Article
Cell Biology
Lei Lang, Jing Tao, Chaomei Yang, Wei Li
Summary: miR-4731-5p inhibits glycolysis and epithelial-mesenchymal transition (EMT) in breast cancer cells by suppressing PAICS-induced phosphorylation of FAK.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Cristina Lungulescu, Valentina Ghimpau, Dan Ionut Gheonea, Daniel Sur, Cristian Virgil Lungulescu
Summary: This systematic review investigates the expression and function of neuropilin-2 (NRP-2) in colorectal cancer. The majority of studies suggest that NRP-2 is highly expressed in colorectal cancer cells compared to normal colonic mucosa. The presence of NRP-2 is associated with epithelial-mesenchymal transition and metastatic progression in cancer.
Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Article
Gastroenterology & Hepatology
Xiaoling Ding, Jie Zhang, Ziqin Feng, Qianru Tang, Xiaorong Zhou
Summary: In colorectal cancer, the downregulation of miR-137-3p and upregulation of KDM1A are associated with disease progression. Inhibiting miR-137-3p leads to increased KDM1A expression and promotes CRC cell invasiveness. Targeting KDM1A inhibits CRC cell migration and invasion by regulating the EMT process.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Cell Biology
Taiyuan Li, Cheng Tan, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei
Summary: miR-144-3p is down-regulated in colorectal adenocarcinoma, and its low expression is associated with adverse clinicopathologic characteristics and poor prognosis. By targeting ZEB1/2, miR-144-3p can inhibit cell proliferation, invasion, and EMT in CRA.
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Tianying Zheng, Wenfei Han, Aijun Wang, Yonggang Wang
Summary: This study reveals that miR-128-3p inhibits epithelial-mesenchymal transition, invasion, and migration of pancreatic cancer cells by targeting ZEB1.
Article
Multidisciplinary Sciences
Enoch Kang, Sung Cheol Jung, Soo Kyung Nam, Yujun Park, Soo Hyun Seo, Kyoung Un Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
Summary: This study evaluated the prognostic potential of EMT-related miRNAs as biomarkers in colorectal cancer (CRC). The results showed that the tissue expression of miR-200c-3p and the plasma levels of miR-1290 were associated with poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke, Wataru Takaki, Jun Kiuchi, Hiroki Shimizu, Yusuke Yamamoto, Shuhei Komatsu, Atsushi Shiozaki, Yoshiaki Kuriu, Eigo Otsuji
Summary: In this study, miR-4442 was identified as a potential biomarker for predicting early recurrence in colorectal cancer. The level of miR-4442 was associated with the risk of recurrence and increased with earlier recurrence dates. Furthermore, miR-4442 played a role in promoting the proliferative, migratory, and invasive activities of colorectal cancer cells by directly targeting the messenger RNA of RBMS1, thus regulating epithelial-mesenchymal transition (EMT) in colorectal cancer.
Article
Medicine, Research & Experimental
Ke-Da Yang, Ying Wang, Fan Zhang, Bai-Hua Luo, De-Yun Feng, Zhi-Jun Zeng
Summary: This study found that circN4BP2L2 acts as an oncogene in CRC, promoting tumor growth and metastasis by regulating the miR-340-5p/CXCR4 axis. The authors revealed a novel mechanism in the ceRNA regulatory network for CRC progression and identified a potential therapeutic target for CRC treatment.
LABORATORY INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Guanghong Du, Xuelian Yu, Yun Chen, Wangting Cai
Summary: MiR-1-3p suppresses colorectal cancer cell proliferation and metastasis by regulating YWHAZ-mediated EMT, which may support a novel therapeutic strategy for CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
Summary: The study showed that the polycomb protein BMI-1 plays a crucial role in colorectal cancer liver metastasis, and knocking down BMI-1 can reduce liver metastasis, suggesting it as a potential therapeutic target.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Letter
Oncology
Rachael M. Orlandella, Jennifer R. Bail, Michael Behring, Karina I. Halilova, Roman B. Johnson, Victoria Williams, Lyse A. Norian, Wendy Demark-Wahnefried
Article
Oncology
Sumit Agarwal, Michael Behring, Hyung-Gyoon Kim, Darshan S. Chandrashekar, Balabhadrapatruni V. S. K. Chakravarthi, Nirzari Gupta, Prachi Bajpai, Amr Elkholy, Sameer Al Diffalha, Pran K. Datta, Martin J. Heslin, Sooryanarayana Varambally, Upender Manne
MOLECULAR ONCOLOGY
(2020)
Article
Immunology
Justin T. Gibson, Rachael M. Orlandella, William J. Turbitt, Michael Behring, Upender Manne, Robert E. Sorge, Lyse A. Norian
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Oncology
Andrew Brane, Michael Behring, Karina I. Halilova, Lyse Norian
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Mansoor Saleh, Darshan Shimoga Chandrashekar, Sayed Shahin, Sumit Agarwal, Hyung-Gyoon Kim, Michael Behring, Asim Jamal Shaikh, Zahir Moloo, Isam-Eldin A. Eltoum, Clayton Yates, Sooryanarayana Varambally, Upender Manne
Summary: This study aimed to identify transcriptome differences in TNBC patients of Bantu origin from Kenya compared to African-American and Caucasian TNBC patients. Analysis revealed 45 KE TNBC-specific genes associated with pathways such as apoptosis, cell proliferation, and Wnt signaling. These findings suggest potential molecular determinants and biomarkers specific to KE TNBC patients.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Michael Behring, Yuanfan Ye, Amr Elkholy, Prachi Bajpai, Sumit Agarwal, Hyung-Gyoon Kim, Akinyemi I. Ojesina, Howard W. Wiener, Upender Manne, Sadeep Shrestha, Ana I. Vazquez
Summary: In this study, differential expression of LM22 signature genes was used to classify immune-rich and immune-poor breast tumors, with specific genes such as CCL19 and CXCL9 showing consistent differences between the two groups. Overexpression of certain genes like CHI3L2 and FES was observed in triple negative breast cancers among immune-rich tumors. Immune-rich tumors displayed significant upregulation of genes/pathways, while immune-poor tumors did not show any identified alterations in gene expression.
Article
Oncology
Sumit Agarwal, Farrukh Afaq, Prachi Bajpai, Hyung-Gyoon Kim, Amr Elkholy, Michael Behring, Darshan Shimoga Chandrashekar, Sameer Al Diffalha, Moh'd Khushman, Shajan P. Sugandha, Sooryanarayana Varambally, Upender Manne
Summary: This study demonstrates that DCZ0415, a small molecule targeting TRIP13, inhibits the progression and metastasis of colorectal cancer (CRC) by targeting multiple signaling pathways, activating anti-tumor immune response, and reducing the expression of key proteins associated with tumor growth and metastasis.
MOLECULAR ONCOLOGY
(2022)
Article
Medicine, General & Internal
Chandrakumar Shanmugam, Michael Behring, Vishwas Luthra, Sixto M. Leal, Sooryanarayana Varambally, George J. Netto, Upender Manne
Summary: Accurate detection of SARS-CoV-2 is necessary to control the COVID-19 pandemic. The study reviewed 85 studies from five regions and identified issues in the early-phase diagnosis of COVID-19. Serological testing can complement and reduce false negative results from RT-PCR.
Article
Oncology
Sarah Obuya, Amr Elkholy, Nagavardhini Avuthu, Michael Behring, Prachi Bajpai, Sumit Agarwal, Hyung-Gyoon Kim, Nefertiti El-Nikhely, Pamela Akinyi, James Orwa, Farrukh Afaq, Mohammed Abdalla, Anwar Michael, Mohamed Farouk, Lori Brand Bateman, Mona Fouad, Mansoor Saleh, Chittibabu Guda, Upender Manne, Waleed Arafat
Summary: This study focused on analyzing the gut microbiome of Kenyan CRC patients and found differences in microbial metabolic profiles compared to healthy individuals. Particularly, the microbiome composition was different for patients under 40 years of age.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Prachi Bajpai, Nilam Sanjib Banerjee, Dianne W. Moore, Hyung-Gyoon Kim, Farrukh Afaq, Carlo M. Contreras, Martin J. Heslin, Vishnu B. Reddy, Shajan Peter, Sooryanarayana Varambally, Sameer Al Diffalha, Upender Manne
Summary: This study developed an improved 3D tumor organoid model for efficient evaluation of new cancer drugs. By utilizing patient-derived xenografts, this model demonstrated promising results in response to the investigational drug Navitoclax (ABT-263).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sumit Agarwal, Farrukh Afaq, Prachi Bajpai, Michael Behring, Hyung-Gyoon Kim, Amith Varambally, Darshan S. Chandrashekar, Shajan Peter, Sameer Al Diffalha, Moh 'd Khushman, Andreas Seeber, Sooryanarayana Varambally, Upender Manne
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Chirag Patel, Michael Behring, Sameer Al Diffalha, Deepti Dhall, Goo Lee, Chandrakumar Shanmugam, William E. Grizzle, Upender Manne
Summary: This study compared the prognostic value of mucinous adenocarcinomas (MCAs) and non-mucinous adenocarcinomas (NMCAs) and found that rectal MCAs have a poor prognosis.