Article
Medicine, General & Internal
Houjin Dongye, Yizheng Tian, Dan Qi, Yanbo Du, Lei Yan
Summary: The influence of endometrioma on oocyte and embryo competence is inconclusive, and the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and explore whether surgery could improve oocyte and embryo competence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Xueqian Ma, Long Cui, Lin Chen, Jun Zhang, Xiaohui Zhang, Quanmin Kang, Fan Jin, Yinghui Ye
Summary: This study found that maternal plasma concentrations of perfluorooctanoic acid (PFOA) were negatively associated with the numbers of retrieved oocytes, mature oocytes, 2 PN zygotes, and good-quality embryos, while higher paternal plasma PFOA concentrations were significantly associated with reduced numbers of 2 PN zygotes. However, none of the maternal or paternal PFAS were significantly associated with the probability of implantation, clinical pregnancy, or live birth.
ENVIRONMENTAL POLLUTION
(2021)
Article
Agriculture, Dairy & Animal Science
Adel R. Moawad, Ali Salama, Magdy R. Badr, Mohamed Fathi
Summary: Supplementation of L-Carnitine (LC) during in vitro maturation (IVM) of canine oocytes improves maturation, fertilization, and preimplantation embryo development rates following IVF and in vitro culture (IVC).
Article
Endocrinology & Metabolism
Lixia Zhu, Qiyu Yang, Huizi Jin, Juepu Zhou, Meng Wang, Liu Yang, Zhou Li, Kun Qian, Lei Jin
Summary: This study identified different phenotypes in patients with oocyte maturation arrest (OMA), and found that clinical outcomes were associated with the presence of gene mutations and the classification of oocyte phenotypes. A triage system was proposed to optimize resource allocation and maximize patient benefit.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Edgardo Somigliana, Letizia Li Piani, Alessio Paffoni, Noemi Salmeri, Michele Orsi, Laura Benaglia, Paolo Vercellini, Paola Vigano'
Summary: Apart from the negative effect of surgical excision of endometriomas on ovarian reserve, endometriosis does not significantly affect IVF outcomes. Ovarian response, oocyte quality, and embryonic development remain largely unaffected.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Lanlan Liu, Xiaoming Jiang, Zhenfang Liu, Jinghua Chen, Chao Yang, Kaijie Chen, Xiaolian Yang, Jiali Cai, Jianzhi Ren
Summary: This study aimed to investigate the relationship between oocyte degeneration and sibling embryo development potential and clinical outcomes in conventional IVF cycles. The presence of oocyte degeneration was found to have adverse effects on embryo development and clinical outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Irene Dimitriadis, Nikica Zaninovic, Alejandro Chavez Badiola, Charles L. Bormann
Summary: Traditional morphological assessment of embryos can lead to variability in IVF success rates. To improve success rates, multiple embryos are often transferred, resulting in high-risk multiple pregnancies. Artificial intelligence is increasingly being used in the embryology laboratory to enhance IVF outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Isotta M. Magaton, Anja Helmer, Markus Eisenhut, Marie Roumet, Petra Stute, Michael von Wolff
Summary: High-dose gonadotrophin stimulation affects oocyte and early-stage embryo development. The study found that natural cycle IVF (NC-IVF) had higher rates of mature oocytes and fertilized zygotes compared to conventional IVF (cIVF). In addition, the morphology of the cleavage-stage embryo was also improved in NC-IVF.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Veterinary Sciences
Ahmed Ezzat Ahmed, Ramya Ahmad Sindi, Nasra Ahmed Yousef, Hassan A. Hussein, Magdy R. Badr, Khalid M. Al Syaad, Fatimah A. Al-Saeed, Ahmed Saad A. Hassaneen, Mohamed Abdelrahman, Montaser Elsayed Ali
Summary: The study investigated the effects of adding epidermal growth factors (EGF) and/or b-Mercaptoethanol (bME) to the buffalo in vitro embryo production process. Results showed that supplementing EGF (20 ng/mL) to the TCM-199, IVF-TALP, or SOF media improved the growth and development of buffalo embryos. EGF (50 ng/mL) stimulated embryo production when added to the IVF-TALP or SOF media, but not the IVM medium. bME was less efficient, but could enhance embryo growth when added to the IVF-TALP media at a 50 mu M concentration.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Obstetrics & Gynecology
Pietro Bortoletto, Phillip A. Romanski, Brady I. Magaoay, Zev Rosenwaks, Steven D. Spandorfer
Summary: The timing from oocyte retrieval to frozen embryo transfer in the natural cycle did not significantly impact live birth rate or neonatal outcomes, with preimplantation genetic testing (PGT) being the only factor associated with increased odds of live birth.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Zhiqin Bu, Jiaxin Zhang, Yile Zhang, Yingpu Sun
Summary: The study found that oocyte donation does not compromise CLBR and can reduce embryo wastage. Additionally, in patients with 10 retrieved oocytes, CLBR remained good at 73%. Therefore, it is possible to expand oocyte donors by decreasing the number of oocytes kept for own use from 15 to 10 after adequate communication with patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Peter Mauchart, Reka Anna Vass, Bernadett Nagy, Endre Sulyok, Jozsef Bodis, Kalman Kovacs
Summary: Based on current findings, this review provides a comprehensive overview of the impact of oxidative stress on the quality of gametes and embryos during assisted reproductive techniques (ART). It discusses the origins of reactive oxygen species (ROS), mechanisms of oxidative stress-induced damage, and the underestimated hazard of light exposure-related photo-oxidation. The review also emphasizes the role and significance of antioxidants and light protection in the development of gametes and embryos in vivo and in vitro.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Environmental Sciences
Baek Kiook, Park Jong-Tae, Kwak Kyeongmin
Summary: The study found that urinary bisphenol S (BPS) played an important role in the diagnosis of asthma in Korean adolescent females. Compared to patients diagnosed with asthma after 60 months, high urinary BPS significantly increased the odds of lifetime asthma prevalence.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Endocrinology & Metabolism
Shintaro Kamijo, Toshio Hamatani, Hiroyuki Sasaki, Hiroki Suzuki, Akane Abe, Osamu Inoue, Maki Iwai, Seiji Ogawa, Kei Odawara, Kanako Tanaka, Mutsumi Mikashima, Masami Suzuki, Kenji Miyado, Ryo Matoba, Yasushi Odawara, Mamoru Tanaka
Summary: By analyzing miRNAs in embryo culture medium, we generated a predictive model for embryo implantation success and identified a non-invasive evaluation method. The abundance levels of certain miRNAs in the culture medium were found to be associated with the quality of blastocysts and implantation success.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Perrine Capmas, Jean-Luc Brun, Guillaume Legendre, Martin Koskas, Philippe Merviel, Herve Fernandez
Summary: This study evaluated the effect of UPA on abnormal uterine bleeding due to adenomyosis, showing a significantly higher rate of women with PBAC score under 75 in the UPA group compared to the placebo group after 28 days of treatment, along with a significant reduction in pain for the UPA group. At 6 months, there was no significant difference in outcomes between the two groups, indicating that UPA could be a potential option for treating this condition.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Claire de Moreuil, Jacob Hannigsberg, Juliette Chauvet, Annabelle Remoue, Christophe Tremouilhac, Philippe Merviel, Charles Bellot, Brigitte Pan Petesch, Emmanuelle Le Moigne, Karine Lacut, Pascale Marcorelles
Summary: Placental abruption cases with stillbirth or neonatal death accounted for 24.4%, with a higher prevalence of pre-eclampsia and intrauterine growth restriction. Cases were associated with more autoimmune diseases, less pre-eclampsia, and more preterm deliveries compared to controls.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2021)
Article
Environmental Sciences
Julien Caudeville, Corentin Regrain, Frederic Tognet, Roseline Bonnard, Mohammed Guedda, Celine Brochot, Maxime Beauchamp, Laurent Letinois, Laure Malherbe, Fabrice Marliere, Francois Lestremau, Karen Chardon, Veronique Bach, Florence Anna Zeman
Summary: This paper presents the methodological framework developed by INERIS for assessing human exposure, based on environmental pollution data and spatial analysis methods. This integrated approach helps to identify overexposed populations and provides data for evaluating the relationship between health and the environment.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Karen Chardon, Veronique Bach, Celine Brochot, Roseline Bonnard, Frederic Tognet, Laure Malherbe, Laurent Letinois, Emmanuelle Boulvert, Fabrice Marliere, Francois Lestremau, Julien Caudeville
Summary: This study used an integrated exposure assessment approach to evaluate the exposure of pregnant women to chlorpyrifos in Picardy at a regional scale, finding that ingestion route was the main contributor to chlorpyrifos exposure. The study demonstrated the feasibility of comparing modeled predictions with biomonitoring data.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
P. Merviel, S. Bouee, A. S. Jacamon, J. J. Chabaud, M. T. Le Martelot, S. Roche, C. Rince, H. Drapier, A. Perrin, D. Beauvillard
Summary: The study found that blastocyst transfers were associated with higher clinical pregnancy and birth rates than cleaved embryo transfers in the general population but not in a selected population. Serum progesterone levels on the eve of the trigger day and on the day itself were predictive of the likelihood of pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biology
Thi Cuc Mai, Anne Braun, Veronique Bach, Amandine Pelletier, Rene de Seze
Summary: Recent studies have shown that rodents exposed to low-intensity radiofrequency (RF) exhibit vasoconstriction responses similar to those in cold conditions, suggesting that RF exposure triggers physiological events associated with responses to cold in rats. RF exposure also leads to increased plasma concentrations of noradrenaline and fatty acids, similar to the response to cold stimuli.
BIOELECTROMAGNETICS
(2021)
Review
Public, Environmental & Occupational Health
G. Chene, E. Cerruto, P. Merviel, A. Agostini, P. Crochet, G. Giraudet, P. Capmas, H. Fernandez, O. Graesslin
Summary: The study evaluated different techniques for Essure(R) microinserts removal and assessed the risk of device fracture and intra- and post-operative complications. The most frequent surgical techniques were laparoscopic salpingectomy (LS), laparoscopic cornuectomy (LC), and laparoscopic or vaginal hysterectomy (LH, VH) with en-bloc salpingectomy. Complications were more severe and frequent with hysterectomy compared to the LC and LS procedures.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2021)
Article
Multidisciplinary Sciences
Marion Guibourdenche, Hiba El Khayat El Sabbouri, Narimane Djekkoun, Hafida Khorsi-Cauet, Veronique Bach, Pauline M. Anton, Jerome Gay-Queheillard
Summary: Maternal exposure to pesticide or a high fat diet may have preliminary impacts on offspring's gut barrier function, but co-exposure to both factors did not exacerbate the effects observed with each factor separately.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Philippe Merviel, Pandora James, Marianne Carlier, Isabelle Thomas-Kergastel, Marine Guilloique, Virginie Conan-Charlet, Clara Bastard, Pascale Marcorelles, Yannick Jobic, Pierre-Francois Dupre
Summary: Xanthogranulomatous endometritis is a rare benign condition that can mimic endometrial carcinoma.
CLINICAL CASE REPORTS
(2021)
Article
Medicine, General & Internal
Pierre-Francois Dupre, Delphine Legoupil, Camille Vigouroux, Virginie Conan-Charlet, Isabelle Kergastel, Philippe Merviel, Nathalie Kerfant
Summary: Primary melanoma in the vagina is rare, and this report describes a case of laparoscopy-assisted immediate vaginal reconstruction using a vertical pedicled deep inferior epigastric perforator flap.
CLINICAL CASE REPORTS
(2021)
Review
Obstetrics & Gynecology
Philippe Merviel, Marion Labarre, Pandora James, Sarah Bouee, Jean-Jacques Chabaud, Sylvie Roche, Rosalie Cabry, Florence Scheffler, Emmanuelle Lourdel, Moncef Benkhalifa, Henri Copin, Hortense Drapier, Damien Beauvillard
Summary: This study compares the clinical pregnancy rate in cases of unexplained infertility with intrauterine insemination (IUI) and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The results show that IVF/ICSI has higher pregnancy rates, especially in women with secondary unexplained infertility, in the first two cycles, and in women receiving a transfer of two embryos. The study recommends IVF/ICSI treatment for unexplained infertility.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Karine Morcel, Philippe Merviel, Diane Pertuisel, Pandora James, Sarah Bouee, Mathilde Le Guillou, Jean-Jacques Chabaud, Sylvie Roche, Hortense Drapier, Aurore Perrin, Damien Beauvillard
Summary: This retrospective study evaluated the clinical pregnancy and live birth rates in women under 38 years old with AMH level < 1.2 ng/ml in their first IVF+/-ICSI cycle. The results showed that the level of AMH did not affect the number of embryos transferred, the clinical pregnancy, and the live birth rates in this population.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Philippe Merviel, Christie Rebahi, Pandora James, Isabelle Kergastel, Fanny Bourhis-Guizien, Virginie Conan-Charlet, Fanny Derquin, Anne-Claire Hardy-Bessard, Pierre-Francois Dupre, Karine Morcel
Summary: There are fewer than ten cases of deep endometriosis degeneration documented in the literature. Prolonged duration of endometriosis, ovarian stimulation, perimenopause, and obesity are factors that can increase the risk of endometriosis degeneration.
CLINICAL CASE REPORTS
(2023)
Article
Developmental Biology
Marion Guibourdenche, Hiba El Khayat El Sabbouri, Fideline Bonnet, Narimane Djekkoun, Hafida Khorsi-Cauet, Aurelie Corona, Jean Guibourdenche, Veronique Bach, Pauline M. Anton, Jerome Gay-Queheillard
Summary: Maternal exposure to chlorpyrifos or a high-fat diet may lead to changes in offspring's liver metabolic activity, even without direct exposure to harmful factors. Exposure to HFD alone or to CPF alone gives similar results in offspring, changes in the same direction.
CELLS & DEVELOPMENT
(2021)
Article
Medicine, General & Internal
Philippe Merviel, Caroline Lelievre, Tatiana Cambier, Isabelle Thomas-Kergastel, Pierre-Francois Dupre
Summary: ACUM is a rare and underdiagnosed pathology, usually treated with radical surgery which can result in uterine scarring. Ethanol sclerotherapy, mimicking the treatment of recurrent endometrioma, offers a solution that avoids uterine scarring and potential risks, enabling rapid pregnancy achievement.
CLINICAL CASE REPORTS
(2021)
