Abandansari, Jabbar Gardy, Ali Hassanpour
Summary: This article introduces the application of iron oxide magnetic nanoparticles in cancer treatment and diagnosis, including magnetic hyperthermia, magnetic resonance imaging, and ultrasound. Smart magnetic nanoparticles can achieve intelligent controlled drug release and targeted drug delivery through external or internal stimuli, overcoming the obstacles faced by traditional chemotherapy strategies. The combination with other modalities enables multimodal therapy and diagnosis. However, despite the advantages of iron oxide magnetic nanoparticles over chemotherapy drugs, there are still challenges in clinical use.
Article
Polymer Science
Arianna Rinaldi, Riccardo Caraffi, Maria Vittoria Grazioli, Natalia Oddone, Luciana Giardino, Giovanni Tosi, Maria Angela Vandelli, Laura Calza, Barbara Ruozi, Jason Thomas Duskey
Summary: Reactive oxygen species (ROS)-sensitive drug delivery systems (DDS) that specifically respond to altered levels of ROS have emerged as an effective way to enhance the pharmaceutical efficacy of nanomedicines while reducing side effects. The use of ROS-responsive thioketal (TK) functional group in smart DDS has grown exponentially in recent years. TK-based biomaterials have been used as linkers, prodrugs, core components, gate controllers, and conformation changers in smart nanomedicines to overcome the limitations of conventional DDS and improve disease targeting.
Review
Chemistry, Multidisciplinary
Jie Yan, Bei Li, Piaoping Yang, Jun Lin, Yunlu Dai
Summary: Lanthanide nanoparticles have excellent photoresponsive performance for deep-seated tumors, making them efficient for cancer treatment and imaging, but there are still challenges in translating them to clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Meghanath B. Shete, Tulshidas S. Patil, Ashwini S. Deshpande, Gaurav Saraogi, Nupur Vasdev, Mrudul Deshpande, Kuldeep Rajpoot, Rakesh Kumar Tekade
Summary: Nanomedicine plays a crucial role in targeting therapeutics to specific sites, with various types of nanomedicines being widely recognized and utilized for disease treatment and diagnosis. However, the advancement of nanotheranostics still requires collaborative efforts from a range of professionals to bring them into the market successfully.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Shuren Wang, Yanglong Hou
Summary: Magnetic nanomaterials play a crucial role in the biomedical field and have various applications such as biosensors, drug delivery vehicles, and diagnostic agents. Researchers are continuously developing new types of magnetic nanomaterials, like iron carbide nanoparticles, to improve performance. Magnetic nanoparticles responsive to exogenous or endogenous stimuli have been developed, enhancing their applicability in more complex scenarios. These nanoparticles can respond to stimuli such as acidity, hydrogen peroxide, light, and magnetic fields.
Article
Materials Science, Multidisciplinary
Fatemeh Oroojalian, Shahla Karimzadeh, Siamak Javanbakht, Maryam Hejazi, Behzad Baradaran, Thomas J. Webster, Ahad Mokhtarzadeh, Rajender S. Varma, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Stimuli-responsive systems based on metal-organic frameworks (MOFs) are smart nanoplatforms with high surface area and biocompatibility, which have attracted significant attention in the biomedical field. These MOFs are designed to change their properties in response to specific stimuli, making them versatile platforms for biomedical applications such as imaging and therapy.
Article
Materials Science, Multidisciplinary
Yu Qi, Xu Yan, Tian Xia, Sijin Liu
Summary: Nano-based cancer theranostics face challenges in achieving expected efficacy due to low nanoparticle accumulation in tumors. Cell-aided strategies, particularly involving macrophages, show promise in improving the therapeutic efficacy of nanomedicines. Further research is needed to understand the interactions between macrophages, nanomedicines, and tumor cells for enhancing anti-cancer immunity in the tumor microenvironment.
MATERIALS & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Qing Meng, Zhou Xue, Shunli Chen, Min Wu, Peng Lu
Summary: Responsive antimicrobial materials were prepared by designing pH-responsive cellulose-based nanoparticles grafted with PEI and emulsifying OEO. The nanoparticles showed pH-responsive properties and achieved excellent antimicrobial effects. The developed Pickering emulsion demonstrated controlled release of antimicrobial agents in response to pH stimulation and exhibited smart antimicrobial capabilities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Sergey Brezgin, Anastasiya Kostyusheva, Natalia Ponomareva, Ekaterina Bayurova, Alla Kondrashova, Anastasia Frolova, Olga Slatinskaya, Landysh Fatkhutdinova, Georgy Maksimov, Mikhail Zyuzin, Ilya Gordeychuk, Alexander Lukashev, Sergey Makarov, Alexander Ivanov, Andrey A. Zamyatnin Jr, Vladimir Chulanov, Alessandro Parodi, Dmitry Kostyushev
Summary: Biological nanoparticles, such as extracellular vesicles (EVs) and extracellular vesicle-mimetic nanovesicles (EMNVs), have been extensively studied as drug delivery vehicles in medical applications. This study investigated the properties and drug delivery abilities of EVs and EMNVs, and analyzed their use for delivering the chemotherapeutic drug doxorubicin. EMNVs were found to be more effectively internalized, while EVs showed higher intracellular release of doxorubicin.
Review
Biotechnology & Applied Microbiology
Sergey Brezgin, Alessandro Parodi, Anastasiya Kostyusheva, Natalia Ponomareva, Alexander Lukashev, Darina Sokolova, Vadim S. Pokrovsky, Olga Slatinskaya, Georgy Maksimov, Andrey A. Zamyatnin Jr, Vladimir Chulanov, Dmitry Kostyushev
Summary: Extracellular vesicles (EVs), cell-derived biological nanoparticles, have gained significant interest for drug delivery due to their ideal biocompatibility, safety, ability to cross biological barriers, and surface modification potential. However, the translation of EVs into practical applications has been challenging due to issues in up-scaling, synthesis, and quality control methods. Advances in manufacturing technology now allow EVs to carry various therapeutic cargoes, and new technologies have been introduced to improve EV production, isolation, characterization, and standardization.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Oncology
Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. A. Zamyatnin Jr, Alexandr V. V. Bazhin, Mazdak Ganjalikhani-Hakemi
Summary: Through this study, we found that PD-L1 stimulation can promote the proliferation and survival of AML stem cells, possibly through regulating the metabolic pathways of leukemic cells. PD-L1 stimulation affects glucose and fatty acid metabolism, increasing the expression of the pentose phosphate pathway and glycolysis in HL-60 and THP-1 cells, as well as increasing the expression of CPT1A while decreasing ACC1 expression.
Editorial Material
Oncology
Lyudmila V. Savvateeva, Evgeni Yu. Zernii, Andrey A. Zamyatnin
CURRENT CANCER DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Larisa N. Ikryannikova, Neonila V. Gorokhovets, Darya A. Belykh, Leonid K. Kurbatov, Andrey A. Zamyatnin Jr
Summary: This article introduces the research on the relationship between bacteria and human tumors, including the efforts and achievements of ancient and modern scientists, as well as the challenges and achievements of 21st century science in using bacteria for cancer treatment. It also discusses the future possibilities of bacterial cancer therapy, including the creation of bacterial microrobots or bacteriobots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina P. Kolesova, Vera S. Egorova, Anastasiia O. Syrocheva, Anastasiia S. Frolova, Dmitry Kostyushev, Anastasiia Kostyusheva, Sergey Brezgin, Daria B. Trushina, Landysh Fatkhutdinova, Mikhail Zyuzin, Polina A. Demina, Evgeny V. Khaydukov, Andrey A. Zamyatnin, Alessandro Parodi
Summary: Proteolytic activity plays a crucial role in cell homeostasis and function, with implications in cancer progression and treatment response. Endosomes, which are often the final destination of internalized nanoparticles, are major sites of cellular proteolytic activity. However, little is known about the impact of nanoparticles on endosomal biology. In this study, we generated albumin nanoparticles with varying resistance to proteolysis and demonstrated a relationship between their sensitivity to proteases and drug delivery properties, irrespective of the degree of proteolytic degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Natalia Ponomareva, Ekaterina Bayurova, Natalia Zakirova, Alla Kondrashova, Irina Goptar, Anastasiya Nikiforova, Anna Sudina, Yurii Babin, Ilya Gordeychuk, Alexander Lukashev, Andrey A. Zamyatnin Jr, Alexander Ivanov, Vladimir Chulanov
Summary: APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses. Researchers developed a CRISPR-activation-based approach to induce APOBEC/AID overexpression and control its effects on HBV replication and cellular toxicity. The study highlights the potential for precise control of APOBEC/AID activation as a strategy for suppressing HBV replication without toxicity.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Biochemistry & Molecular Biology
Konstantin I. Ivanov, Olga V. Samuilova, Andrey A. Zamyatnin Jr
Summary: Recent advancements in RNA sequencing technology have allowed for the exploration of the complex and versatile world of long noncoding RNAs (lncRNAs) in the human genome. Once thought to be transcriptional noise, lncRNAs are now recognized as essential regulators of gene expression networks that control development, homeostasis, and disease progression. The regulatory functions of lncRNAs are diverse, acting at various levels within the cell, and there is growing evidence for their involvement in lymphatic vascular development and disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Peter A. Ivanov, Tatiana V. Gasanova, Maria N. Repina, Andrey A. Zamyatnin Jr
Summary: Virus-specific proteins can trigger hypersensitive response (HR) in plants, which is a type of cell death. The main cell death signaling pathway involves the interaction between HR-inducing proteins and nucleotide-binding leucine-rich repeats (NLR) proteins encoded by plant resistance genes. NLR proteins can act as both sensors and helpers, or form an activation network leading to oligomerization and formation of membrane-associated resistosomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Jiazheng Sun, Andrey A. Zamyatnin, Xiangliang Yuan, Yi Xiao, Hongzhong Li
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vera S. Egorova, Ekaterina P. Kolesova, Manu Lopus, Neng Yan, Alessandro Parodi, Andrey A. Zamyatnin
Summary: Cathepsin B is a lysosomal cysteine protease involved in various cellular processes and its overexpression and activity have been linked to pathological conditions such as cancer. Targeting cathepsin B activity has become a promising strategy for tumor-specific therapy and drug delivery. This review summarizes different technologies designed to improve cancer treatments by responsive to cathepsin B activity, which plays a key role in disease progression and treatment response.
Article
Biochemistry & Molecular Biology
Svetlana Yu. Maklakova, Anton V. Lopukhov, Alexandr D. Khudyakov, Sergey V. Kovalev, Maria P. Mazhuga, Olga E. Chepikova, Andrey A. Zamyatnin Jr, Alexander G. Majouga, Natalia L. Klyachko, Elena K. Beloglazkina
Summary: This study reports the synthesis and evaluation of atorvastatin conjugates targeting the galactose-specific hepatic asialoglycoprotein receptor (ASGPR). The prepared conjugates showed increased water solubility and demonstrated potent binding to the ASGPR. The conjugates with an amide bond displayed optimal stability and effectively inhibited HMG-R activity. These findings suggest that these compounds have the potential to be developed as orally administered prodrugs of atorvastatin.
RSC MEDICINAL CHEMISTRY
(2023)
