Article
Respiratory System
Shaosen Chen, Kunlun Huang, Lin Zou, Lu Chen, Peicun Hu
Summary: This study found that the combined detection of SHOX2 and RASSF1A gene methylation with CEA level has a high diagnostic value for malignant pleural effusion.
BMC PULMONARY MEDICINE
(2023)
Article
Veterinary Sciences
Hsu Mon Hla, Vachira Hunprasit, Jedsada Siripoonsup, Anudep Rungsipipat, Araya Radtanakatikanon
Summary: This study aimed to investigate the common etiologies causing different pleural fluid types and evaluate the usefulness of lactate dehydrogenase (LDH) in differentiating the etiology in modified transudates in cats. The results showed that modified transudate was the most common fluid type, with neoplasia being the predominant etiology. Pleural fluid LDH can be a useful adjunctive marker for diagnosing the etiology of modified transudate pleural effusion in cats.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Medical Laboratory Technology
Wen Zhao, Xi-Shan Cao, Yu-Ling Han, Xu-Hui Wen, Wen-Qi Zheng, Zhi-De Hu
Summary: Pleural effusion is a common symptom of various disorders, and the current diagnostic tools have limitations. Cell-free nucleic acids in pleural fluid may serve as potential diagnostic markers, as they are non-invasive, cost-effective, and objective.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Oncology
Alex Dipper, Nick Maskell, Anna Bibby
Summary: Malignant pleural mesothelioma (MPM) presents diagnostic challenges, with ancillary diagnostic tests such as immunocytochemical markers, molecular techniques, diagnostic biomarkers, and imaging discussed in cases where histological samples are unavailable or inconclusive. While no single adjunctive test has the sensitivity and specificity to diagnose MPM in isolation, correlation of pleural fluid cytology with radiology and biomarkers can help make an MDT-consensus diagnosis when invasive tests are not feasible.
Article
Medicine, General & Internal
Jiupeng Zhou, Yuanli Yang, Yongfeng Zhang, Heng Liu, Quanli Dou
Summary: This study aimed to develop a convenient and effective method for differentiating tuberculous and malignant pleural effusion. The diagnostic performance of the age/ADA ratio and other indicators were evaluated, and it was found that age/ADA has higher diagnostic accuracy than ADA and is a promising diagnostic index for tuberculous and malignant pleural effusion.
Article
Respiratory System
Zhi Yan, Jian-Xun Wen, Hua Wang, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Li Yan, Zhi-De Hu, Wen-Qi Zheng
Summary: This study evaluated the diagnostic accuracy of pleural fluid lactate dehydrogenase (LDH) to adenosine deaminase (ADA) ratio for tuberculous pleural effusion (TPE). The results showed that the LDH/ADA ratio has moderate diagnostic accuracy for TPE, but it does not provide any additional diagnostic value beyond ADA.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, Research & Experimental
David Nunez-Jurado, Isabel Rodriguez-Martin, Juan Miguel Guerrero, Jose Diego Santotoribio
Summary: This study evaluated the accuracy of biomarkers in pleural fluid and proposed a new diagnostic strategy for pleural effusion in patients with high levels of ADA in pleural fluid. The pleural fluid LDH/ADA ratio was found to be a useful diagnostic tool for distinguishing parapneumonic effusion (PPE) from non-PPE, and a decision tree with an accuracy of 89.96% was created to differentiate the four forms of pleural effusion (PPE, tuberculosis, malignant, and miscellaneous).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Xuxiang Song, Lun Guo, Qipan Zhang, Weili Chen, Wei Fan, Chengna Lv, Pan Tang, Zhaoxing Dong, Xudeng Ye, Qunli Ding
Summary: IL-36 alpha and IL-36Ra may serve as novel biomarkers for diagnosing TPE and PPE, respectively. The multivariate models established significantly enhance the diagnostic efficacy of both TPE and PPE. Furthermore, IL-36Ra can function as an indicator for assessing the extent of pleural inflammation. Additionally, the interaction among IL-36 cytokines in PF may contribute to their expression modulation.
CLINICA CHIMICA ACTA
(2023)
Review
Medical Laboratory Technology
Xi-Shan Cao, Wen-Qi Zheng, Zhi-De Hu
Summary: Parapneumonic pleural effusion (PPE) is a common complication in patients with pneumonia. Current biomarkers lack adequate performance for diagnosing and stratifying PPE, highlighting the need for further research to identify and validate novel biomarkers and their combinations for PPE management.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Oncology
Xin Zhang, Feng-Shuang Yi, Huan-Zhong Shi
Summary: This study identified four routinely detected variables as predictors of survival in MPE patients and developed a new prognostic model to guide clinical management of this complication. Patients were stratified into three prognosis subgroups based on risk assessment, each with different median survival periods.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Joman Javadi, Andre Goergens, Hanna Vanky, Dhanu Gupta, Anders Hjerpe, Samir EL-Andaloussi, Daniel Hagey, Katalin Dobra
Summary: This study analyzed tumor heterogeneity and extracellular vesicle diversity in pleural effusion as potential diagnostic markers for malignant pleural mesothelioma. Specific proteins associated with different types of vesicles were identified, providing insights into potential diagnostic markers for MPM.
Article
Medicine, General & Internal
Gaohua Han, Jun Li, Xinbo Liu, Ruyue Guo
Summary: This study investigated the clinical value of SMRP, CA125, MMP-7, and MMP-9 in pleural exudative effusion. Levels of these markers were significantly higher in the malignant group compared to the benign group. The combined detection of SMRP, CA125, MMP-7, and MMP-9 showed higher efficacy in diagnosing malignant pleural effusion. There was a positive correlation between SMRP and CA125 as well as MMP-7, and a moderate positive correlation between MMP-7 and MMP-9.
Article
Oncology
Xi-Shan Cao, Wen Zhao, Xu-Hui Wen, Yu-Ling Han, Li Yan, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Wen-Qi Zheng, Zhi-De Hu
Summary: This study assessed the accuracy of pleural fluid homocysteine in discriminating between MPE and BPE, and found that its diagnostic accuracy was low.
Article
Multidisciplinary Sciences
Jyoti Jain, Pooja Jadhao, Shashank Banait, Preetam Salunkhe
Summary: The study found that GXpert assay has a very high specificity but low sensitivity in diagnosing TPE. For clinically and radiologically suspected patients, especially in high TB burden countries, a physician's clinical acumen along with routine pleural fluid analysis should be the key factor in diagnosing TPE.
Article
Infectious Diseases
Hansheng Wang, Lei Wang, Dan Yu, Guoshi Luo, Shuguo Yang, Yan Liu, Tao Ren, Meifang Wang
Summary: This study retrospectively analyzed the diagnosis and treatment course of 14 cases of exudative pleural effusion (EPE) caused by lung fluke infection and proposed a practical diagnosis approach. It was found that all patients had eosinophilia in peripheral blood and a history of special ingestion. Lung fluke infection should be highly suspected in patients with unexplained pleural effusion, especially when pleural fluid or pleural biopsy shows eosinophilic PE or eosinophils infiltration.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
