Transmission of ALS pathogenesis by the cerebrospinal fluid

Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology

(2019) Silvia Pozzi et al.   JOURNAL OF CLINICAL INVESTIGATION

CSF chitinase proteins in amyotrophic lateral sclerosis

(2019) Alexander G Thompson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders

(2019) Alessandro Didonna et al.   Molecular Neurodegeneration

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

(2019) Elaine Y. Liu et al.   Cell Reports

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD

(2019) Britt A. Berning et al.   Frontiers in Neuroscience

Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

(2019) Benjamin Gille et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

(2019) Ernesto Manzo et al.   eLife

TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1

(2019) Jen-Fei Chu et al.   Cell Reports

Energy metabolism in ALS: an underappreciated opportunity?

(2018) Tijs Vandoorne et al.   ACTA NEUROPATHOLOGICA

Sporadic amyotrophic lateral sclerosis (SALS) – skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model

(2018) Shruthi Shanmukha et al.   Disease Models & Mechanisms

Towards a TDP-43-Based Biomarker for ALS and FTLD

(2018) Emily Feneberg et al.   MOLECULAR NEUROBIOLOGY

La infusión intracerebroventricular prolongada de líquido cefalorraquídeo procedente de pacientes con esclerosis lateral amiotrófica provoca cambios histológicos en el cerebro y la médula espinal de la rata similares a los hallados en la enfermedad

(2018) U. Gómez-Pinedo et al.   NEUROLOGIA

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

(2018) Matthew D. Cykowski et al.   Acta Neuropathologica Communications

Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors

(2018) Aidong Yuan et al.   Translational Psychiatry

Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin

(2018) Vincent Picher-Martel et al.   MOLECULAR NEUROBIOLOGY

Amyotrophic lateral sclerosis — a multisystem neurodegenerative disorder

(2018) Murray Grossman   Nature Reviews Neurology

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

(2017) Pooja-Shree Mishra et al.   Journal of Neuroinflammation

Genetic screening in sporadic ALS and FTD

(2017) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts

(2017) Hejer Boutej et al.   Cell Reports

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins

(2016) Antonia Ratti et al.   JOURNAL OF NEUROCHEMISTRY

Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients

(2016) Pooja-Shree Mishra et al.   Journal of Neuroinflammation

Electrophysiological characterization of Nsc-34 cell line using Microelectrode Array

(2016) K.R. Sabitha et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

From animal models to human disease: a genetic approach for personalized medicine in ALS

(2016) Vincent Picher-Martel et al.   Acta Neuropathologica Communications

Amyotrophic lateral sclerosis: Is the spinal fluid pathway involved in seeding and spread?

(2015) Richard Smith et al.   MEDICAL HYPOTHESES

Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients Induces Mitochondrial and Lysosomal Dysfunction

(2015) Aparna Sharma et al.   NEUROCHEMICAL RESEARCH

Brain glucose metabolism in an animal model of depression

(2015) J. Detka et al.   NEUROSCIENCE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

Risk factors for amyotrophic lateral sclerosis

(2015) Fang Fang et al.   Clinical Epidemiology

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

(2015) Jacqueline C Mitchell et al.   Acta Neuropathologica Communications

Inflammation Induces TDP-43 Mislocalization and Aggregation

(2015) Ana Sofia Correia et al.   PLoS One

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes

(2014) Janet Cady et al.   ANNALS OF NEUROLOGY

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

Role of VEGF and VEGFR2 Receptor in Reversal of ALS-CSF Induced Degeneration of NSC-34 Motor Neuron Cell Line

(2014) K. Vijayalakshmi et al.   MOLECULAR NEUROBIOLOGY

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis

(2014) N.-M. Gruning et al.   Open Biology

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

(2014) Kathleen S. Tatem et al.   Jove-Journal of Visualized Experiments

Skeletal muscle PGC-1  controls whole-body lactate homeostasis through estrogen-related receptor  -dependent activation of LDH B and repression of LDH A

(2013) S. Summermatter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

(2012) M. Lalancette-Hebert et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage

(2010) Xiuling Xu et al.   BLOOD CELLS MOLECULES AND DISEASES

Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia

(2010) Terence A. Agbor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity

(2010) Satoshi Yamashita et al.   JOURNAL OF NEUROCHEMISTRY

Galectin-3 Is a Candidate Biomarker for Amyotrophic Lateral Sclerosis: Discovery by a Proteomics Approach

(2010) Jian-Ying Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

(2009) Andrew Filer et al.   ARTHRITIS AND RHEUMATISM

Altered neuronal activities in the motor cortex with impaired motor performance in adult rats observed after infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients

(2009) R. Sankaranarayani et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondrial dysfunction in amyotrophic lateral sclerosis

(2009) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Cerebrospinal Fluid from sporadic Amyotrophic Lateral Sclerosis patients induces degeneration of a cultured motor neuron cell line

(2009) K. Vijayalakshmi et al.   BRAIN RESEARCH

The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis

(2008) Michael J. Strong   Amyotrophic Lateral Sclerosis

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY