Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

(2018) Mara Vinci et al.   NATURE MEDICINE

Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels

(2017) David Gomez-Zepeda et al.   JOURNAL OF NEUROCHEMISTRY

New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis

(2017) Alexandre Plessier et al.   Oncotarget

Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

(2017) Tammy Hennika et al.   PLoS One

Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood–Brain Barrier

(2016) Catarina Chaves et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model

(2016) R. K. Mittapalli et al.   MOLECULAR CANCER THERAPEUTICS

A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells

(2016) Katherine L. Misuraca et al.   NEOPLASIA

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

(2015) David Castel et al.   ACTA NEUROPATHOLOGICA

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib

(2015) Mark C. de Gooijer et al.   INVESTIGATIONAL NEW DRUGS

Tumor location, but not H3.3K27M, significantly influences the blood–brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma

(2015) Ergys Subashi et al.   JOURNAL OF NEURO-ONCOLOGY

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

(2015) Catherine S Grasso et al.   NATURE MEDICINE

Efflux transporters in blood-brain interfaces of the developing brain

(2015) Nathalie Strazielle et al.   Frontiers in Neuroscience

DIPG in Children – What Can We Learn from the Past?

(2015) Magimairajan Issai Vanan et al.   Frontiers in Oncology

Optimized Approaches for Quantification of Drug Transporters in Tissues and Cells by MRM Proteomics

(2014) Bhagwat Prasad et al.   AAPS Journal

aLFQ: an R-package for estimating absolute protein quantities from label-free LC-MS/MS proteomics data

(2014) George Rosenberger et al.   BIOINFORMATICS

Irinotecan and temozolomide brain distribution: a focus on ABCB1

(2014) Lauriane Goldwirt et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Convection enhanced delivery of carmustine to the murine brainstem: A feasibility study

(2014) A. Charlotte P. Sewing et al.   JOURNAL OF NEUROSCIENCE METHODS

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

(2014) Kathryn R Taylor et al.   NATURE GENETICS

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues

(2013) F. Lin et al.   CLINICAL CANCER RESEARCH

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

(2013) Yutaro Hoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Treatment of Children with Diffuse Intrinsic Pontine Gliomas with Chemoradiotherapy Followed by a Combination of Temozolomide, Irinotecan, and Bevacizumab

(2013) Wafik Zaky et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma

(2013) Susanna J. E. Veringa et al.   PLoS One

Breast Cancer Resistance Protein and P-Glycoprotein in Brain Cancer: Two Gatekeepers Team Up

(2012) Sagar Agarwal et al.   CURRENT PHARMACEUTICAL DESIGN

An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing

(2012) Yasuyuki Aoki et al.   JOURNAL OF NEURO-ONCOLOGY

Diffuse intrinsic pontine glioma—current status and future strategies

(2011) Soumen Khatua et al.   CHILDS NERVOUS SYSTEM

Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience

(2011) Johannes E. Wolff et al.   JOURNAL OF NEURO-ONCOLOGY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid

(2009) J. Shen et al.   CANCER RESEARCH

Tyrosine Kinase Inhibitor Enhances the Bioavailability of Oral Irinotecan in Pediatric Patients With Refractory Solid Tumors

(2009) Wayne L. Furman et al.   JOURNAL OF CLINICAL ONCOLOGY

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N- -6-[5-( methyl)-2-furyl]-4-quinazolinamine; GW572016)

(2008) J. W. Polli et al.   DRUG METABOLISM AND DISPOSITION

Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats

(2008) Tripta Bansal et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In Situ Mouse Carotid Perfusion Model: Glucose and Cholesterol Transport in the Eye and Brain

(2008) Julie Cattelotte et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A Children's Oncology Group phase I study

(2008) Kristin A. Bradley et al.   NEURO-ONCOLOGY

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

(2008) Junichi Kamiie et al.   PHARMACEUTICAL RESEARCH