TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity

TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding

(2019) Guey-Ying Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral BDNF/TrkB protein expression is decreased in Parkinson’s disease but not in Essential tremor

(2019) Yixian Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

MEST induces Twist-1-mediated EMT through STAT3 activation in breast cancers

(2019) Min Soo Kim et al.   CELL DEATH AND DIFFERENTIATION

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

(2019) Jie Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

(2019) Zhi-Hao Wang et al.   Cell Reports

Improvement of BDNF signalling by P42 peptide in Huntington's disease

(2018) Simon Couly et al.   HUMAN MOLECULAR GENETICS

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

(2018) Hongyu Zhang et al.   Nature Communications

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease

(2017) Seong Su Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15 Ink4B

(2016) Xin-Hua Feng et al.   MOLECULAR CELL

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer

(2016) Min Soo Kim et al.   Scientific Reports

TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression

(2015)   MOLECULES AND CELLS

Structural determinants of Smad function in TGF-β signaling

(2015) Maria J. Macias et al.   TRENDS IN BIOCHEMICAL SCIENCES

Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer

(2015) Min Soo Kim et al.   Oncotarget

Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition

(2014) Rik Derynck et al.   CURRENT OPINION IN CELL BIOLOGY

EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons

(2013) Dirk Puehringer et al.   NATURE NEUROSCIENCE

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Characterization of Human Cancer-Derived TRKB Mutations

(2011) Thomas R. Geiger et al.   PLoS One

Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties

(2009) Jason A. Luther et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

A Twist-Snail Axis Critical for TrkB-Induced Epithelial-Mesenchymal Transition-Like Transformation, Anoikis Resistance, and Metastasis

(2009) M. A. Smit et al.   MOLECULAR AND CELLULAR BIOLOGY