Linker and N-Terminal Domain Engineering of Pyrrolysyl-tRNA Synthetase for Substrate Range Shifting and Activity Enhancement

Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs

(2018) Julian C. W. Willis et al.   Nature Chemistry

Upgrading aminoacyl-tRNA synthetases for genetic code expansion

(2018) Oscar Vargas-Rodriguez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase

(2017) Tateki Suzuki et al.   Nature Chemical Biology

Expanding the genetic code of Mus musculus

(2017) Songmi Han et al.   Nature Communications

Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics

(2016) Vangmayee Sharma et al.   ACS Chemical Biology

Reassignment of a rare sense codon to a non-canonical amino acid inEscherichia coli

(2015) Takahito Mukai et al.   NUCLEIC ACIDS RESEARCH

Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase

(2014) Han Xiao et al.   ACS Chemical Biology

Polyspecific pyrrolysyl-tRNA synthetases from directed evolution

(2014) Li-Tao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligation of Expressed Protein α-Hydrazides via Genetic Incorporation of an α-Hydroxy Acid

(2012) Yi-Ming Li et al.   ACS Chemical Biology

A Facile Method to Synthesize Histones with Posttranslational Modification Mimics

(2012) Zhiyong U. Wang et al.   BIOCHEMISTRY

Near-cognate suppression of amber, opal and quadruplet codons competes with aminoacyl-tRNAPylfor genetic code expansion

(2012) Patrick O'Donoghue et al.   FEBS LETTERS

PylSn and the Homologous N-terminal Domain of Pyrrolysyl-tRNA Synthetase Bind the tRNA That Is Essential for the Genetic Encoding of Pyrrolysine

(2012) Ruisheng Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant with a Broad Substrate Spectrum

(2012) Yane-Shih Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genetically encoded photocaged Nε-methyl-l-lysine

(2010) Yane-Shih Wang et al.   Molecular BioSystems

Identification of Amino Acids in the N-terminal Domain of Atypical Methanogenic-type Seryl-tRNA Synthetase Critical for tRNA Recognition

(2009) Jelena Jaric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality

(2009) Kayo Nozawa et al.   NATURE

Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases

(2008) Takahito Mukai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode Nɛ-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification

(2008) Tatsuo Yanagisawa et al.   CHEMISTRY & BIOLOGY

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology