Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples

Antibody-free digital influenza virus counting based on neuraminidase activity

(2019) Kazuhito V. Tabata et al.   Scientific Reports

Accurate high-throughput screening based on digital protein synthesis in a massively parallel femtoliter droplet array

(2019) Yi Zhang et al.   Science Advances

Digital enzyme assay using attoliter droplet array

(2018) Takao Ono et al.   ANALYST

Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures

(2018) Jagannath Swaminathan et al.   NATURE BIOTECHNOLOGY

Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

(2016) Lucia De Monte et al.   CANCER RESEARCH

A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate

(2015) Yusuke Obayashi et al.   ANALYST

Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes

(2015) Toru KOMATSU et al.   ANALYTICAL SCIENCES

Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms

(2015) Kazufumi Honda et al.   Scientific Reports

Quinone-Methide Species, A Gateway to Functional Molecular Systems: From Self-Immolative Dendrimers to Long-Wavelength Fluorescent Dyes

(2014) Samer Gnaim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Detection of post-translational modifications in single peptides using electron tunnelling currents

(2014) Takahito Ohshiro et al.   Nature Nanotechnology

Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity

(2014) Rikiya Watanabe et al.   Nature Communications

Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe

(2013) Mitsuyasu Kawaguchi et al.   ACS Chemical Biology

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Altered Plasma Apolipoprotein Modifications in Patients with Pancreatic Cancer: Protein Characterization and Multi-Institutional Validation

(2012) Kazufumi Honda et al.   PLoS One

Development of a highly selective fluorescence probe for alkaline phosphatase

(2011) Mitsuyasu Kawaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region

(2011) Takahiro Egawa et al.   CHEMICAL COMMUNICATIONS

Specific increase in serum autotaxin activity in patients with pancreatic cancer

(2011) Yousuke Nakai et al.   CLINICAL BIOCHEMISTRY

Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor

(2011) Mitsuyasu Kawaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction

(2009) Karine Masse et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Two pathways for lysophosphatidic acid production

(2008) J AOKI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS