Review
Immunology
Alberto Mantovani, Federica Marchesi, Sebastien Jaillon, Cecilia Garlanda, Paola Allavena
Summary: Myeloid cells in tumor tissues, including tumor-associated macrophages and tumor-associated neutrophils, play crucial roles in tumor growth and invasion. In recent years, successful therapeutic approaches have been developed and tested in preclinical cancer models, with some strategies reaching clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak, Mehdi Khoobi
Summary: The tumor microenvironment (TME) plays a critical role in tumor progression and resistance to treatment. Tumor-associated macrophages (TAMs) and hypoxia are important factors in the TME. Catalase and catalase-mimicking compounds can reduce hypoxia and promote TAM polarization, showing potential in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Galina Gabriely, Duanduan Ma, Shafiuddin Siddiqui, Linqing Sun, Nathaniel P. Skillin, Hadi Abou-El-Hassan, Thais G. Moreira, Dustin Donnelly, Andre P. da Cunha, Mai Fujiwara, Lena R. Walton, Amee Patel, Rajesh Krishnan, Stuart S. Levine, Brian C. Healy, Rafael M. Rezende, Gopal Murugaiyan, Howard L. Weiner
Summary: Myeloid suppressor cells expressing LAP on their surface promote tumor growth by stimulating Tregs and inhibiting effector T cells. Blocking TGF-beta can reduce the tolerogenic ability of these cells, leading to slower cancer progression. Additionally, single-cell RNA-Seq analysis reveals distinct immunosuppressive cell subsets with high levels of MHCII and PD-L1 genes. This study provides new insights into the role of LAP(Hi) MCs in tumor growth and potential therapeutic targets for cancer treatment.
Article
Oncology
Joyeon Kang, Doyeon Lee, Kyoung Jin Lee, Jaepil Eric Yoon, Ji-Hee Kwon, Yoojeong Seo, Janghyun Kim, Shin Young Chang, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim
Summary: Metformin has been found to decrease the fractions of MDSCs and M2 macrophages in the tumor microenvironment by activating AMPK and inhibiting mTOR, thus playing a potential role in the prevention and treatment of colorectal cancer.
Article
Biotechnology & Applied Microbiology
Jing Huang, Zhenlin Gu, Yingying Xu, Lei Jiang, Weiguo Zhu, Wanwei Wang
Summary: The study found that CHI3L1 is overexpressed in esophageal cancer tissues and positively correlated with tumor size, as well as with increased expression of macrophage signature genes in the tumor tissues. Additionally, CHI3L1 overexpression may promote macrophage recruitment in esophageal tumor tissues.
Article
Biochemistry & Molecular Biology
Jung Bae Seong, Bokyung Kim, Soyoon Kim, Mi Hye Kim, Young-Ho Park, Youngjeon Lee, Hong Jun Lee, Chang-Won Hong, Dong-Seok Lee
Summary: This study revealed that deficiency of the antioxidant enzyme peroxiredoxin 5 (Prx5) in macrophages induced M2 macrophage polarization, promoting lung cancer progression. However, suppression of ROS generation by N-acetyl cysteine (NAC) inhibited the M2-like polarization of Prx5-deficient macrophages, leading to inhibition of lung cancer cell proliferation and migration, and suppression of tumor growth. These findings suggest that blocking the M2 polarization of macrophages may promote lung cancer regression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Immunology
Angela DeRosa, Avigdor Leftin
Summary: Macrophages play important roles in systemic iron metabolism and immune response. Infiltration and polarization of macrophages in the tumor microenvironment are associated with cancer prognosis, with distinct iron and immune phenotypes observed in tumor associated macrophages in most cancers. Functional connections between dysfunctional iron metabolism and tumor immune response are emerging, providing new insights for immunometabolic precision therapy approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hui Wang, Tian Tian, Jinhua Zhang
Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yi Wang, Kai Conrad Cecil Johnson, Margaret E. Gatti-Mays, Zihai Li
Summary: Immune checkpoint inhibitors have revolutionized oncology, but only a small percentage of patients benefit from them. Understanding the role of myeloid cells in the tumor microenvironment is crucial for differentiating treatment response from non-response. Recent advancements have provided insights into the heterogeneity and function of myeloid cells, and strategies targeting these cells are being explored in preclinical and clinical settings.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Oncology
Xinyu Cheng, Huilan Wang, Zhongyu Wang, Bo Zhu, Haixia Long
Summary: Tumor-associated myeloid cells (TAMCs) are crucial immune cell populations in the tumor microenvironment and have a significant impact on immune checkpoint blockade efficacy. Understanding the origin of TAMCs is essential for determining their functional diversity and developing cancer immunotherapy strategies. This review article provides an overview of recent research progress on evaluating the heterogeneity of TAMC origins. It also summarizes major therapeutic strategies targeting TAMCs with diverse sources, shedding light on their implications for cancer immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Huogang Wang, Mingo M. H. Yung, Hextan Y. S. Ngan, Karen K. L. Chan, David W. Chan
Summary: Metastasis, driven by tumor-associated macrophages (TAMs), is a key factor in most cancer deaths, with TAMs playing a crucial role in influencing tumor metastasis and treatment outcomes by polarizing metabolism patterns. Tumor cell-driven TAMs in the tumor microenvironment promote tumor metastasis and are associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Weichuan Luo, John V. Napoleon, Fenghua Zhang, Yong Gu Lee, Bingbing Wang, Karson S. Putt, Philip S. Low
Summary: CAR T cell therapies have shown great effectiveness in treating hematopoietic cancers, but their success in solid tumors has been limited. This study investigates the role of immunosuppressive tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in CAR T cell therapy and proposes a method to enhance their efficacy by reprogramming these myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jiashu Han, Luochu Dong, Mengwei Wu, Fei Ma
Summary: Immunotherapy has revolutionized tumor treatment, but many patients still do not respond due to the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play a crucial role in shaping this microenvironment and interacting with intratumoral T cells. However, the heterogeneity and plasticity of TAMs make it challenging to target specific factors and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Ao Chen, Fan Yang, Jing Kuang, Yuan Xiong, Bo-Bin Mi, Ying Zhou, Jing-Jing Hu, Shu-Jun Song, Tao Wan, Zhong-Zhong Wan, Hong-Yang Huang, Xin-Run Li, Wen Song, Wen-Xiu Qiu
Summary: A nanoplatform was constructed to reverse tumor acidosis and hypoxia through alkali and oxygen generation triggered by tumor acidosis, polarizing tumor-associated macrophages to anti-tumor M1 phenotype macrophages and enhancing tumor immune response. Furthermore, under regional light irradiation, reactive oxygen species produced by photosensitizers in the nanoplatform could increase the immunogenicity of tumors, transitioning tumors from immunosuppressive cold tumors to immunogenic hot tumors and amplifying the effect of immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Claire L. Ihle, Meredith D. Provera, Desiree M. Straign, E. Erin Smith, Susan M. Edgerton, Adrie Van Bokhoven, M. Scott Lucia, Philip Owens
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Claire L. Ihle, Philip Owens
MOLECULAR CARCINOGENESIS
(2020)
Article
Oncology
Michelle M. Williams, Jessica L. Christenson, Kathleen I. O'Neill, Sabrina A. Hafeez, Claire L. Ihle, Nicole S. Spoelstra, Jill E. Slansky, Jennifer K. Richer
Summary: The study demonstrates that utilizing miR-200c can drive TNBC cells toward a more epithelial state and inhibit the growth of mouse mammary carcinoma cells. Upregulation of cytokines such as GM-CSF by miR-200c promotes M1 anti-tumor macrophage polarization, predicting a more favorable overall survival for TNBC patients. This suggests further research on cytokine-based therapies to limit disease recurrence in aggressive TNBC.
Review
Endocrinology & Metabolism
Blayne A. Sarazin, Claire L. Ihle, Philip Owens, Maureen E. Lynch
Summary: This review provides an overview of the impacts of mechanical stimuli on metastatic tumor-induced bone disease, focusing on the role of osteocytes in the skeleton. Exercise and controlled mechanical loading have anabolic effects on bone tissue, and also have anti-tumorigenic properties.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Endocrinology & Metabolism
Desiree M. Straign, Claire L. Ihle, Meredith D. Provera, Philip Owens
Summary: Prostate cancer bone metastases are common and often lead to painful skeletal events, with the BMP and TGF beta signaling pathways showing distinct effects in lytic or blastic bone lesions. Inhibiting BMP with DMH1 treatment restricts colonization of cancer cells in bone and preserves bone health. This suggests that profiling bone lesions in metastatic prostate cancer can help identify therapeutic targets to improve treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Meredith D. Provera, Desiree M. Straign, Parvanee Karimpour, Claire L. Ihle, Philip Owens
Summary: Prostate cancer is a common cancer in men and a leading cause of male deaths. This study highlights the importance of the bone morphogenetic protein (BMP) pathway in metastatic prostate cancer and its potential for personalized precision oncology.