The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

(2020) Bo Hu et al.   NATURE

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium–Induced Colitis

(2019) Christa Park et al.   JOURNAL OF IMMUNOLOGY

Anatomical, Physiological, and Functional Diversity of Adipose Tissue

(2018) Rachel K. Zwick et al.   Cell Metabolism

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa

(2018) Madeleine D. Hu et al.   JOURNAL OF IMMUNOLOGY

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

(2018) Joannie M. Allaire et al.   TRENDS IN IMMUNOLOGY

Decrease in αβ/γδ T-cell ratio is accompanied by a reduction in high-fat diet–induced weight gain, insulin resistance, and inflammation

(2018) Gwenaëlle Le Menn et al.   FASEB JOURNAL

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

(2018) Camille Khairallah et al.   Frontiers in Immunology

Dermal γδ T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity

(2017) Xiaodong Jiang et al.   PLoS One

Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin

(2016) Brice E. Keyes et al.   CELL

The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation

(2015) Felix M. Wensveen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice

(2015) Karen L. Edelblum et al.   GASTROENTEROLOGY

Coxsackie and Adenovirus Receptor Is Increased in Adipose Tissue of Obese Subjects: A Role for Adenovirus Infection?

(2015) Marta Serrano et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NKG2D-Dependent Activation of Dendritic Epidermal T Cells in Contact Hypersensitivity

(2015) Morten M. Nielsen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Interplay between the immune system and adipose tissue in obesity

(2014) Mark A Exley et al.   JOURNAL OF ENDOCRINOLOGY

IL-15 Does Not Affect IEL Development in the Thymus but Regulates Homeostasis of Putative Precursors and Mature CD8  + IELs in the Intestine

(2014) Y.-G. Lai et al.   JOURNAL OF IMMUNOLOGY

IL-1 -Dependent Activation of Dendritic Epidermal T Cells in Contact Hypersensitivity

(2014) M. M. Nielsen et al.   JOURNAL OF IMMUNOLOGY

Skin-Resident T Cells Sense Ultraviolet Radiation-Induced Injury and Contribute to DNA Repair

(2014) A. S. MacLeod et al.   JOURNAL OF IMMUNOLOGY

γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice

(2014) Pooja Mehta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Small Intestinal Intraepithelial TCRγδ+ T Lymphocytes Are Present in the Premature Intestine but Selectively Reduced in Surgical Necrotizing Enterocolitis

(2014) Jörn-Hendrik Weitkamp et al.   PLoS One

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

(2013) Tamara Tchkonia et al.   Cell Metabolism

Dendritic epidermal T cells regulate skin antimicrobial barrier function

(2013) Amanda S. MacLeod et al.   JOURNAL OF CLINICAL INVESTIGATION

Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function

(2013) T F Meehan et al.   Mucosal Immunology

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

(2012) Deborah A. Witherden et al.   IMMUNITY

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

Involvement of an NKG2D Ligand H60c in Epidermal Dendritic T Cell-Mediated Wound Repair

(2012) S. Yoshida et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Dendritic Epidermal    T Cell Ligands Are Rapidly and Locally Expressed by Keratinocytes following Cutaneous Wounding

(2012) H. K. Komori et al.   JOURNAL OF IMMUNOLOGY

Body-barrier surveillance by epidermal γδ TCRs

(2012) Grzegorz Chodaczek et al.   NATURE IMMUNOLOGY

Adipose tissue: friend or foe?

(2012) Mohamed Hassan et al.   Nature Reviews Cardiology

Dynamic migration of    intraepithelial lymphocytes requires occludin

(2012) K. L. Edelblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

(2011) A Shuster et al.   BRITISH JOURNAL OF RADIOLOGY

Functions of skin-resident γδ T cells

(2011) Amanda S. MacLeod et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity

(2011) Kristen R. Taylor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene

(2011) Ahmad Pazirandeh et al.   PLoS One

   intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface

(2011) A. S. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of γδ region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry

(2010) A. BUCHT et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mucosal T cells in gut homeostasis and inflammation

(2010) Femke van Wijk et al.   Expert Review of Clinical Immunology

Epidermal T Cells and Wound Healing

(2010) W. L. Havran et al.   JOURNAL OF IMMUNOLOGY

Differential Roles of IL-2-Inducible T Cell Kinase-Mediated TCR Signals in Tissue-Specific Localization and Maintenance of Skin Intraepithelial T Cells

(2010) M. Xia et al.   JOURNAL OF IMMUNOLOGY

CCR10 Is Important for the Development of Skin-Specific   T Cells by Regulating Their Migration and Location

(2010) Y. Jin et al.   JOURNAL OF IMMUNOLOGY

Intra- and Intercompartmental Movement of    T Cells: Intestinal Intraepithelial and Peripheral    T Cells Represent Exclusive Nonoverlapping Populations with Distinct Migration Characteristics

(2010) V. Chennupati et al.   JOURNAL OF IMMUNOLOGY

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

T-Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet-Induced Obesity in C57BL/6 Mice

(2010) Katherine J. Strissel et al.   Obesity

γδ T Cells Are Reduced and Rendered Unresponsive by Hyperglycemia and Chronic TNFα in Mouse Models of Obesity and Metabolic Disease

(2010) Kristen R. Taylor et al.   PLoS One

Embryonic trafficking of    T cells to skin is dependent on E/P selectin ligands and CCR4

(2010) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial    T Cell Activation

(2010) D. A. Witherden et al.   SCIENCE

The Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3K

(2010) P. Verdino et al.   SCIENCE

Invariant NKT cells and CD1d+cells amass in human omentum and are depleted in patients with cancer and obesity

(2009) Lydia Lynch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A role for human skin–resident T cells in wound healing

(2009) Antoine Toulon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge:    Intraepithelial Lymphocytes of the Small Intestine Are Not Biased toward Thymic Antigens

(2009) K. D. C. Jensen et al.   JOURNAL OF IMMUNOLOGY

Costimulation of Dendritic Epidermal    T Cells by a New NKG2D Ligand Expressed Specifically in the Skin

(2009) M. I. Whang et al.   JOURNAL OF IMMUNOLOGY

Trans-Presentation of IL-15 by Intestinal Epithelial Cells Drives Development of CD8   IELs

(2009) L. J. Ma et al.   JOURNAL OF IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

T-lymphocyte Infiltration in Visceral Adipose Tissue

(2008) Ulrich Kintscher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease

(2008) Govind Bhagat et al.   JOURNAL OF CLINICAL INVESTIGATION

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY