Article
Medicine, General & Internal
Tao Yang, Lizheng Hao, Xinyu Yang, Changyong Luo, Guomi Wang, Caroline Lin Cai, Shuo Qi, Zhong Li
Summary: This study evaluated the association between pretreatment dNLR and prognosis of patients with NSCLC treated with ICIs through systematic review and meta-analysis. The results showed that higher dNLR levels significantly predicted poor overall survival and progression-free survival in NSCLC patients.
Review
Medicine, General & Internal
Shufei Yu, Shuyang Zhang, Haiyan Xu, Guangjian Yang, Fei Xu, Liang Yang, Duo Chen, Guangyu An, Yan Wang
Summary: This meta-analysis investigates the efficacy of immune checkpoint inhibitors (ICIs) compared to chemotherapy in lung cancer patients with liver or brain metastases. The results show that ICIs are more effective than chemotherapy in these patients, with less benefit observed in patients with liver metastases and greater benefit observed in patients with brain metastases, specifically in non-small cell lung cancer patients.
Review
Medicine, General & Internal
Amy L. Shaver, Nikita Nikita, Swapnil Sharma, Daniel S. Lefler, Atrayee Basu-Mallick, Jennifer M. Johnson, Meghan L. Butryn, Grace Lu-Yao
Summary: This study aims to investigate the influence of sex on the outcomes of cancer patients receiving ICI therapy and identify any knowledge gaps in this field.
Review
Medicine, General & Internal
Xuemei Xiang, Yunming Li, Xiaoguang Yang, Wang Guo, Pengfei Zhou
Summary: This study aims to evaluate the predictive value of tumour mutation burden (TMB) in the efficacy of immune checkpoint inhibitors (ICIs). The study will compare the efficacy of ICIs between patients with high TMB and low TMB, and assess their impact on overall survival, progression-free survival, and objective response rate. Subgroup analysis, sensitivity analysis, heterogeneity analysis, and publication bias will also be conducted.
Article
Oncology
Mikail Gogenur, Tina Fransgard, Tyra Grove Krause, Lau Caspar Thygesen, Ismail Gogenur
Summary: A study conducted on 21,462 patients undergoing curative surgery for solid cancers found that receiving an influenza vaccine postoperatively was associated with a significant decrease in overall mortality and cancer-specific mortality, especially when the vaccine was administered within 30 days post-surgery.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Aurore Dumond, Etienne Brachet, Jerome Durivault, Valerie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grepin, Gilles Pages
Summary: Inhibition of NRPs is a promising treatment for mccRCC patients in therapeutic impasses, and NRPa-308 presents as a relevant hit for this purpose, showing efficient inhibition of cell metabolism and migration/invasion.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Medicine, General & Internal
Miaoqi Chen, Ridesh Raj, Louis Fox, Charlotte Louise Moss, Gincy George, Sophia N. Karagiannis, Deborah Enting, Magdalene Joseph, Nicola Peat, Beth Russell, Mieke Van Hemelrijck
Summary: This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility, and the potential underlying biological mechanisms responsible for their effects on cancer immunotherapy using immune checkpoint inhibitors (ICIs).
Article
Medicine, General & Internal
Satoshi Okumura, Mikiya Ishihara, Naomi Kiyota, Kimikazu Yakushijin, Kohichi Takada, Shinichiro Kobayashi, Hiroaki Ikeda, Makoto Endo, Koji Kato, Shigehisa Kitano, Akihiko Matsumine, Yasuhiro Nagata, Shinichi Kageyama, Taizo Shiraishi, Tomomi Yamada, Keizo Horibe, Kazuto Takesako, Hiroshi Miwa, Takashi Watanabe, Yoshihiro Miyahara, Hiroshi Shiku
Summary: CAR-T cell therapy is a promising treatment for malignancies, but progress in solid tumor treatment has been slow. In this study, we developed a CAR-T cell product that recognizes HLA-A*02:01 and MAGE-A4 antigen and demonstrated its safety and tolerability through preclinical studies.
Article
Medicine, General & Internal
Jeroen H. A. Creemers, Inka Pawlitzky, Konstantina Grosios, Uzi Gileadi, Mark R. Middleton, Winald R. Gerritsen, Niven Mehra, Licia Rivoltini, Ian Walters, Carl G. Figdor, Petronella B. Ottevanger, I. Jolanda M. de Vries
Summary: This study aims to investigate the safety, tolerability, and immune-modulatory activity of PRECIOUS-01 in patients with advanced NY-ESO-1-expressing solid tumors. The study is a first-in-human, open-label phase I trial with dose escalation to determine the maximum tolerated dose and/or recommended phase II dose.
Article
Medicine, General & Internal
Ruyuan Li, Xingyu Liu, Chunyan Song, Wei Zhang, Jiahao Liu, Xiaofei Jiao, Yang Yu, Shaoqing Zeng, Jianhua Chi, Yingjun Zhao, Guanchen Ma, Yabing Huo, Ming Li, Zikun Peng, Guiling Li, Jie Jiang, Qing-Lei Gao
Summary: This is a multicenter, single-arm, open-label clinical trial aiming to evaluate the efficacy and safety of sintilimab and bevacizumab in patients with recurrent or persistent OCCC who have failed platinum-containing chemotherapy. The primary endpoint is the objective response rate, and secondary endpoints include progression-free survival, disease control rate, and overall survival.
Article
Oncology
Michelle A. Hsu, Stephanie M. Okamura, C. Daniel De Magalhaes Filho, Daniele M. Bergeron, Ahiram Rodriguez, Melissa West, Deepak Yadav, Roger Heim, Jerry J. Fong, Miguel Garcia-Guzman
Summary: Photoimmunotherapy induces immunogenic cell death in tumors and activates immune responses. Combination with PD-1 blockade enhances anticancer efficacy and reduces non-illuminated tumor growth. This study provides insights into the immune mechanisms of photoimmunotherapy and demonstrates its potential in combination with other immunotherapy approaches.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Geriatrics & Gerontology
Erik D. Hanson, Lauren C. Bates, Elizabeth P. Harrell, David B. Bartlett, Jordan T. Lee, Chad W. Wagoner, Mohamdod S. Alzer, Dean J. Amatuli, Brian C. Jensen, Allison M. Deal, Hyman B. Muss, Kirsten A. Nyrop, Claudio L. Battaglini
Summary: Exercise may attenuate immunosenescence and improve immune cell response in older breast cancer survivors, although deficits in certain cell types like MAIT and CD3(+) are observed at baseline. Acute exercise leads to mobilization of immune cells, with trends towards improvement in BCS post-exercise, suggesting potential benefits of exercise training in rescuing immune dysfunction associated with aging and cancer.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Medicine, General & Internal
Atsushi Kagimoto, Yasuhiro Tsutani, Takahiro Mimae, Yoshihiro Miyata, Norihiko Ikeda, Hiroyuki Ito, Yoshimasa Maniwa, Kenji Suzuki, Masahiro Tsuboi, Kenichi Yoshimura, Seiji Umemoto, Morihito Okada
Summary: The study aims to investigate the pathological response of preoperative nivolumab treatment for clinical stage I NSCLC patients and its effectiveness for high-risk patients. The trial plans to enroll 50 patients and started recruitment in April 2019.
Review
Pharmacology & Pharmacy
Christine Grimaldi, Alex Ibraghimov, Andrea Kiessling, Benno Rattel, Changhua Ji, Claudette L. Fuller, Frank R. Brennan, Franziska Regenass-Lechner, Jacintha Shenton, Karen D. Price, Marie-Soleil Piche, Meredith A. Steeves, Rodney Prell, Sherri Dudal, Sven Kronenberg, Wendy Freebern, Diann Blanset
Summary: Harnessing the immune system to kill tumors has revolutionized cancer treatment, but it can also lead to adverse events that pose safety risks. This article reviews the biology and mechanisms of immune-mediated adverse effects and discusses industry approaches for nonclinical safety risk assessments in immune-oncology.
DRUG DISCOVERY TODAY
(2023)
Article
Medicine, General & Internal
Qiong Zhou, Jie Dong, Qingqing Sun, Nannan Lu, Yueyin Pan, Xinghua Han
Summary: NLR is a suitable biomarker for predicting pCR and survival in breast cancer patients receiving NACT, as low NLR is associated with higher pCR rates and better survival outcomes.
Article
Oncology
Jonathan Rios-Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart, Linda Xu, Ravinder Tammali, Li Cheng, Qun Du, Kevin Schifferli, Ray Rothstein, Ching Ching Leow, Jenny Heidbrink-Thompson, Xiaofang Jin, Changshou Gao, Jay Friedman, Brandy Wilkinson, Melissa Damschroder, Andrew J. Pierce, Robert E. Hollingsworth, David A. Tice, Emil F. Michelotti
MOLECULAR CANCER THERAPEUTICS
(2015)
Article
Oncology
Jonathan Rios-Doria, Nicholas Durham, Leslie Wetzel, Raymond Rothstein, Jon Chesebrough, Nicholas Holoweckyj, Wei Zhao, Ching Ching Leow, Robert Hollingsworth
Article
Chemistry, Multidisciplinary
Ryan N. Gilbreth, Shabazz Novarra, Leslie Wetzel, Stelios Florinas, Horacio Cabral, Kazunori Kataoka, Jonathan Rios-Doria, Ronald J. Christie, Manuel Baca
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Oncology
Carl M. Hay, Erin Sult, Qihui Huang, Kathy Mulgrew, Stacy R. Fuhrmann, Kelly A. McGlinchey, Scott A. Hammond, Raymond Rothstein, Jonathan Rios-Doria, Edmund Poon, Nick Holoweckyj, Nicholas M. Durham, Ching Ching Leow, Gundo Diedrich, Melissa Damschroder, Ronald Herbst, Robert E. Hollingsworth, Kris F. Sachsenmeier
Article
Oncology
Joseph Dosch, Elizabeth Ziemke, Shanshan Wan, Kathryn Luker, Theodore Welling, Karin Hardiman, Eric Fearon, Suneetha Thomas, Matthew Flynn, Jonathan Rios-Doria, Robert Hollingsworth, Ronald Herbst, Elaine Hurt, Judith Sebolt-Leopold
Article
Biotechnology & Applied Microbiology
J. Rios-Doria, J. Melendez, A. N. Monteiro
BIOTECHNIC & HISTOCHEMISTRY
(2010)
Article
Oncology
Jonathan Rios-Doria, Aneliya Velkova, Virna Dapic, Jose M. Galan-Caridad, Vesna Dapic, Marcelo A. Carvalho, Johana Melendez, Alvaro N. A. Monteiro
CANCER BIOLOGY & THERAPY
(2009)
Article
Chemistry, Medicinal
Puneet Tyagi, Sergei Pechenov, Jonathan RiosDoria, Luke Masterson, Niall J. Dickinson, Philip Howard, Shenlan Mao, Jay Harper, Leslie Wetzel, Kwok Yo, J. Anand Subramony
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Oncology
Jonathan Rios-Doria, Margaret Favata, Kerri Lasky, Patricia Feldman, Yvonne Lo, Gengjie Yang, Christina Stevens, Xiaoming Wen, Sarita Sehra, Kamna Katiyar, Ke Liu, Richard Wynn, Jennifer J. Harris, Min Ye, Susan Spitz, Xiaozhao Wang, Chunhong He, Yun-Long Li, Wenqing Yao, Maryanne Covington, Peggy Scherle, Holly Koblish
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Holly K. Koblish, Liangxing Wu, Liang-Chuan S. Wang, Phillip C. C. Liu, Richard Wynn, Jonathan Rios-Doria, Susan Spitz, Hao Liu, Alla Volgina, Nina Zolotarjova, Kanishk Kapilashrami, Elham Behshad, Maryanne Covington, Yan-Ou Yang, Jingwei Li, Sharon Diamond, Maxim Soloviev, Kevin O'Hayer, Stephen Rubin, Chrysi Kanellopoulou, Gengjie Yang, Mark Rupar, Darlise DiMatteo, Luping Lin, Christina Stevens, Yue Zhang, Pramod Thekkat, Ryan Geschwindt, Cindy Marando, Swamy Yeleswaram, Jeff Jackson, Peggy Scherle, Reid Huber, Wenqing Yao, Gregory Hollis
Summary: This study describes the identification and characterization of a novel oral small-molecule PD-L1 inhibitor, INCB086550. It shows that INCB086550 can selectively and potently block PD-L1/PD-1 interaction, induce PD-L1 dimerization and internalization, and stimulate cytokine production in human immune cells. In animal models and preliminary clinical data, INCB086550 demonstrates tumor growth reduction and increased immune activation, supporting its potential as an alternative therapy to antibody-based treatments.
Article
Oncology
Jonathan Rios-Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough, Allison Marrero, Cui Chen, Patrick Strout, Kathy Mulgrew, Kelly McGlinchey, Ryan Fleming, Binyam Bezabeh, John Meekin, David Stewart, Maureen Kennedy, Philip Martin, Andrew Buchanan, Nazzareno Dimasi, Emil Michelotti, Robert Hollingsworth
Article
Oncology
J Rios-Doria, A Fay, A Velkova, ANA Monteiro
CANCER BIOLOGY & THERAPY
(2006)
Article
Pharmacology & Pharmacy
Jonathan Rios-Doria, Adam Carie, Tara Costich, Brian Burke, Habib Skaff, Riccardo Panicucci, Kevin Sill
JOURNAL OF DRUG DELIVERY
(2012)
Article
Pharmacology & Pharmacy
Adam Carie, Jonathan Rios-Doria, Tara Costich, Brian Burke, Richard Slama, Habib Skaff, Kevin Sill
JOURNAL OF DRUG DELIVERY
(2011)