Review
Biotechnology & Applied Microbiology
Leon Kemper, Andreas Hensel
Summary: Campylobacter jejuni, causing severe enteritis, has unique features and adapts effectively to environmental conditions. The review summarizes the strategies of C. jejuni for host-pathogen interaction, providing insights for future drug development.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Microbiology
Feng Kong, Li Yang
Summary: As sessile organisms, plants have evolved physical barriers, chemical defenses, and inducible immunity to defend against pathogens. Pathogens, on the other hand, use various strategies to colonize and cause diseases. This review focuses on understanding the molecular mechanisms of pathogen-induced changes in plant development and how pathogens shape plant development to increase their virulence and cause diseases. Research in this area may provide novel insights into plant disease control.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Charmaine Retanal, Brianna Ball, Jennifer Geddes-McAlister
Summary: This review focuses on the role of post-translational modifications (PTMs) in fungal pathogens, such as Candida spp., Aspergillus spp., and Cryptococcus spp., in adapting to host environments, manipulating host immune responses, and developing resistance to antifungal drugs. It provides a critical evaluation of current knowledge, addresses key questions in understanding the complex roles of PTMs in fungal pathogens, and presents research opportunities for uncovering new therapeutic strategies.
Article
Plant Sciences
M. Nandakumar, P. Malathi, A. R. Sundar, C. P. Rajadurai, Manuel Philip, R. Viswanathan
Summary: The study identified specific roles of sugarcane microRNAs during compatible and incompatible interactions with the red rot pathogen Colletotrichum falcatum, shedding light on how these miRNAs regulate their gene targets and elucidating the molecular mechanism of sugarcane defense response to C. falcatum for the first time.
PLANT CELL REPORTS
(2021)
Article
Ecology
Lia Schlippe Justicia, Martin Mayer, Richard Shine, Cathy Shilton, Gregory P. Brown
Summary: Coevolutionary host-parasite arms races can be disrupted by biological invasions, affecting both host and parasite densities, as well as their traits. The spread of cane toads and their parasitic lungworm across tropical Australia provides an opportunity to study a perturbed host-parasite system. Infection success was highest when toads from long-established populations were exposed to lungworms from close to the invasion front, suggesting increased parasite infectivity and host resistance over the course of invasion. Most virulence/tolerance traits have not consistently increased or decreased during invasion. Higher parasite burdens were associated with increased feeding performance in toads and faster growth in lungworms, suggesting host manipulation by the parasite.
ECOLOGY AND EVOLUTION
(2022)
Review
Immunology
Yanjian Li, Hailong Li, Tianshu Sun, Chen Ding
Summary: Fungal diseases are on the rise globally due to factors such as increased immunocompromised patients, aging populations, and the COVID-19 pandemic. Mass spectrometry-based proteomics is a novel approach to understanding fungal pathogenicity and host-pathogen interactions, revealing the importance of protein and posttranslational modifications in the progression of fungal diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Jingjing Luo, Lidong Wang, Lei Song, Zhao-Qing Luo
Summary: Ubiquitination is a commonly used post-translational modification in eukaryotic cells that plays a crucial role in immune responses. Pathogens like Legionella pneumophila utilize ubiquitin signaling to modulate host cell processes, support replication, and manipulate ubiquitin signaling through effector proteins.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Immunology
Pavla Stojkova, Petra Spidlova
Summary: HU protein, a member of the nucleoid-associated protein family, plays a crucial role in regulating bacterial virulence, pathogenesis, and survival. Recent studies suggest that HU protein may not only exist inside bacteria but also be secreted outside bacteria and even enter host cells. However, its specific role in host cells is still not well understood and further research is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biology
Hajarooba Gnanagobal, Javier Santander
Summary: This review provides a comprehensive analysis of the interactions between marine Gram-positive pathogens and fish hosts, which cause economic losses in global marine fish aquaculture. Understanding these host-pathogen interactions is crucial for developing effective prophylactic measures and treatments.
Article
Microbiology
Jeffrey K. J. Cheng, Meera Unnikrishnan
Summary: C. difficile is the main cause of nosocomial infective diarrhea. It exploits the intestinal microbiota and host epithelium for infection and persistence. This review discusses the virulence factors of C. difficile and their interactions with the gut, as well as the immune responses triggered during C. difficile infection.
Article
Biochemistry & Molecular Biology
Benjamin Petre, Mauricio P. Contreras, Tolga O. Bozkurt, Martin H. Schattat, Jan Sklenar, Sebastian Schornack, Ahmed Abd-El-Haliem, Roger Castells-Graells, Rosa Lozano-Duran, Yasin F. Dagdas, Frank L. H. Menke, Alexandra M. E. Jones, Jack H. Vossen, Silke Robatzek, Sophien Kamoun, Joe Win
Summary: By transiently expressing RXLR effectors of the potato blight pathogen Phytophthora infestans in Nicotiana benthamiana leaves, an effector-host protein interactome matrix was generated, revealing over 35 biological processes potentially targeted by P. infestans. This study provides a valuable resource for functional studies of P. infestans effectors and effector-targeted host processes.
Article
Microbiology
Alexandra Imre, Renato Kovacs, Kitti Pazmandi, Daniel Nemes, Agnes Jakab, Tunde Fekete, Hanna Viktoria Racz, Ilona Doczi, Ildiko Bacskay, Attila Gacser, Karoly Kovacs, Laszlo Majoros, Zoltan Farkas, Istvan Pocsi, Walter P. Pfliegler
Summary: Research has found that Saccharomyces yeast probiotics may possess potential pathogenic characteristics and display new traits as they evolve within the host. While there are some differences, the yeast does not show significant pathogenicity in the host and its entry into the bloodstream is not active. These findings highlight the need for a more thorough assessment of probiotic use.
Article
Biotechnology & Applied Microbiology
Xiaoye Liang, Tong-Tong Pei, Zeng-Hang Wang, Weiliang Xiong, Li-Li Wu, Ping Xu, Shuangjun Lin, Tao G. Dong
Summary: The Type VI Secretion System (T6SS) is utilized by Gram-negative bacteria for interspecies interaction. This study identified a lysozyme-like effector TseP in Aeromonas dhakensis, showcasing its cell wall-lysing activities and T6SS dependency. Inactivating TseP and two other effectors led to the creation of a detoxified T6SS-active strain for potential protein delivery to various recipient cells.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Parasitology
M. Motiur R. Chowdhury, Amitav Roy, Kalle Auvinen, Katja Pulkkinen, Hanna Suonia, Jouni Taskinen
Summary: This study compared mortality induced by a fatal bacterial pathogen in brown trout infected with glochidia from freshwater pearl mussels to uninfected controls. Surprisingly, the glochidial infection increased the fish host's resistance to the bacterial infection, prolonging survival time compared to uninfected fish. Evidence suggests a potential mechanism involving enhanced immunity or changes in gill structure, providing important insights into host-parasite interactions and ecosystem services.
PARASITOLOGY RESEARCH
(2021)