Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization

A Multi-Institutional Study to Evaluate Automated Whole Slide Scoring of Immunohistochemistry for Assessment of Programmed Death-Ligand 1 (PD-L1) Expression in Non–Small Cell Lung Cancer

(2019) Clive R. Taylor et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Programmed death ligand 1 immunohistochemistry in non-small cell lung carcinoma

(2019) Sylvie Lantuejoul et al.   Journal of Thoracic Disease

Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade

(2019) Steve Lu et al.   JAMA Oncology

Comparison of continuous measures across diagnostic PD-L1 assays in non-small cell lung cancer using automated image analysis

(2019) Moritz Widmaier et al.   MODERN PATHOLOGY

Validation of the systematic scoring of immunohistochemically stained tumour tissue microarrays using QuPath digital image analysis

(2018) Maurice B Loughrey et al.   HISTOPATHOLOGY

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

(2018) Matthew P. Humphries et al.   Journal of Oncology

Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities

(2018) Matthew P. Humphries et al.   Journal of Thoracic Oncology

PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data

(2017) Pedro N Aguiar et al.   Immunotherapy

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

(2017) Peter Bankhead et al.   LABORATORY INVESTIGATION

Implications of the tumor immune microenvironment for staging and therapeutics

(2017) Janis M Taube et al.   MODERN PATHOLOGY

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

(2016) Geoffrey T Gibney et al.   LANCET ONCOLOGY

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy

(2014) J. M. Taube et al.   CLINICAL CANCER RESEARCH

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

A standardized framework for the validation and verification of clinical molecular genetic tests

(2010) Christopher J Mattocks et al.   EUROPEAN JOURNAL OF HUMAN GENETICS