Article
Materials Science, Biomaterials
Haruka Hirayama, Saliu Alao Amolegbe, Md Saidul Islam, Mohammad Atiqur Rahman, Nonoka Goto, Yoshihiro Sekine, Shinya Hayami
Summary: In this study, encapsulation and release of antimalarial drug quinine using three nanocarriers were investigated, with pH and thermal optimization effects on drug adsorption and release from the nanocarriers explored.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Hui Xie, Zhiguo He, Yanxing Liu, Changbo Zhao, Bing Guo, Caizhen Zhu, Jian Xu
Summary: This study demonstrates that mesoporous silica aerogels can serve as carriers for delivering slightly soluble antibacterial agents, forming uniform nanocrystals and enhancing antibacterial efficiency. The loaded aerogels exhibit high inhibition rates and good biocompatibility.
Article
Chemistry, Multidisciplinary
Hanine Zakaria, Riham El Kurdi, Digambara Patra
Summary: The main purpose of this paper is to design curcumin loaded PLGA nanocapsules for the selective detection of dopamine using fluorescence spectroscopy. The nanocapsules were synthesized using a solid-in-oil-in-water (s/o/w) emulsion technique and were coated with a poly(diallyldimethylammonium)chloride (PDDA) polymer. The nanocapsules showed high selectivity and specificity towards dopamine, and the fluorescence emission technique was found to be selective, easy, fast, and low cost for the determination of dopamine.
Article
Chemistry, Multidisciplinary
Tianyu Li, Efrain E. Rodriguez
Summary: This study demonstrated the hydrothermal conversion of mesoporous TiO2 to mesoporous SrTiO3, with controlled pore size distribution and potential for high-temperature applications due to thermal stability.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Khushali Parekh, Kartik Hariharan, Zhi Qu, Prarthana Rewatkar, Yuxue Cao, Md. Moniruzzaman, Preeti Pandey, Amirali Popat, Tejal Mehta
Summary: This study successfully improved the water solubility of Tacrolimus using surface-functionalized mesoporous silica nanoparticles (TMSNs), and achieved better drug release and topical delivery effects by incorporating TMSNs into carbopol gel, showing potential as a novel formulation strategy for topical drug delivery of poorly soluble drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Pakamon Chitprasert, Thatchawan Dumrongchai, Akkaratch Rodklongtan
Summary: In this study, vitexin was encapsulated in CaCO3 nanoparticles using co-precipitation method to improve its bioaccessibility. The optimal conditions for encapsulation were found to be a temperature of 40 degrees C and a homogenization speed of 25,000 rpm, resulting in an encapsulation efficiency of 90.45% and a loading capacity of 28.64%. The nanoencapsulated vitexin showed enhanced solubilization, leading to increased DPPH and ABTS scavenging activities as well as improved bioaccessibility compared to free vitexin.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Chun Xu, Chang Lei, Yue Wang, Chengzhong Yu
Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biology
Julia Gornicka, Martyna Mika, Oliwia Wroblewska, Pawel Siudem, Katarzyna Paradowska
Summary: Turmeric is a strong-taste spice commonly used in Indian cuisine. It has been used for culinary and medicinal purposes for thousands of years. The main component of turmeric is curcumin, which has been extensively studied due to its various biological activities such as anticancer, antibacterial, anti-inflammatory, and antiaging effects. However, the poor bioavailability and water solubility of curcumin hinder its clinical application.
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biophysics
Ali Mahmoudi, Prashant Kesharwani, Muhammed Majeed, Yong Teng, Amirhossein Sahebkar
Summary: Curcumin is a natural compound with promising therapeutic benefits, but it suffers from low solubility and bioavailability. Incorporating curcumin into gold nanoparticles can improve its properties and enhance its anticancer and antioxidant capacities. Additionally, the combination of nanogold and curcumin can be utilized in various therapeutic methods.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Chih-Yu Lin, Chia-Min Yang, Mika Linden
Summary: Mesoporous silica nanoparticles (MSN) are potential drug carriers with high drug loading capacity and degradability under biologically relevant conditions. Dissolution studies of MCM-48 MSN in the presence of proteins show that protein concentration affects the kinetics of dissolution and leads to the formation of core-shell structured particles. The results suggest that MSN dissolution kinetics is faster under typical in vitro conditions compared to full serum conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Akanksha Dohare, Swathi Sudhakar, Bjoern Brodbeck, Ashutosh Mukherjee, Marc Brecht, Andreas Kandelbauer, Erik Schaeffer, Hermann A. Mayer
Summary: The study demonstrates that anisotropic and amphiphilic dumbbell core-shell silica microparticles with chemically selective environments can effectively entrap and release two drugs simultaneously with high efficiency. The drugs accumulate in different compartments of the particles, leading to different cancer cell inhibitory activities.
Article
Pharmacology & Pharmacy
Irene Moroni, Alfonso E. Garcia-Bennett
Summary: In this study, melatonin was encapsulated in mesoporous silica with the addition of a coating of cellulose acetate phthalate. The release kinetics of melatonin and its metabolism were investigated in simulated gastrointestinal fluids and in an in vitro model of the intestinal tract. The presence of the coating affected the release and absorption of melatonin, as well as its catabolism. The confinement of melatonin in the mesopores had a slight impact on its permeability and metabolism.
Article
Chemistry, Applied
Vignesh Krishnan, Joy Sebastian Prakash, Venkatesan Manigandan, G. Devanand Venkatasubbu, Arivalagan Pugazhendhi, Kathirvel Brindhadevi, T. Kalaivani
Summary: This study synthesized mesoporous silicon dioxide nanoparticles with different pore volumes and evaluated their toxicity effects on zebrafish. The results showed that the nanoparticles had excellent drug loading capacity and the survival rate of zebrafish was above 85%.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Razieh Heidari, Vahideh Assadollahi, Pegah Khosravian, Seyed Abbas Mirzaei, Fatemeh Elahian
Summary: The use of nucleic acid to control gene expression is crucial in cancer research, and delivering nucleic acids using nanoparticles has emerged as a safe and efficient system for gene transfer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Ghulam Muhiuddin, Ismat Bibi, Zarish Nazeer, Farzana Majid, Shagufta Kamal, Abida Kausar, Qasim Raza, Norah Alwadai, Safa Ezzine, Munawar Iqbal
Summary: The pristine and Ni-doped BaNixFe12-xO19 nanoparticles were fabricated via a microemulsion approach, and the impact of dopants on the dielectric, optical, structural, and photocatalytic properties was investigated. The doped nanoparticles exhibited enhanced remanence, saturation polarization, and photocatalytic degradation activity. The optical band gap was reduced due to the doping, and the dielectric properties were also improved. The highly doped catalyst demonstrated efficient electron-hole pair separation and achieved a higher degradation rate of crystal violet dye under visible light irradiation.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Alia Raees, Haq Nawaz Bhatti, Sameer Alshehri, Farheen Aslam, Foziah F. F. Al-Fawzan, Siham A. A. Alissa, Munawar Iqbal, Arif Nazir
Summary: This study focused on the removal of Drimaren Turquoise CL-B reactive dye using the white rot fungus Schizophyllum commune, considering current environmental conditions. Various parameters such as pH, carbon and nitrogen sources, temperature, dye concentration, and C/N ratio were investigated. The highest dye removal (95.45%) was achieved at pH 4.5, temperature 35°C, inoculum size 3 mL, veratryl alcohol mediator, glucose carbon source, and ammonium nitrate nitrogen source. The enzyme activity assay showed low laccase and lignin peroxidase (LiP) activity, while manganese peroxidase (MnP) activity was the highest. Maximum biosorption occurred at pH 1 and 313 K. The pseudo-2(nd)-order kinetic model and Freundlich isotherm were the best fit for dye removal. Overall, white rot fungus shows promise as an excellent biomaterial for removing synthetic dyes from wastewater.
ADSORPTION SCIENCE & TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hira Mahmood, Muhammad Asif, Syed Haroon Khalid, Ikram Ullah Khan, Zunera Chauhdary, Fizza Abdul Razzaq, Sajid Asghar
Summary: In this study, a composite functional wound dressing based on kappa-carrageenan and tannic acid was prepared and co-encapsulated with simvastatin and Geranium oil. The prepared films had excellent mechanical strength, high swelling rate, and good water solubility. The dressing showed superior antioxidant, anti-inflammatory, and broader anti-bacterial activity. The CS/G/TA hydrogel film exhibited excellent wound healing effect through improved angiogenesis and down regulation in the expression of inflammatory markers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Muhammad Asim, Marriam Nazir, Zunera Chauhdary, Muhammad Irfan, Syed Haroon Khalid, Sajid Asghar, Raed I. Usra, Raed Felimban, Mohammed A. S. Majrashi, Mohannad S. Hazzazi, Mohammed Alissa, Safa H. Qahl, Ghulam Hussain, Azhar Rasul, Shahzad Ali Shahid Chatha, Ikram Ullah Khan
Summary: The current study aimed to enhance the solubility and dissolution profile of dexibuprofen (Dex) by formulating ternary solid dispersions (TSDs) through solvent evaporation. The TSD formulations showed improved solubility and dissolution, as well as gastric protection and anti-inflammatory activity.
Article
Pharmacology & Pharmacy
Saima Mahmood, Nauman Rahim Khan, Ghulam Razaque, Shefaat Ullah Shah, Memuna Ghafoor Shahid, Hassan A. A. Albarqi, Abdulsalam A. A. Alqahtani, Ali Alasiri, Hafiz Muhammad Basit
Summary: This study aimed to develop and optimize a microwave-treated, physically cross-linked polymer blend film for wound healing in diabetic animals. The optimized film formulation showed enhanced physicochemical properties and improved the wound healing process in a diabetic animal model. The results suggest that microwave-treated polymer blend films have the potential to enhance wound healing and promote skin tissue regeneration in diabetic individuals.
Article
Infectious Diseases
Zikria Saleem, Abdul Haseeb, Brian Godman, Narjis Batool, Ummara Altaf, Umar Ahsan, Faiz Ullah Khan, Zia Ul Mustafa, Muhammad Umer Nadeem, Muhammad Junaid Farrukh, Muhammad Mugheera, Inaam Ur Rehman, Asma Fareed Khan, Hamid Saeed, Mohammad Akbar Hossain, Mohamed Raafat, Rozan Mohammad Radwan, Muhammad Shahid Iqbal
Summary: This study assessed the patterns of antimicrobial prescribing and the prevalence of COVID-19 among hospitals in Pakistan during the COVID-19 pandemic. Among 1024 hospitalized patients, 662 (64.64%) received antimicrobials. The most common indications for antimicrobial use were pneumonia (13.3%), central nervous system infections (10.4%), and gastrointestinal indications (10.4%). The study revealed high antimicrobial use in Pakistani hospitals during the COVID-19 pandemic, highlighting the need for multifaceted interventions to enhance rational antimicrobial prescribing, especially for surgical prophylaxis.
Article
Chemistry, Applied
Malik Muhammad Irfan, Shefaat Ullah Shah, Kifayat Ullah Shah, Nicolas Anton, Ysia Idoux-Gillet, Guillaume Conzatti, Elise Perennes, Thierry Vandamme
Summary: The purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using ultrasonication and the impact of different cryoprotectants on its characteristics was investigated. The lyophilised FNS-NS showed spherical shape, a particle size range of 188.6 nm +/- 4.4 to 298.7 nm +/- 4.7, low PDI values, and zeta potential within -38.3 to +53.3 mV. Confocal laser microscopy demonstrated higher cellular internalisation for undecorated FNS-NS compared to its chitosan-decorated counterpart. The lyophilised FNS-NS remained stable for 90 days and the FNS-NS with 15% trehalose showed promising attributes for topical delivery in treating androgenic alopecia.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Immunology
Bushra Arooj, Sajid Asghar, Mohammad Saleem, Syed Haroon Khalid, Muhammad Asif, Tahir Chohan, Ikram Ullah Khan, Hafiz Muhammad Zubair, Hafiza Sidra Yaseen
Summary: This study evaluates the anti-inflammatory, analgesic, and antipyretic properties of Eucalyptus globulus essential oil alone and in combination with flurbiprofen. The combination of 500 + 10 mg/kg of oil-drug showed significantly better effects in all tested properties compared to the individual use of oil or flurbiprofen alone. Furthermore, the combination treatment down-regulated the expression of pro-inflammatory biomarkers (IL-4 and TNF-a).
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nida Rashid, Syed Haroon Khalid, Ikram Ullah Khan, Zunera Chauhdary, Hira Mahmood, Ayesha Saleem, Muhammad Umair, Sajid Asghar
Summary: Curcumin (Cur) entrapped poly(vinyl alcohol) (PVA)/gelatin composite films cross-linked with tannic acid (TA) were developed as bioactive dressings for accelerated wound healing. The films demonstrated excellent mechanical strength, swelling ability, water vapor transmission rate, solubility, and sustained drug release. Moreover, the films exhibited antioxidant and antibacterial effects, promoted wound healing and inhibited inflammation. Therefore, Cur-loaded composite films could serve as an effective delivery system for wound healing.
Article
Chemistry, Multidisciplinary
Yasir Mehmood, Hira Shahid, Muhammad Abbas, Umar Farooq, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel, Mohammed M. Ghoneim
Summary: In this study, an azelastine nasal spray based on nanosuspension was created to improve bioavailability and intranasal absorption. Chondroitin was used as a polymer to prepare the nanosuspension through precipitation. The optimized nanosuspension showed a particle size of 500nm, a polydispersity index of 0.276, and a negative potential of -20mV. Characterization tests and assays were conducted to evaluate the properties and performance of the nanosuspension. The results demonstrated that the azelastine nanosuspension had great potential for the intranasal treatment of allergic rhinitis with improved permeability and bioavailability.
Article
Biotechnology & Applied Microbiology
Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan
Summary: This study evaluated the potential use of moringa gum and carboxymethyl moringa in hydrogel-based dressings for treating cutaneous wounds. The results showed that both moringa gum and carboxymethyl moringa had good biocompatibility and antimicrobial properties. The moringa gum-based hydrogel films exhibited the highest wound contraction rate and could be a potential candidate for wound healing dressings in the future.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Aisha Rashid, Syed Haroon Khalid, Muhammad Irfan, Sajid Asghar, Waleed Y. Rizg, Fahad Y. Sabei, Eman Alfayez, Hanaa Alkharobi, Awaji Y. Safhi, Khaled M. Hosny, Muhammad Sohail Arshad, Ikram Ullah Khan
Summary: This study evaluated the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat (R) RS780-based oral fast disintegrating film (ODF). The composite ODF with RHCl and FBP showed a controlled release of FBP and rapid release of RHCl. The optimized formulation (F2) exhibited higher anti-inflammatory activity and gastroprotective effects compared to pure FBP and other formulations. F2 also showed sustained anti-inflammatory effect and reduced levels of cytokines. The Lycoat (R) RS780-based composite film could be a promising carrier for the co-loading of microencapsulated FBP with RHCl.
Article
Polymer Science
Yasir Mehmood, Hira Shahid, Numera Arshad, Akhtar Rasul, Talha Jamshaid, Muhammad Jamshaid, Usama Jamshaid, Mohammad N. Uddin, Mohsin Kazi
Summary: In this study, hydrogel films containing amikacin were successfully developed by cross-linking chitosan with folic acid, methacrylic acid, ammonium peroxodisulfate, and methylenebisacrylamide. The films demonstrated regulated and controlled release of the antibiotic, as well as effective antibacterial activity and cytocompatibility, showing great potential for wound healing applications.
Article
Polymer Science
Yasir Mehmood, Hira Shahid, Kashif Barkat, Numera Arshad, Akhtar Rasul, Mohammad N. Uddin, Mohsin Kazi
Summary: The purpose of this study was to develop pH-sensitive HPMC/Neocel C19-based interpenetrating polymeric networks (IPNs) for the treatment of various diseases. The IPNs were able to protect the drug and achieve controlled release. The results showed that the IPNs had good thermal stability, low crystallinity, and high amorphousness. The IPNs exhibited pH-responsive characteristics and achieved better swelling and in vitro results at higher pH levels. The drug release was increased at pH 7.4, and in vivo studies showed improved pharmacokinetic properties with hydrogels. The IPN hydrogel also exhibited good blood compatibility.
