Article
Neurosciences
Hui Wang, Jianxia Xu, Miao Yu, Gaiyan Zhou, Jingru Ren, Yajie Wang, Huifen Zheng, Yu Sun, Jun Wu, Weiguo Liu
Summary: This study aimed to explore the potential clinical utility of functional and structural magnetic resonance imaging (MRI) in the diagnosis of depression in Parkinson's disease (DPD). The results showed that both the ReHo value of the left dorsolateral superior frontal gyrus and the DC value of the left inferior temporal gyrus were equally well suited for the diagnosis and differential diagnosis of DPD, with a combination of them being slightly preferable. The multimodal MRI technique represents a promising approach for the classification of subjects with PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Lu Chen, Ting Huang, Di Ma, Yu-Chen Chen
Summary: This study used resting-state functional magnetic resonance imaging (fMRI) to investigate the intrinsic functional connectivity (FC) pattern of the default mode network (DMN) in patients with Parkinson's disease (PD). The results showed increased FC between the posterior cingulate cortex (PCC) and other brain regions in PD patients compared to healthy controls (HCs). The increased FC values in the right precuneus were also positively correlated with motor severity in the PD group. These findings suggest that altered connectivity in the DMN may play a crucial role in the cognitive decline observed in PD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yi-Hui Qiu, Zhi-Heng Huang, Yu-Yuan Gao, Shu-Jun Feng, Biao Huang, Wan-Yi Wang, Qi-Huan Xu, Jie-Hao Zhao, Yu-Hu Zhang, Li-Min Wang, Kun Nie, Li-Juan Wang
Summary: The aim of this research was to investigate alterations in functional brain networks in Parkinson's disease patients with depression (DPD). The study found that DPD patients had decreased local efficiency in certain brain regions compared to healthy controls, and showed weaker connections between different brain regions compared to the control group. These results suggest that PD depression is associated with disruptions in the topological organization of functional brain networks.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Weiwei Fu, Cimin Dai, Jie Chen, Letong Wang, Tao Song, Ziyi Peng, Mengmeng Xu, Lin Xu, Yuguo Tang, Yongcong Shao
Summary: This study used resting-state functional magnetic resonance imaging to investigate the effects of 36 hours of total sleep deprivation on vigilant attention and resting-state network. The results showed that sleep deprivation impaired vigilant attention and caused changes in functional connectivity, which were positively correlated with reaction time to psychomotor vigilance tasks. These findings suggest that sleep deprivation impacts visual attention and the reception of information in the brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Song'an Shang, Siying Zhu, Jingtao Wu, Yao Xu, Lanlan Chen, Weiqiang Dou, Xindao Yin, Yu-Chen Chen, Dejuan Shen, Jing Ye
Summary: This study found disrupted topology of high-order functional connectivity networks in patients with Parkinson's disease prior to clinical symptoms of cognitive impairment. There were extensive alterations in topological properties and improved differentiation ability. These findings provide complementary insights into the complex neurodegeneration in Parkinson's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Psychiatry
Zilin Zhou, Bin Li, Jiaxin Jiang, Hailong Li, Lingxiao Cao, Suming Zhang, Yingxue Gao, Lianqing Zhang, Changjian Qiu, Xiaoqi Huang, Qiyong Gong
Summary: This study investigated altered intrinsic connectivity in the insula of OCD patients, revealing increased connectivity between the insula and precuneus gyrus in OCD patients compared to healthy controls, as well as decreased connectivity between the insula and bilateral lingual gyrus. The reduced connectivity was negatively correlated with the severity of depression symptoms in the OCD group, suggesting a potential role of the insula in depressive symptoms in OCD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Liang, Ling-Ling Wang, Xiao-Dong Jiang, Dong-Jian Chen, Tian-An Huang, Wen-Bin Ding
Summary: This study investigated changes in hippocampal structure and resting-state functional connectivity (FC) in patients with depression in Parkinson disease (DPD). The results showed that the volume of bilateral hippocampi in patients with DPD was significantly decreased and negatively correlated with the severity of depressive disorder. The weakened FC of the right hippocampus to the right occipital lobe and the left precuneus may play an important role in the neurological basis of DPD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Linghong Kong, Haijun Li, Yongqiang Shu, Xiang Liu, Panmei Li, Kunyao Li, Wei Xie, Yaping Zeng, Dechang Peng
Summary: The study explored the functional connectivity between insular subregions and other brain areas in patients with obstructive sleep apnea (OSA) and its relationship with clinical symptoms. The results showed that OSA patients exhibited abnormal functional connectivity in the insular subregions, which were related to cognitive, emotional, and sensorimotor networks. These findings provide a new imaging perspective for understanding OSA-related cognitive and affective disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuming Zhang, Fenrong Chen, Jiayu Wu, Chengxiang Liu, Guang Yang, Ruiqing Piao, Bowen Geng, Ke Xu, Peng Liu
Summary: The study revealed that Crohn's disease patients exhibited decreased gray matter volume in the insula compared to healthy controls, along with differences in structural covariance and functional connectivity. After controlling for psychological factors, some differences were not significant. The functional connectivity between the insula and other brain regions was negatively correlated with the CD activity index.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Neurosciences
Thushini Manuweera, Mallory A. Kisner, Erika Almira, Reza Momenan
Summary: This study aimed to investigate the differences in the anterior and posterior insula in individuals with alcohol use disorder. The results indicated structural differences mainly in the anterior regions, while functional connectivity differences were observed in both the anterior and posterior insula. These differences in connectivity were observed with various brain regions involved in higher cognitive and emotional tasks.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Clinical Neurology
Wen Su, Kai Li, Chun-Mei Li, Xin-Xin Ma, Hong Zhao, Min Chen, Shu-Hua Li, Rui Wang, Bao-Hui Lou, Hai-Bo Chen, Chuan-Zhu Yan
Summary: The study found that Parkinson's disease patients with left onset had lower functional connectivity between the left orbitofrontal cortex and the left dorsal rostral putamen compared to those with right onset. Additionally, patients with left onset showed abnormal functional connectivity in the right hemisphere. The findings suggest that lateralization of motor symptoms is associated with distinct characteristics of cortico-striatal circuits in Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Andrea Ciorba, Stavros Hatzopoulos, Cristina Cogliandolo, Chiara Bianchini, Martina Renna, Luca Perrucci, Magdalena Skarzynska, Piotr Henryk Skarzynski, Paolo Campioni, Corrado Cittanti, Aldo Carnevale, Melchiore Giganti, Stefano Pelucchi
Summary: The study utilized fMRI to evaluate brain maps generated from healthy individuals' response to olfactory stimuli, revealing that the left anterior insula is primarily activated by odorous stimuli and other cortical areas are also involved.
Article
Neuroimaging
Jinsol Kim, Eun Namgung, Suji Lee, Eunji Ha, Haejin Hong, Yumi Song, Hyangwon Lee, Sohyun Oh, In Kyoon Lyoo, Sujung Yoon, Hyeonseok Jeong
Summary: This study aimed to investigate the characteristics of insular functional connectivity in patients with complex regional pain syndrome (CRPS) and its association with clinical characteristics. The results showed that CRPS patients had lower functional connectivity in the insula compared to healthy controls. This study suggests the pivotal roles of the insula in dysfunctional pain processing of CRPS patients.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Qinru Liu, Zhenni Mao, Changlian Tan, Sainan Cai, Qin Shen, Min Wang, Junli Li, Lin Zhang, Fan Zhou, Chendie Song, Jiaying Yuan, Yujing Liu, Jun Liu, Haiyan Liao
Summary: This study aims to investigate the neural network mechanism of Parkinson's disease with different degrees of depression. The results showed that there are abnormal functional connectivity in multiple brain networks among different groups. The degree of decreased functional connectivity in the interior Salience Network is related to the severity of depression, which can be used as an imaging marker for judging the severity of depression.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Wan Liu, Yang Shen, Yuan Zhong, Yu Sun, Jiaying Yang, Wenbin Zhang, Lei Yan, Weiguo Liu, Miao Yu
Summary: This study examined the mechanism of levodopa in Parkinson's disease patients and found that levodopa improves symptoms by decreasing the functional connectivity between the subregions of the thalamus and the cortex. These findings provide a basis for further exploration of the functional activity of thalamic subregions and offer new insights into precision treatment in Parkinson's disease patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)