Review
Materials Science, Multidisciplinary
Zhaojun Jia, Xiaoxue Xu, Donghui Zhu, Yufeng Zheng
Summary: Trauma-and disease-related skeletal defects and illnesses are causing problems for millions of people, particularly in an aging world. The convergence of additive manufacturing (AM) and bone tissue engineering (BTE) has opened up the era of personalized bone healthcare, by using design, printing, and engineering to create custom 3D architected scaffolds. This review provides an overview of theories, advances, and trends in this field, covering biomaterials, computational tools, and engineering processes. The goal is to produce customized and biomimetic (bio)scaffolds for next-generation bone healthcare.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Cyrus W. Beh, Dionis S. Yew, Ruth J. Chai, Sau Yin Chin, Yiqi Seow, Shawn S. Hoon
Summary: The study introduces a hydrogel 3D printer that can print complex structures quickly and continuously, and is capable of multi-material printing. This innovative approach helps address the nutrient supply issue in bioprinting.
Article
Materials Science, Multidisciplinary
Boris Chichkov
Summary: This paper presents a personal view on the potential development and applications of laser printing technologies based on laser-induced forward transfer of inorganic and biological materials, including micro- and nanoparticles, living cells, and microorganisms.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Chemistry, Multidisciplinary
Jacob Dairaghi, Dan Rogozea, Rachel Cadle, Joseph Bustamante, Leni Moldovan, Horia Petrache, Nicanor Moldovan
Summary: The use of 3D printing technology enables the production of anatomically correct and personalized middle ear protheses, which opens the way for the in vitro generation of personalized middle ear prostheses for implantation.
APPLIED SCIENCES-BASEL
(2022)
Review
Polymer Science
Quinten Thijssen, Joseph Toombs, Chi Chung Li, Hayden Taylor, Sandra Van Vlieberghe
Summary: This review comprehensively discusses the potential of volumetric 3D-printing, summarizing the theoretical framework of photopolymerization and highlighting the advancements in light-based 3D-printing techniques. Special attention is given to the subfield of volumetric bioprinting. The review provides important discussions and prospects for those interested in the field of volumetric 3D-printing.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Chloe Parulski, Laure-Anne Bya, Justine Goebel, Anne-Catherine Servais, Anna Lechanteur, Brigitte Evrard
Summary: This study aimed to develop low-dose solid oral forms containing hydrocortisone for pediatric patients using hot-melt extrusion coupled with fused deposition modeling. Red mini-waffle shapes with drug loads of 2, 5 and 8 mg were successfully printed. Despite the small dimensions, mass and content uniformity, hardness and friability tests complied with European Pharmacopeia specifications. This study demonstrates the use of FDM for producing innovative pediatric-friendly printed shapes of advanced pharmaceutical quality to practice personalized medicine.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Jigar Vyas, Isha Shah, Sudarshan Singh, Bhupendra G. Prajapati
Summary: 3D/4D printing technology is gaining popularity in otolaryngology for manufacturing anatomical models, personalized implants, etc. Smart polymeric materials are commonly used in tissue engineering applications. Bioprinting has the potential to improve the safety and efficacy of otolaryngology treatments and transform the field of tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Aurelio Salerno, Paolo A. Netti
Summary: The review discusses the recent scientific literature on AM fabrication of drug delivery scaffolds for TE, focusing on bioactive molecule loading into 3D porous scaffolds and their release effects on cell fate and tissue growth. strategies such as bioprinting were reviewed to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. The integration of AM, microfluidic, and soft lithography is highlighted for enhancing 3D porous scaffold bioactivation towards functional bioengineered tissues and organs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Analytical
Tarek Kassem, Tanoy Sarkar, Trieu Nguyen, Dipongkor Saha, Fakhrul Ahsan
Summary: 3D printing technology can be used for personalized dosing pharmaceuticals as well as creating 3D models for drug screening, sensing, testing, and organ-on-chip applications. Efforts are being made to improve the limitations of this technology, such as restricted excipient choices, time constraints, industrial production limitations, and overall costs. This review provides an overview of the 3D printing process, types of materials used, and the pros and cons of different techniques in creating solid dosage forms and producing 3D models for sensing, testing, and screening substances.
Article
Chemistry, Multidisciplinary
Karen Dubbin, Ziye Dong, Dan M. Park, Javier Alvarado, Jimmy Su, Elisa Wasson, Claire Robertson, Julie Jackson, Arpita Bose, Monica L. Moya, Yongqin Jiao, William F. Hynes
Summary: In this study, a technique for patterning microbes in 3D geometries using projection stereolithography was developed and successfully used to demonstrate the impact of biofilm structure on microbial activity. The ability to print bacteria and fabricate a biofilm with different fluorescence E. coli strains was verified, showing potential for future work on engineered biofilms and complex 3D structures in microbial cultures.
Review
Polymer Science
HongXin Cai, Xiaotong Xu, Xinyue Lu, Menghua Zhao, Qi Jia, Heng-Bo Jiang, Jae-Sung Kwon
Summary: With the maturity of CAD/CAM technologies, 3D printing materials for dentistry have attracted research interest for their efficiency and low cost in clinical treatment. This review aims to classify, summarize, and discuss dental materials for 3D printing and 4D printing from a clinical perspective.
Article
Materials Science, Ceramics
Christoph J. Roser, Ralf Erber, Peter Rammelsberg, Christopher J. Lux, Aysegul Kurt, Stefan Rues, Franz Sebastian Schwindling, Christopher Herpel
Summary: This study compared the behavior of osteoblasts on additive manufactured and milled zirconia materials, and found that the surface roughness of the two groups differed significantly, but there was no significant effect on cell adhesion, proliferation, and coverage. The investigated 3D printing workflow did not have a detrimental effect on osteoblast behavior.
CERAMICS INTERNATIONAL
(2023)
Review
Materials Science, Multidisciplinary
Amir A. Elhadad, Ana Rosa-Sainz, Raquel Canete, Estela Peralta, Belen Begines, Mario Balbuena, Ana Alcudia, Y. Torres
Summary: This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It provides an overview of various 3D printing techniques and their applications, with a focus on materials such as composites, hybrids, and smart materials. The article also discusses the latest developments in 4D bioprinting technology and outlines present challenges and future regulations.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Biochemical Research Methods
Shukufe Amukarimi, Zahra Rezvani, Neda Eghtesadi, Masoud Mozafari
Summary: The development of smart biomaterials has led to enhanced medical facilities in this century. One shining example is the rise of four-dimensional bioprinting technology, which can fabricate stimuli-responsive cell-laden structures that can undergo morphological changes in a pre-planned way.
Review
Biochemistry & Molecular Biology
Damien Brezulier, Louis Chaigneau, Sylvie Jeanne, Ronan Lebullenger
Summary: Cleft lip and palate is a common congenital malformation, with surgical repair being crucial for functional and aesthetic outcomes. Research on substitute biomaterials, such as bioactive glasses, is gaining attention due to complications associated with traditional autogenous bone grafts. Advances in materials and technologies, like 3D printing of scaffolds combining bioglass with a biocompatible matrix, offer new possibilities for reconstructive surgery in cleft palates.
Article
Instruments & Instrumentation
Katie Glover, Essyrose Mathew, Giulia Pitzanti, Erin Magee, Dimitrios A. Lamprou
Summary: The treatment strategy for diabetic foot ulcer (DFU) is complex, requires multiple therapeutic approaches, and often results in amputation. Bioprinting technologies show innovative potential in fabricating antibiotic scaffolds for DFU treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Sara Basile, Essyrose Mathew, Ida Genta, Bice Conti, Rossella Dorati, Dimitrios A. Lamprou
Summary: This study validated an optimized FDM 3D printing method for the manufacturing of personalized medical implants, particularly fistulas. Different types of filaments were produced using hot melt extrusion, and the printed fistulas were characterized using various physicochemical analysis methods. The results demonstrated that TPU material is suitable for 3D printing and successful drug loading. Drug release testing showed sustained release, meeting the requirements for implants in the patient's body.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Toxicology
Antonella Rosa, Mariella Nieddu, Giulia Pitzanti, Rosa Pireddu, Francesco Lai, Maria Cristina Cardia
Summary: This study investigated the impact of different types of solid lipid nanoparticles (SLN), both empty and loaded with curcumin and resveratrol, on cell viability and lipid metabolism in 3T3 fibroblasts. The results showed that empty SLN did not exhibit cytotoxicity, while curcumin-loaded and resveratrol-loaded SLN reduced cell viability. Additionally, the lipid content and encapsulated drug in the SLN affected cell lipid metabolism.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Camila J. Picco, Emilia Utomo, Andrea McClean, Juan Dominguez-Robles, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Peter E. McKenna, Jonathan G. Acheson, Dessislava Malinova, Ryan F. Donnelly, Eneko Larraneta
Summary: Implantable drug-eluting devices have the potential to improve treatment of chronic conditions by providing sustained therapeutic effects and reducing pill burden for patients. The use of modern technologies like 3D printing allows for the production of customizable devices. In this study, subcutaneous implants loaded with olanzapine were formulated using the robocasting technique and demonstrated sustained drug release over a period of 200 days.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Correction
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Natalia Moreno-Castellanos, Sarah A. Stewart, Camila J. Picco, Qonita Kurnia Anjani, Jon Ander Simon, Ivan Penuelas, Ryan F. Donnelly, Eneko Larraneta
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Nicole Ioannou, Jinyuan Luo, Mengqi Qin, Matteo Di Luca, Essyrose Mathew, Aristides D. Tagalakis, Dimitrios A. Lamprou, Cynthia Yu-Wai-Man
Summary: A sustained release 5-FU implant composed of PCL and CS was fabricated using 3D printing technology for preventing conjunctival fibrosis after glaucoma surgery. The implant released 5-FU steadily over 8 weeks and effectively suppressed fibroblast contractility. It exhibited biocompatibility, smooth surface, and degradability.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Edward Weaver, Essyrose Mathew, Jay Caldwell, Andrew Hooker, Shahid Uddin, Dimitrios A. Lamprou
Summary: In this study, a UV LCD printer was used to produce microfluidic chips for liposomal synthesis, and the limitations of UV LCD printing in terms of resolution and print speed optimization were tested. By varying channel parameters, the essential properties for optimal liposomal formulation were investigated, and liposomes with sizes of approximately 120 nm and polydispersity index values of <= 0.12 were successfully synthesized. The influence of total flow rates and lipid choice on microfluidic setup optimization was also investigated in depth.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Masoud Adhami, Niamh K. Martin, Ciara Maguire, Aaron J. Courtenay, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are the leading cause of death globally. Drug eluting implants, that provide accurate drug release and minimize adverse side effects, have the potential for significant advancements in the treatment of these diseases.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Beata-Maria Benko, Dimitrios. A. A. Lamprou, Anna Sebestyen, Romana Zelko, Istvan Sebe
Summary: Glioblastoma is a challenging CNS tumor, and the anti-alcoholism drug disulfiram (DS) has potential anticancer activity that could be used against GB. However, there are limitations in delivering DS to the brain-tumor tissue for effective treatment.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Multidisciplinary
Li Zhao, Lalitkumar K. Vora, Stephen A. Kelly, Linlin Li, Eneko Larraneta, Helen O. McCarthy, Ryan F. Donnelly
Summary: Antibiotic resistance is a serious health problem and is expected to worsen in the future. Researchers have developed a hydrogel-forming microarray patch system that can deliver antibiotics in a sustained manner.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Qonita Kurnia Anjani, Camila J. Picco, Anna Korelidou, Erin Magee, Ryan F. Donnelly, Eneko Larraneta
Summary: Bacterial vaginosis (BV) is an abnormal condition caused by changes in the vaginal microbiota. Current treatment involves the use of antibiotics, but frequent application is needed. This research proposes a prolonged release of metronidazole (MTZ) using biodegradable and biocompatible polymers in the form of intravaginal devices, which can reduce the frequency of administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Instruments & Instrumentation
Masoud Adhami, Camila J. Picco, Usanee Detamornrat, Qonita K. Anjani, Victoria A. Cornelius, Pamela Robles-Martinez, Andriana Margariti, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are a leading cause of death worldwide and significantly impact quality of life. 3D-printed biodegradable vascular grafts loaded with a drug called clopidogrel were developed using digital light processing technology. These grafts provide sustained drug release, reduce platelet deposition, and create a supportive environment for cellular attachment, viability, and growth.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
